Skip to main content

Research Repository

Advanced Search

All Outputs (53)

Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study (2021)
Journal Article
Kirby, L., Gran, S., Orekoya, F., Owen, C., & Simpson, R. (2021). Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study. British Journal of Dermatology, 185(5), 1063-1065. https://doi.org/10.1111/bjd.20583

Increasing evidence suggests the pathogenesis of male genital lichen sclerosus (LS) is driven by chronic, occluded exposure of susceptible epithelium to the irritant effect of urine (1, 2). It is not clear how this can be extrapolated to females, how... Read More about Is urinary incontinence associated with vulval lichen sclerosus in females? A cross‐sectional study.

Do patient characteristics matter when calculating sample size for eczema clinical trials? (2021)
Journal Article
Howells, L., Gran, S., Chalmers, J. R., Stuart, B., Santer, M., Bradshaw, L., Gaunt, D. M., Ridd, M. J., Gerbens, L. A. A., Spuls, P. I., Huang, C., Francis, N. A., & Thomas, K. S. (2021). Do patient characteristics matter when calculating sample size for eczema clinical trials?. Skin Health and Disease, 1(3), Article e42. https://doi.org/10.1002/ski2.42

Background: The Patient-Oriented Eczema Measure (POEM) is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To ensure that the statistical significance of clinical trial results is meani... Read More about Do patient characteristics matter when calculating sample size for eczema clinical trials?.

Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis (2021)
Journal Article
Cunliffe, A., Gran, S., Ali, U., Grindlay, D., Lax, S., Williams, H., & Burden-Teh, E. (2021). Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis. Skin Health and Disease, 1(2), Article e29. https://doi.org/10.1002/ski2.29

Importance: Previous studies report both co-existence and mutual exclusivity of atopic eczema (AE) and psoriasis, but these have not been appraised systematically. Knowledge of such disease association throws light on disease mechanisms and may influ... Read More about Can atopic eczema and psoriasis coexist? A systematic review and meta‐analysis.

Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records (2021)
Journal Article
Taqi, A., Gran, S., & Knaggs, R. D. (2021). Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records. Osteoarthritis and Cartilage, 3(2), Article 100165. https://doi.org/10.1016/j.ocarto.2021.100165

Objective

To examine the association between the current use of analgesics and the risk of falls in people with knee osteoarthritis (KOA).

Methods

A retrospective cohort study using data from the UK Clinical Practice Research Datalink, with... Read More about Current Use of Analgesics and the Risk of Falls in people with Knee Osteoarthritis: A Population-based Cohort Study Using Primary Care and Hospital Records.

Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis (2021)
Journal Article
Kirby, L., Gran, S., Kreuser-Genis, I., Owen, C., & Simpson, R. (2021). Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis. Skin Health and Disease, 1(1), Article e13. https://doi.org/10.1002/ski2.13

Background
Lichen sclerosus (LS) is a scarring chronic inflammatory disease with a predilection for genital skin in both sexes. The aetiology of LS is controversial, but evidence increasingly suggests that the occluded exposure of susceptible epith... Read More about Is urinary incontinence associated with lichen sclerosus in females? A systematic review and meta‐analysis.

Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England (2021)
Journal Article
Persson, M., Harman, K., Thomas, K., Chalmers, J., Vinogradova, Y., Langan, S., Hippisley-Cox, J., & Gran, S. (2021). Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England. BMC Medical Research Methodology, 21(1), Article 22. https://doi.org/10.1186/s12874-021-01212-1

Background
Trials of novel agents are required to improve the care of patients with rare diseases, but trial feasibility may be uncertain due to concerns over insufficient patient numbers. We aimed to determine the size of the pool of potential part... Read More about Using electronic health records to inform trial feasibility in a rare autoimmune blistering skin disease in England.

Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England (2020)
Journal Article
Persson, M. S., Harman, K. E., Vinogradova, Y., Langan, S. M., Hippisley-Cox, J., Thomas, K. S., & Gran, S. (2020). Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England. BMJ Open, 10(7), e035934. https://doi.org/10.1136/bmjopen-2019-035934

Objectives: The validity of bullous pemphigoid and pemphigus vulgaris recording in routinely collected healthcare data in the UK is unknown. We assessed the positive predictive value (PPV) for bullous pemphigoid and pemphigus vulgaris primary care Re... Read More about Validation study of bullous pemphigoid and pemphigus vulgaris recording in routinely collected electronic primary healthcare records in England.

