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The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis

Maggi, Silvia; Balzani, Edoardo; Lassi, Glenda; Garcia-Garcia, Celina; Plano, Andrea; Espinoza, Stefano; Mus, Liudmila; Tinarelli, Federico; Nolan, Patrick M.; Gainetdinov, Raul R.; Balci, Fuat; Nieus, Thierry; Tucci, Valter

The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis Thumbnail


Authors

Edoardo Balzani

Glenda Lassi

Celina Garcia-Garcia

Andrea Plano

Stefano Espinoza

Liudmila Mus

Federico Tinarelli

Patrick M. Nolan

Raul R. Gainetdinov

Fuat Balci

Thierry Nieus

Valter Tucci



Abstract

Circadian clock is known to adapt to environmental changes and can significantly influence cognitive and physiological functions. In this work, we report specific behavioral, cognitive, and sleep homeostatic defects in the after hours (Afh) circadian mouse mutant, which is characterized by lengthened circadian period. We found that the circadian timing irregularities in Afh mice resulted in higher interval timing uncertainty and suboptimal decisions due to incapability of processing probabilities. Our phenotypic observations further suggested that Afh mutants failed to exhibit the necessary phenotypic plasticity for adapting to temporal changes at multiple time scales (seconds-to-minutes to circadian). These behavioral effects of Afh mutation were complemented by the specific disruption of the Per/Cry circadian regulatory complex in brain regions that govern food anticipatory behaviors, sleep, and timing. We derive statistical predictions, which indicate that circadian clock and sleep are complementary processes in controlling behavioral/cognitive performance during 24 hrs. The results of this study have pivotal implications for understanding how the circadian clock modulates sleep and behavior.

Citation

Maggi, S., Balzani, E., Lassi, G., Garcia-Garcia, C., Plano, A., Espinoza, S., …Tucci, V. (2017). The after-hours circadian mutant has reduced phenotypic plasticity in behaviors at multiple timescales and in sleep homeostasis. Scientific Reports, 7(1), 1-18. https://doi.org/10.1038/s41598-017-18130-2

Journal Article Type Article
Acceptance Date Dec 6, 2017
Online Publication Date Dec 19, 2017
Publication Date 2017-12
Deposit Date Nov 5, 2019
Publicly Available Date Nov 5, 2019
Journal Scientific Reports
Electronic ISSN 2045-2322
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Issue 1
Article Number 17765
Pages 1-18
DOI https://doi.org/10.1038/s41598-017-18130-2
Public URL https://nottingham-repository.worktribe.com/output/3058202
Publisher URL https://www.nature.com/articles/s41598-017-18130-2
Contract Date Nov 5, 2019

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