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All Outputs (98)

Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial (2017)
Journal Article
Flaherty, K., Bath, P. M., Dineen, R., Law, Z., Scutt, P., Pocock, S., & Sprigg, N. (in press). Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial. Trials, 18(1), Article 607. https://doi.org/10.1186/s13063-017-2341-5

Rationale

Aside from blood pressure lowering, treatment options for intracerebral haemorrhage remain limited and a proportion of patients will undergo early haematoma expansion with resultant significant morbidity and mortality. Tranexamic acid (T... Read More about Statistical analysis plan for the ‘Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage’ (TICH-2) trial.

Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS) (2017)
Journal Article
Krishnan, K., Beishon, L., Berge, E., Christensen, H., Dineen, R. A., Ozturk, S., Sprigg, N., Wardlow, J. M., & Bath, P. M. (2018). Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS). International Journal of Stroke, 13(4), https://doi.org/10.1177/1747493017744463

Background and purpose: Although poor prognosis after intracerebral haemorrhage relates to risk factors and haematoma characteristics, there is limited evidence for the effect of race-ethnicity.
Methods: Data from 1011 patients with intracerebral ha... Read More about Relationship between race and outcome in Asian, Black and Caucasian patients with spontaneous intracerebral haemorrhage: data from the Virtual International Stroke Trials Archive (VISTA) and Efficacy of Nitric Oxide in Stroke trial (ENOS).

Altered whole-brain connectivity in albinism (2016)
Journal Article
Welton, T., Ather, S., Proudlock, F. A., Gottlob, I., & Dineen, R. A. (2017). Altered whole-brain connectivity in albinism. Human Brain Mapping, 38(2), 740-752. https://doi.org/10.1002/hbm.23414

Albinism is a group of congenital disorders of the melanin synthesis pathway. Multiple ocular, white matter and cortical abnormalities occur in albinism, including a greater decussation of nerve fibres at the optic chiasm, foveal hypoplasia and nysta... Read More about Altered whole-brain connectivity in albinism.

Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization (2016)
Journal Article
Alshuft, H., Condon, L., Dineen, R. A., & Auer, D. P. (in press). Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization. PLoS ONE, 11(9), Article e0161687. https://doi.org/10.1371/journal.pone.0161687

Objective

This study investigates associations between cortical thickness and pain duration, and central sensitization as markers of pain progression in painful knee osteoarthritis.

Methods

Whole brain cortical thickness and pressure pain th... Read More about Cerebral cortical thickness in chronic pain due to knee osteoarthritis: the effect of pain duration and pain densitization.

Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease (2016)
Journal Article
Meng, D., Hosseini, A. A., Simpson, R. J., Shaikh, Q., Tench, C. R., Dineen, R. A., & Auer, D. P. (2017). Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease. Radiology, 282(2), 502-515. https://doi.org/10.1148/radiol.2016152685

Purpose: To investigate associations between neuroimaging markers of cerebrovascular disease, including lesion topography and extent and severity of strategic and global cerebral tissue injury, and cognition in carotid artery disease (CAD).
Material... Read More about Lesion topography and microscopic white matter tract damage contribute to cognitive impairment in symptomatic carotid artery disease.

Animated educational video to prepare children for MRI without sedation: evaluation of the appeal and value (2016)
Journal Article
Szeszak, S., Man, R., Love, A., Langmack, G., Wharrad, H., & Dineen, R. A. (2016). Animated educational video to prepare children for MRI without sedation: evaluation of the appeal and value. Pediatric Radiology, 46(12), 1744-1750. https://doi.org/10.1007/s00247-016-3661-4

Background: MRI scans can be distressing for children and often require sedation. Educating children about what to expect reduces anxiety and increases likelihood of successful non-sedated MRI scans. Multimedia tools are a popular means of education.... Read More about Animated educational video to prepare children for MRI without sedation: evaluation of the appeal and value.

