Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice

Maggi, Silvia; Bon, Carlotta; Gustincich, Stefano; Tucci, Valter; Gainetdinov, Raul R.; Espinoza, Stefano

Abstract

Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain serotonin functions and emotional behaviours. However, most of its functions remain undiscovered. Given the role of serotonin and limbic regions in some aspects of cognition, we used a temporal decision-making task to unveil a possible role of TAAR5 in cognitive processes. We found that TAAR5 knock-out mice showed a generally better performance due to a reduced number of errors and displayed a greater rate of improvement at the task than WT littermates. However, task-related parameters, such as time accuracy and uncertainty have not changed significantly. Overall, we show that TAAR5 modulates specific domains of cognition, highlighting a new role in brain physiology.

Citation

Maggi, S., Bon, C., Gustincich, S., Tucci, V., Gainetdinov, R. R., & Espinoza, S. (2022). Improved cognitive performance in trace amine-associated receptor 5 (TAAR5) knock-out mice. Scientific Reports, 12, Article 14708. https://doi.org/10.1038/s41598-022-18924-z

• Journal Article Type: Article
• Acceptance Date: Aug 22, 2022
• Online Publication Date: Aug 29, 2022
• Publication Date: Aug 29, 2022
• Deposit Date: Oct 3, 2022
• Publicly Available Date: Oct 4, 2022
• Journal: Scientific Reports
• Electronic ISSN: 2045-2322
• Publisher: Springer Science and Business Media LLC
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Article Number: 14708
• DOI: https://doi.org/10.1038/s41598-022-18924-z
• Keywords: Multidisciplinary
• Public URL: https://nottingham-repository.worktribe.com/output/10907106
• Publisher URL: https://www.nature.com/articles/s41598-022-18924-z