All Outputs (26)

Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice (2022)
Journal Article
Morgan, H. L., Furse, S., Dias, I. H. K., Shabir, K., Castellanos, M., Khan, I., …Watkins, A. J. (2022). Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice. Communications Biology, 5(1), Article 929. https://doi.org/10.1038/s42003-022-03914-8

The underlying mechanisms driving paternally-programmed metabolic disease in offspring remain poorly defined. We fed male C57BL/6 mice either a control normal protein diet (NPD; 18% protein) or an isocaloric low protein diet (LPD; 9% protein) for a m... Read More about Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice.

Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism (2022)
Journal Article
Wood, J., Abdelrazig, S., Evseev, S., Ortori, C., Castellanos-Uribe, M., May, S. T., …Rahman, R. (2022). Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism. Cancers, 14(16), Article 3873. https://doi.org/10.3390/cancers14163873

Poor outcomes associated with diffuse high-grade gliomas occur in both adults and children, despite substantial progress made in the molecular characterisation of the disease. Targeting the metabolic requirements of cancer cells represents an alterna... Read More about Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism.

CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity (2021)
Journal Article
Rusu, A. D., Cornhill, Z. E., Coutiño, B. C., Uribe, M. C., Lourdusamy, A., Markus, Z., …Georgiou, M. (2021). CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity. Open Biology, 11(9), Article 210077. https://doi.org/10.1098/rsob.210077

Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established role... Read More about CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity.

Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation (2021)
Journal Article
Suthaporn, S., Jayaprakasan, K., Thornton, J. G., Walker, K. F., Castellanos, M., May, S., …Maalouf, W. E. (2021). Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation. Molecular and Cellular Endocrinology, 528, Article 111242. https://doi.org/10.1016/j.mce.2021.111242

This study aimed to evaluate the influence of progesterone (concentration and time of exposure) on endometrial decidualisation using an in vitro model cell line: Human Endometrial Stromal Cells (HESCs). HESCs exposed to progesterone (1 and 10 μM) had... Read More about Evaluating the influence of progesterone concentration and time of exposure on in vitro endometrial decidualisation.

TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma (2020)
Journal Article
Clifford, R. L., Yang, C. X., Fishbane, N., Patel, J., MacIsaac, J. L., McEwen, L. M., …Hackett, T. L. (2020). TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma. Clinical Epigenetics, 12(1), Article 145. https://doi.org/10.1186/s13148-020-00931-4

© 2020 The Author(s). Background: Mesenchymal fibroblasts are ubiquitous cells that maintain the extracellular matrix of organs. Within the lung, airway and parenchymal fibroblasts are crucial for lung development and are altered with disease, but it... Read More about TWIST1 DNA methylation is a cell marker of airway and parenchymal lung fibroblasts that are differentially methylated in asthma.

How to build an effective research network: Lessons from two decades of the GARNet plant science community (2020)
Journal Article
Parry, G., Benitez-Alfonso, Y., Gibbs, D. J., Grant, M., Harper, A., Harrison, C. J., …Murray, J. (2020). How to build an effective research network: Lessons from two decades of the GARNet plant science community. Journal of Experimental Botany, 71(22), 6881-6889. https://doi.org/10.1093/jxb/eraa397

Successful collaborative research is dependent on excellent ideas and innovative experimental approaches, as well as the provision of appropriate support networks. Collaboration requires venues, infrastructures, training facilities, and, perhaps most... Read More about How to build an effective research network: Lessons from two decades of the GARNet plant science community.

Current status of the multinational Arabidopsis community (2020)
Journal Article
Parry, G., Provart, N. J., Brady, S. M., Uzilday, B., Adams, K., Araújo, W., …The Multinational Arabidopsis Steering Committee. (2020). Current status of the multinational Arabidopsis community. Plant Direct, 4(7), https://doi.org/10.1002/pld3.248

© 2020 The Authors. Plant Direct published by American Society of Plant Biologists and the Society for Experimental Biology and John Wiley & Sons Ltd The multinational Arabidopsis research community is highly collaborative and over the past thirty... Read More about Current status of the multinational Arabidopsis community.