Development and clinical acceptability of a pre-operative risk stratification tool of cerebellar mutism syndrome in children with posterior fossa tumour (2016)
Presentation / Conference Contribution
Dineen, R. A., Avula, S., Chambers, T., Dutta, M., Liu, J., Soria, D., Quinlan, P., MacArthur, D., Howart, S., Harave, S., Ong, C., Mallucci, C., Kumar, R., Pizer, B., & Walker, D. Development and clinical acceptability of a pre-operative risk stratification tool of cerebellar mutism syndrome in children with posterior fossa tumour. Presented at 2016 Royal College of Paediatrics and Child Health annual conference

Aims: Despite identification of numerous pre-operative cerebellar mutism syndrome (CMS) clinical and radiological predictors, a unifying pre-operative risk stratification model for use during surgical consent is currently lacking. The aims of the pro... Read More about Development and clinical acceptability of a pre-operative risk stratification tool of cerebellar mutism syndrome in children with posterior fossa tumour.

Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial (2016)
Journal Article
Krishnan, K., Scutt, P., Woodhouse, L., Bath, P. M., Adami, A., Becker, J. L., Cala, L. A., Casado, A. M., Chen, C., Dineen, R. A., Gommans, J., Koumellis, P., Christensen, H., Collins, R., Czlonkowska, A., Lees, K. R., Ntaios, G., Ozturk, S., Phillips, S. J., Sprigg, N., …Bath, P. M. (2016). Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial. Journal of Stroke and Cerebrovascular Diseases, 25(5), 1017-1026. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.010

Background and purpose: More than 50% of patients with acute intracerebral haemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, whether to continue or... Read More about Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial.

Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis (2015)
Journal Article
Krishnan, K., Scutt, P., Woodhouse, L. J., Adami, A., Becker, J. L., Berge, E., Cala, L. A., Casado, A. M., Caso, V., Chen, C., Christensen, H., Collins, R., Czlonkowska, A., Dineen, R. A., Gommans, J., Koumellis, P., Lees, K. R., Ntaios, G., Ozturk, S., Phillips, S. J., …Bath, P. M. (in press). Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis. Stroke, 47(1), 44-52. https://doi.org/10.1161/strokeaha.115.010368

Background and purpose: The Efficacy of Nitric oxide in Stroke (ENOS) trial found that transdermal glyceryl trinitrate (GTN, a nitric oxide donor) lowered blood pressure but did not improve functional outcome in patients with acute stroke. However, G... Read More about Glyceryl Trinitrate for Acute Intracerebral Hemorrhage: Results From the Efficacy of Nitric Oxide in Stroke (ENOS) Trial, a Subgroup Analysis.

Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence (2015)
Journal Article
Mougin, O., Abdel-Fahim, R., Dineen, R., Pitiot, A., Evangelou, N., & Gowland, P. (2016). Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence. Magnetic Resonance in Medicine, 76(5), 1512-1516. https://doi.org/10.1002/mrm.26061

Purpose

To present an improved three-dimensional (3D) interleaved phase sensitive inversion recovery (PSIR) sequence including a concomitantly acquired new contrast, null point imaging (NPI), to help detect and classify abnormalities in cortical g... Read More about Imaging gray matter with concomitant null point imaging from the phase sensitive inversion recovery sequence.

Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388) (2015)
Journal Article
Beridze, M., Christensen, H., Dineen, R. A., Duley, L., Heptinstall, S., James, M., Markus, H., Pocock, S., Ranta, A., Robinson, T., Nikola, N., Venables, G., & Bath, P. M. (2015). Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388). International Journal of Stroke, 10(7), https://doi.org/10.1111/ijs.12538

RATIONALE:

The risk of recurrence following a stroke or transient ischemic attack is high, especially immediately after the event.
HYPOTHESIS:

Because two antiplatelet agents are superior to one in patients with non-cardioembolic events, more... Read More about Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388).