A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans (2020)
Journal Article
Durack, A., Gran, S., Gardiner, M., Jain, A., Craythorne, E., Proby, C., Marsden, J., Harwood, C., & Matin, R. (2021). A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans. British Journal of Dermatology, 184(4), 731-739. https://doi.org/10.1111/bjd.19346

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin cancer. Standard treatment in the United Kingdom (UK) is either surgical wide local excision (WLE) or Mohs micrographic surgery (MMS). It is unclear which approach has the lower recurr... Read More about A 10‐year Review of Surgical Management of Dermatofibrosarcoma Protuberans.

Incidence, prevalence and mortality of bullous pemphigoid in England 1998–2017: a population-based cohort study* (2020)
Journal Article
Persson, M. S., Harman, K. E., Vinogradova, Y., Langan, S. M., Thomas, K. S., Hippisley-Cox, J., & Gran, S. (2021). Incidence, prevalence and mortality of bullous pemphigoid in England 1998–2017: a population-based cohort study*. British Journal of Dermatology, 184(1), 68-77. https://doi.org/10.1111/bjd.19022

Background: A rising incidence and high mortality were found for bullous pemphigoid (BP) over a decade ago in the UK. Updated estimates of its epidemiology are required to understand the healthcare needs of an ageing population. Objectives: To determ... Read More about Incidence, prevalence and mortality of bullous pemphigoid in England 1998–2017: a population-based cohort study*.

Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP) (2019)
Journal Article
Howells, L. M., Chalmers, J. R., Gran, S., Ahmed, A., Apfelbacher, C., Burton, T., Howie, L., Lawton, S., Ridd, M. J., Rogers, N. K., Sears, A. V., Spuls, P., von Kobyletzki, L., & Thomas, K. S. (2020). Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP). British Journal of Dermatology, 183(3), 524-536. https://doi.org/10.1111/bjd.18780

Background: Eczema control has been identified as an important outcome by key stakeholders in eczema research (including patients, carers, healthcare professionals and researchers) but no validated instruments for the domain have been identified. Obj... Read More about Development and initial testing of a new instrument to measure the experience of eczema control in adults and children: Recap of atopic eczema (RECAP).

Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics (2019)
Journal Article
Burden-Teh, E., Murphy, R., Gran, S., Nijsten, T., Hughes, C., & Thomas, K. S. (2019). Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics. BMJ Open, 9(8), e028689. https://doi.org/10.1136/bmjopen-2018-028689

Introduction Diagnosing psoriasis in children can be challenging. Early and accurate diagnosis is important to ensure patients receive psoriasis specific treatment and monitoring. It is recognised that the physical, psychological, quality of life, fi... Read More about Protocol for a case-control diagnostic accuracy study to develop diagnostic criteria for psoriasis in children (DIPSOC study): a multicentre study recruiting in UK paediatric dermatology clinics.

The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm (2019)
Journal Article
Fletcher-Smith, J. C., Pandyan, A. D., Fletcher-Smith, J. C., Walker, D. M., Allatt, K., Sprigg, N., James, M., Ratib, S., Boadu, J., Richardson, C., & Pandyan, A. D. (2019). The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm. Clinical Rehabilitation, 33(12), 1919-1930. https://doi.org/10.1177/0269215519868834

© The Author(s) 2019. Objective: To establish feasibility of initiating electrical stimulation treatment of wrist extensors and flexors in patients early after stroke to prevent muscle contractures and pain. Design: Feasibility randomized controlled... Read More about The ESCAPS study: a feasibility randomized controlled trial of early electrical stimulation to the wrist extensors and flexors to prevent post-stroke complications of pain and contractures in the paretic arm.

Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016 (2019)
Journal Article
van Lee, C. B., Kan, W. C., Gran, S., Mooyaart, A., Mureau, M. A., Williams, H., Matin, R., van den Bos, R., & Hollestein, L. M. (2019). Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016. Acta Dermato-Venereologica, 99(12), 1160-1165. https://doi.org/10.2340/00015555-3287

Dermatofibrosarcoma protuberans is a rare soft tissue tumour with a very low (less than 0.5%) rate of metastasis. Rates of re-excision and recurrence were determined using data from the Netherlands Cancer Registry between 1989 and 2016. Of the 1,890... Read More about Dermatofibrosarcoma Protuberans Re-excision and Recurrence Rates in the Netherlands Between 1989 and 2016.

