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CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity

Rusu, Alexandra D.; Cornhill, Zoe E.; Coutiño, Brenda Canales; Uribe, Marcos Castellanos; Lourdusamy, Anbarasu; Markus, Zsuzsa; May, Sean T.; Rahman, Ruman; Georgiou, Marios

CG7379 and ING1 suppress cancer cell invasion by maintaining cell–cell junction integrity Thumbnail


Alexandra D. Rusu

Zoe E. Cornhill

Brenda Canales Coutiño

Marcos Castellanos Uribe

Zsuzsa Markus


Approximately 90% of cancer-related deaths can be attributed to a tumour's ability to spread. We have identified CG7379, the fly orthologue of human ING1, as a potent invasion suppressor. ING1 is a type II tumour suppressor with well-established roles in the transcriptional regulation of genes that control cell proliferation, response to DNA damage, oncogene-induced senescence and apoptosis. Recent work suggests a possible role for ING1 in cancer cell invasion and metastasis, but the molecular mechanism underlying this observation is lacking. Our results show that reduced expression of CG7379 promotes invasion in vivo in Drosophila, reduces the junctional localization of several adherens and septate junction components, and severely disrupts cell-cell junction architecture. Similarly, ING1 knockdown significantly enhances invasion in vitro and disrupts E-cadherin distribution at cell-cell junctions. A transcriptome analysis reveals that loss of ING1 affects the expression of several junctional and cytoskeletal modulators, confirming ING1 as an invasion suppressor and a key regulator of cell-cell junction integrity.

Journal Article Type Article
Acceptance Date Jul 26, 2021
Online Publication Date Sep 8, 2021
Publication Date 2021-09
Deposit Date Mar 4, 2022
Publicly Available Date Mar 7, 2022
Journal Open Biology
Electronic ISSN 2046-2441
Peer Reviewed Peer Reviewed
Volume 11
Issue 9
Article Number 210077
Keywords General Biochemistry, Genetics and Molecular Biology; Immunology; General Neuroscience
Public URL
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