Reproducibility of graph-theoretic brain network metrics: a systematic review (2015)
Journal Article
Welton, T., Kent, D., Auer, D. P., & Dineen, R. A. (2015). Reproducibility of graph-theoretic brain network metrics: a systematic review. Brain Connectivity, 5(4), 193-202. https://doi.org/10.1089/brain.2014.0313

This systematic review aimed to assess the reproducibility of graph-theoretic brain network metrics. Primary research studies of test-retest reliability conducted on healthy human subjects were included that quantified test-retest reliability using e... Read More about Reproducibility of graph-theoretic brain network metrics: a systematic review.

Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial (2015)
Journal Article
Krishnan, K., Mukhtar, S. F., Dineen, R., Lingard, J., Houlton, A., Walker, E., Jones, T., Sprigg, N., Cala, L. A., Becker, J. L., Koumellis, P., Adami, A., Casado, A. M., Bath, P. M., & Wardlaw, J. M. (2015). Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial. Journal of Neurology, Neurosurgery and Psychiatry, 86(11), 1258-1266. https://doi.org/10.1136/jnnp-2014-309845

Background: Poor prognosis after intracerebral haemorrhage (ICH) is related to haemorrhage characteristics. Along with developing therapeutic interventions, we sought to understand the performance of haemorrhage descriptors in large clinical trials.... Read More about Performance characteristics of methods for quantifying spontaneous intracerebral haemorrhage: data from the Efficacy of Nitric Oxide in Stroke (ENOS) trial.

Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis (2014)
Journal Article
Welton, T., Kent, D., Constantinescu, C. S., Auer, D. P., & Dineen, R. A. (2015). Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis. Radiology, 275(1), 89-96. https://doi.org/10.1148/radiol.14140925

Purpose

To identify statistical consensus between published studies for distribution and functional relevance of tract white matter (WM) degradation in multiple sclerosis (MS).
Materials and Methods

By systematically searching online databases... Read More about Functionally Relevant White Matter Degradation in Multiple Sclerosis: A Tract-based Spatial Meta-Analysis.

Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461) (2014)
Journal Article
a randomized controlled pilot trial (ISRCTN50867461). Journal of Stroke and Cerebrovascular Diseases, 23(6), 1312-1318. https://doi.org/10.1016/j.jstrokecerebrovasdis.2013.11.007

Background: Spontaneous intracerebral hemorrhage (ICH) can be devastating, particularly if hematoma expansion (HE) occurs. Tranexamic acid (TA), an antifibrinolytic drug, significantly reduced mortality in bleeding patients after trauma in the large... Read More about Tranexamic acid for spontaneous intracerebral hemorrhage: a randomized controlled pilot trial (ISRCTN50867461).

Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors (2013)
Journal Article
Rodriguez Gutierrez, D., Awwad, A., Meijer, L., Manita, M., Jaspan, T., Dineen, R. A., Grundy, R. G., & Auer, D. P. (in press). Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors. American Journal of Neuroradiology, 35(5), https://doi.org/10.3174/ajnr.A3784

BACKGROUND AND PURPOSE: Qualitative radiologic MR imaging review affords limited differentiation among types of pediatric posterior fossa brain tumors and cannot detect histologic or molecular subtypes, which could help to stratify treatment. This st... Read More about Metrics and textural features of MRI diffusion to improve classification of pediatric posterior fossa tumors.

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics (2013)
Journal Article
Rodriguez Gutierrez, D., Manita, M., Jaspan, T., Dineen, R. A., Grundy, R. G., & Auer, D. P. (in press). Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics. Neuro-Oncology, 15(8), https://doi.org/10.1093/neuonc/not034

Background

Assessment of treatment response by measuring tumor size is known to be a late and potentially confounded response index. Serial diffusion MRI has shown potential for allowing earlier and possibly more reliable response assessment in a... Read More about Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics.