All Outputs (11)

Tracking subjects' strategies in behavioural choice experiments at trial resolution. (2024)
Journal Article

Investigating how, when, and what subjects learn during decision-making tasks requires tracking their choice strategies on a trial-by-trial basis. Here we present a simple but effective probabilistic approach to tracking choice strategies at trial re... Read More about Tracking subjects' strategies in behavioural choice experiments at trial resolution..

Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro-behavioral mechanisms of reversal learning (2023)
Journal Article

In this issue, Griesius et al report that heterozygous Dlg2+/- rats showed a reversal learning impairment on a specific bowl-digging task, whereas other reversal tasks were unaffected. The study suggests that Dlg2 gene disruption, which has been link... Read More about Impaired reversal learning in the Dlg2+/− rat model of genetic risk for psychiatric disorder: Important questions regarding the neuro-behavioral mechanisms of reversal learning.

Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice (2022)
Journal Article

Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain... Read More about Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice.

Activity Subspaces in Medial Prefrontal Cortex Distinguish States of the World (2022)
Journal Article

Medial prefrontal cortex (mPfC) activity represents information about the state of the world, including present behavior, such as decisions, and the immediate past, such as short-term memory. Unknown is whether information about different states of t... Read More about Activity Subspaces in Medial Prefrontal Cortex Distinguish States of the World.

Spectral estimation for detecting low-dimensional structure in networks using arbitrary null models (2021)
Journal Article

Discovering low-dimensional structure in real-world networks requires a suitable null model that defines the absence of meaningful structure. Here we introduce a spectral approach for detecting a network's low-dimensional structure, and the nodes tha... Read More about Spectral estimation for detecting low-dimensional structure in networks using arbitrary null models.

An ensemble code in medial prefrontal cortex links prior events to outcomes during learning (2018)
Journal Article

The prefrontal cortex is implicated in learning the rules of an environment through trial and error. But it is unclear how such learning is related to the prefrontal cortex’s role in short-term memory. Here we ask if the encoding of short-term memory... Read More about An ensemble code in medial prefrontal cortex links prior events to outcomes during learning.

The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis (2017)
Journal Article

Circadian clock is known to adapt to environmental changes and can significantly influence cognitive and physiological functions. In this work, we report specific behavioral, cognitive, and sleep homeostatic defects in the after hours (Afh) circadian... Read More about The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis.

Working-for-Food Behaviors: A Preclinical Study in Prader-Willi Mutant Mice (2016)
Journal Article

Abnormal feeding behavior is one of the main symptoms of Prader-Willi syndrome (PWS). By studying a PWS mouse mutant line, which carries a paternally inherited deletion of the small nucleolar RNA 116 (Snord116), we observed significant changes in w... Read More about Working-for-Food Behaviors: A Preclinical Study in Prader-Willi Mutant Mice.

The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice (2016)
Journal Article

An AT motif-dependent axis, modulated by the transcription factor Zfhx3, influences the circadian clock in mice. In particular, gain of function of Zfhx3 significantly shortens circadian rhythms and alters the transcriptional activity of an important... Read More about The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice.

TAAR1 Modulates Cortical Glutamate NMDA Receptor Function (2015)
Journal Article

Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor expressed in the mammalian brain and known to influence subcortical monoaminergic transmission. Monoamines, such as dopamine, also play an important role within the prefrontal... Read More about TAAR1 Modulates Cortical Glutamate NMDA Receptor Function.

Dominant ?-catenin mutations cause intellectual disability with recognizable syndromic features (2014)
Journal Article