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Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice

Maggi, Silvia; Bon, Carlotta; Gustincich, Stefano; Tucci, Valter; Gainetdinov, Raul R.; Espinoza, Stefano


Carlotta Bon

Stefano Gustincich

Valter Tucci

Raul R. Gainetdinov

Stefano Espinoza


Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain serotonin functions and emotional behaviours. However, most of its functions remain undiscovered. Given the role of serotonin and limbic regions in some aspects of cognition, we used a temporal decision-making task to unveil a possible role of TAAR5 in cognitive processes. We found that TAAR5 knock-out mice showed a generally better performance due to a reduced number of errors and displayed a greater rate of improvement at the task than WT littermates. However, task-related parameters, such as time accuracy and uncertainty have not changed significantly. Overall, we show that TAAR5 modulates specific domains of cognition, highlighting a new role in brain physiology.


Maggi, S., Bon, C., Gustincich, S., Tucci, V., Gainetdinov, R. R., & Espinoza, S. (2022). Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice. Scientific Reports, 12, Article 14708.

Journal Article Type Article
Acceptance Date Aug 22, 2022
Online Publication Date Aug 29, 2022
Publication Date Aug 29, 2022
Deposit Date Oct 3, 2022
Publicly Available Date Oct 4, 2022
Journal Scientific Reports
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 12
Article Number 14708
Keywords Multidisciplinary
Public URL
Publisher URL


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