Development of clinical diagnostic criteria for plaque psoriasis in children: an eDelphi consensus study with the International Psoriasis Council (2019)
Journal Article
Burden‐Teh, E., Thomas, K. S., Gran, S., & Murphy, R. (2019). Development of clinical diagnostic criteria for plaque psoriasis in children: an eDelphi consensus study with the International Psoriasis Council. British Journal of Dermatology, 181(4), 856-857. https://doi.org/10.1111/bjd.17994

Psoriasis in children can be a challenging diagnosis: the clinical presentation is often more subtle, may occur in covered sites and can be an unexpected diagnosis as psoriasis if often thought to occur at older ages. Poor recognition and delayed dia... Read More about Development of clinical diagnostic criteria for plaque psoriasis in children: an eDelphi consensus study with the International Psoriasis Council.

Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts (2019)
Journal Article
Andersen, Y. M., Egeberg, A., Ban, L., Gran, S., Williams, H. C., Francis, N. A., Knop, F. K., Gislason, G. H., Skov, L., & Thyssen, J. P. (2019). Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts. Diabetes Care, 42(6), 1095-1103. https://doi.org/10.2337/dc18-2158

Background
Topical corticosteroids (CS) are commonly used to treat inflammatory skin conditions including eczema and psoriasis. While topical CS package inserts describe hyperglycaemia and glycosuria as adverse drug reactions, it is unclear whether... Read More about Association between topical corticosteroid use and type 2 diabetes in two European population-based adult cohorts.

Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema (2019)
Journal Article
Howells, L., Thomas, K. S., Sears, A. V., Nasr, I., Wollenberg, A., Schuttelaar, M. L., Romeijn, G. L., Paller, A. S., Mueller, K., Doytcheva, K., Kataoka, Y., Daguze, J., Barbarot, S., Von Kobyletzki, L. B., Beckman, L., Ratib, S., Cowdell, F., Santer, M., & Chalmers, J. R. (2019). Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema. Journal of the European Academy of Dermatology and Venereology, 33(6), 1124-1132. https://doi.org/10.1111/jdv.15475

Background: Atopic eczema (also known as eczema) is a chronic, inflammatory skin condition that often afflicts patients’ health and wellbeing. The Harmonising Outcome Measures for Eczema (HOME) initiative recommends that “long-term control of eczema”... Read More about Defining and measuring " eczema control " : an international qualitative study to explore the views of those living with and treating atopic eczema.

Long-term topical corticosteroid use and risk of skin cancer: a systematic review (2018)
Journal Article
Ratib, S., Burden-Teh, E., Leonardi-Bee, J., Harwood, C., & Bath-Hextall, F. (in press). Long-term topical corticosteroid use and risk of skin cancer: a systematic review. JBI Database of Systematic Reviews and Implementation Reports, 16(6), https://doi.org/10.11124/jbisrir-2017-003393

Objective: The objective of this systematic review was to synthesize available research evidence to determine the risk of skin cancer in patients with long-term use of topical corticosteroids (TCS).
Introduction: Topical corticosteroids are one of... Read More about Long-term topical corticosteroid use and risk of skin cancer: a systematic review.

Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis (2018)
Journal Article
Ban, L., Labbouz, S., Grindlay, D. J., Batchelor, J. M., & Ratib, S. (2018). Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis. British Journal of Dermatology, 179(4), 971-972. https://doi.org/10.1111/bjd.16703

Vitiligo is a chronic disorder causing skin depigmentation with around 1% global prevalence, affecting people of all ages, skin types and genders.1 Due to the absence of melanin in lesional skin there is a theoretical concern that there might be a hi... Read More about Risk of skin cancer in people with vitiligo: a systematic review and meta-analysis.

How should minimally important change (MIC) scores for the Patient Oriented Eczema Measure (POEM) be interpreted?: a validation using varied methods (2018)
Journal Article
Howells, L., Ratib, S., Chalmers, J., Bradshaw, L., & Thomas, K. (2018). How should minimally important change (MIC) scores for the Patient Oriented Eczema Measure (POEM) be interpreted?: a validation using varied methods. British Journal of Dermatology, 178(5), https://doi.org/10.1111/bjd.16367

Background

The Patient Oriented Eczema Measure (POEM), scored 0-28, is the core outcome instrument recommended for measuring patient-reported atopic eczema symptoms in clinical trials. To date, two published studies have broadly concurred that the... Read More about How should minimally important change (MIC) scores for the Patient Oriented Eczema Measure (POEM) be interpreted?: a validation using varied methods.