A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion (2020)
Journal Article
Canales Coutino, B., Cornhill, Z. E., Couto, A., Mack, N. A., Rusu, A. D., Nagarajan, U., …Georgiou, M. (2020). A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion. iScience, 23(6), Article 101237. https://doi.org/10.1016/j.isci.2020.101237

© 2020 The Authors Metastasis is the leading cause of death for patients with cancer. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumor growth toward malignancy. Advances in... Read More about A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion.

Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells (2019)
Journal Article
Ahmed, M., Jinks, N., Babaei-Jadidi, R., Kashfi, H., Castellanos-Uribe, M., May, S. T., …Nateri, A. S. (2019). Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells. Cancers, 12(1), Article 106. https://doi.org/10.3390/cancers12010106

Tumour-promoting inflammation is involved in colorectal cancer (CRC) development and therapeutic resistance. However, the antibiotics and antibacterial drugs and signalling that regulate the potency of anticancer treatment upon forced differentiation... Read More about Repurposing Antibacterial AM404 as a Potential Anticancer Drug for Targeting Colorectal Cancer Stem-Like Cells.

Arabidopsis bioinformatics resources: the current state, challenges, and priorities for the future (2019)
Journal Article
Doherty, C., Friesner, J., Gregory, B., Loraine, A., Megraw, M., Meyers, B., …Wurtele, E. (2019). Arabidopsis bioinformatics resources: the current state, challenges, and priorities for the future. Plant Direct, 3(1), Article e00109. https://doi.org/10.1002/pld3.109

Effective research, education, and outreach efforts by the Arabidopsis thaliana community, as well as other scientific communities that depend on Arabidopsis resources, depend vitally on easily available and publicly-shared resources. These resources... Read More about Arabidopsis bioinformatics resources: the current state, challenges, and priorities for the future.

Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using μ-XRF imaging and inductively coupled plasma mass spectrometry (2018)
Journal Article
Al-sandaqchi, A. T., Brignell, C., Collingwood, J. F., Geraki, K., Mirkes, E. M., Kong, K., …Elsheikha, H. M. (2018). Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using μ-XRF imaging and inductively coupled plasma mass spectrometry. Metallomics, 1401-1414. https://doi.org/10.1039/C8MT00136G

In this study, we measured the levels of elements in human brain microvascular endothelial cells (ECs) infected with T. gondii. ECs were infected with tachyzoites of the RH strain, and at 6, 24, and 48 hours post infection (hpi), the intracellular co... Read More about Metallome of cerebrovascular endothelial cells infected with Toxoplasma gondii using μ-XRF imaging and inductively coupled plasma mass spectrometry.

A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells (2017)
Journal Article
Al-Asadi, M. G., Brindle, G., Castellanos, M., May, S., Mills, K. I., Russell, N., …Pallis, M. (2017). A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells. Oncotarget, 8(67), 111405-111418. https://doi.org/10.18632/oncotarget.22808

Dormant leukaemia initiating cells in the bone marrow niche are a crucial therapeutic target for total eradication of acute myeloid leukaemia. To study this cellular subset we created and validated an in vitro model employing the cell line TF-1a, tre... Read More about A molecular signature of dormancy in CD34+CD38- acute myeloid leukaemia cells.

A cross-species gene expression marker-based genetic map and QTL analysis in bambara groundnut (2017)
Journal Article
Chai, H., Ho, W., Graham, N., May, S., Massawe, F., & Mayes, S. (2017). A cross-species gene expression marker-based genetic map and QTL analysis in bambara groundnut. Genes, 8(3), https://doi.org/10.3390/genes8020084

Bambara groundnut (Vigna subterranea (L.) Verdc.) is an underutilised legume crop, which has long been recognised as a protein-rich and drought-tolerant crop, used extensively in Sub-Saharan Africa. The aim of the study was to identify quantitative t... Read More about A cross-species gene expression marker-based genetic map and QTL analysis in bambara groundnut.

Brevicoryne brassicae aphids interfere with transcriptome responses of Arabidopsis thaliana to feeding by Plutella xylostella caterpillars in a density‑dependent manner (2016)
Journal Article
Kroes, A., Broekgaarden, C., Castellanos Uribe, M., May, S., van Loon, J. J., & Dicke, M. (2017). Brevicoryne brassicae aphids interfere with transcriptome responses of Arabidopsis thaliana to feeding by Plutella xylostella caterpillars in a density‑dependent manner. Oecologia, 183(1), 107-120. https://doi.org/10.1007/s00442-016-3758-3

Plants are commonly attacked by multiple herbivorous species. Yet, little is known about transcriptional patterns underlying plant responses to multiple insect attackers feeding simultaneously. Here, we assessed= transcriptomic responses of Arabidops... Read More about Brevicoryne brassicae aphids interfere with transcriptome responses of Arabidopsis thaliana to feeding by Plutella xylostella caterpillars in a density‑dependent manner.

Brassinosteroids participate in the control of basal and acquired freezing tolerance of plants (2016)
Journal Article
Eremina, M., Unterholzner, S. J., Rathnayake, A. I., Castellanos, M., Khan, M., Kugler, K. G., …Poppenberger, B. (2016). Brassinosteroids participate in the control of basal and acquired freezing tolerance of plants. Proceedings of the National Academy of Sciences, 113(40), Article E5982-E5991. https://doi.org/10.1073/pnas.1611477113

Brassinosteroids (BRs) are growth-promoting plant hormones that play a role in abiotic stress responses, but molecular modes that enable this activity remain largely unknown. Here we show that BRs participate in the regulation of freezing tolerance.... Read More about Brassinosteroids participate in the control of basal and acquired freezing tolerance of plants.

Gene pathway development in human epicardial adipose tissue during early life (2016)
Journal Article
Ojha, S., Fainberg, H. P., Wilson, V., Pelella, G., Castellanos, M., May, S., …Budge, H. (in press). Gene pathway development in human epicardial adipose tissue during early life. JCI insight, 1(13), Article e87460. https://doi.org/10.1172/jci.insight.87460

Studies in rodents and newborn humans demonstrate the influence of brown adipose tissue (BAT) in temperature control and energy balance and a critical role in the regulation of body weight. Here, we obtained samples of epicardial adipose tissue (EAT)... Read More about Gene pathway development in human epicardial adipose tissue during early life.

The study of progesterone action in human myometrial explants (2016)
Journal Article
Georgiou, E., Lei, K., Lai, P., Yulia, A., Herbert, B., Castellanos, M., …Johnson, M. (in press). The study of progesterone action in human myometrial explants. Molecular Human Reproduction, 22(8), https://doi.org/10.1093/molehr/gaw037

Study hypothesis: Myometrial explants represent a superior model compared with cell culture models for the study of human myometrial progesterone (P4) signalling in parturition. Study finding: Gene expression analysis showed myometrial explants clos... Read More about The study of progesterone action in human myometrial explants.

The small molecule hyperphyllin enhances leaf formation rate and mimics shoot meristem integrity defects associated with AMP1 deficiency (2016)
Journal Article

ALTERED MERISTEM PROGRAM1 (AMP1) is a member of the M28 family of carboxypeptidases with a pivotal role in plant development and stress adaptation. Its most prominent mutant defect is a unique hypertrophic shoot phenotype combining a strongly increas... Read More about The small molecule hyperphyllin enhances leaf formation rate and mimics shoot meristem integrity defects associated with AMP1 deficiency.

Teaching Data Science and Cloud Computing in Low and Middle Income Countries (2015)
Journal Article
Shanahan, H., Harrison, A., & May, S. T. (2015). Teaching Data Science and Cloud Computing in Low and Middle Income Countries. Advanced Techniques in Biology & Medicine, 3(3), Article 150. https://doi.org/10.4172/2379-1764.1000150

Large, publicly available data sets present a challenge and an opportunity for researchers based in Low and Middle Income Countries (LMIC). The challenge for these researchers is how they can make use of such data sets given their poor connectivity a... Read More about Teaching Data Science and Cloud Computing in Low and Middle Income Countries.

The mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana (2015)
Journal Article
Seguela-Arnaud, M., Smith, C., Castellanos Uribe, M., May, S., Fischl, H., McKenzie, N., & Bevan, M. W. (2015). The mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana. BMC Plant Biology, 15(1), Article 215. https://doi.org/10.1186/s12870-015-0592-4

Background: Plant cell walls are dynamic structures involved in all aspects of plant growth, environmental interactions and defense responses, and are the most abundant renewable source of carbon-containing polymers on the planet. To balance rigidity... Read More about The mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana.