Bacteriophage therapy to reduce Salmonella colonization of broiler chickens

Atterbury, Robert J.; Van Bergen, M.A.P.; Ortiz, F.; Lovell, M.A.; Harris, J.A.; De Boer, A.; Wagenaar, J.A.; Allen, V.M.; Barrow, P.A.

doi:10.1128/AEM.00049-07

Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections (2024)
Journal Article
Gigante, A. M., Hadis, M. A., Secker, B., Shaw, S. C., Cooper, P. R., Palin, W. M., Milward, M. R., & Atterbury, R. J. (2024). Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections. Frontiers in Microbiology, 15, 1-11. https://doi.org/10.3389/fmicb.2024.1414412

Introduction: Pseudomonas aeruginosa is a leading cause of canine otitis externa. Enrofloxacin is often applied topically to treat this condition, although recalcitrant and recurring infections are common. There is evidence that exposure to blue ligh... Read More about Exposure to blue light reduces antimicrobial resistant Pseudomonas aeruginosa isolated from dog ear infections.

Pseudomonas spp. in Canine Otitis Externa (2023)
Journal Article
Secker, B., Shaw, S., & Atterbury, R. J. (2023). Pseudomonas spp. in Canine Otitis Externa. Microorganisms, 11(11), Article 2650. https://doi.org/10.3390/microorganisms11112650

Canine otitis externa (OE) is a commonly diagnosed condition seen in veterinary practice worldwide. In this review, we discuss the mechanisms of the disease, with a particular focus on the biological characteristics of Pseudomonas aeruginosa and the... Read More about Pseudomonas spp. in Canine Otitis Externa.

Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions (2023)
Journal Article
Dlamini, S. B., Gigante, A. M., Hooton, S. P. T., & Atterbury, R. J. (2023). Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions. Microorganisms, 11(10), Article 2389. https://doi.org/10.3390/microorganisms11102389

Salmonella causes a range of diseases in humans and livestock of considerable public health and economic importance. Widespread antimicrobial use, particularly in intensively produced livestock (e.g., poultry and pigs) may contribute to the rise of m... Read More about Efficacy of Different Encapsulation Techniques on the Viability and Stability of Diverse Phage under Simulated Gastric Conditions.

Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli (2023)
Journal Article
Nicolas, M., Trotereau, A., Culot, A., Moodley, A., Atterbury, R., Wagemans, J., …Schouler, C. (2023). Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli. Microbiology Spectrum, 11(3), Article e04296-22. https://doi.org/10.1128/spectrum.04296-22

The increase in antibiotic-resistant avian-pathogenic Escherichia coli (APEC), the causative agent of colibacillosis in poultry, warrants urgent research and the development of alternative therapies. This study describes the isolation and characteriz... Read More about Isolation and Characterization of a Novel Phage Collection against Avian-Pathogenic Escherichia coli.

Prophylactic Delivery of a Bacteriophage Cocktail in Feed Significantly Reduces Salmonella Colonization in Pigs (2022)
Journal Article
Thanki, A. M., Mignard, G., Atterbury, R. J., Barrow, P., Millard, A. D., & Clokie, M. R. J. (2022). Prophylactic Delivery of a Bacteriophage Cocktail in Feed Significantly Reduces Salmonella Colonization in Pigs. Microbiology Spectrum, 10(3), e0042222. https://doi.org/10.1128/spectrum.00422-22

Nontyphoidal Salmonella spp. are a leading cause of human food poisoning and can be transmitted to humans via consuming contaminated pork. To reduce Salmonella spread to the human food chain, bacteriophage (phage) therapy could be used to reduce bact... Read More about Prophylactic Delivery of a Bacteriophage Cocktail in Feed Significantly Reduces Salmonella Colonization in Pigs.

Predatory bacteria as living antibiotics – where are we now? (2021)
Journal Article
Atterbury, R. J., & Tyson, J. (2021). Predatory bacteria as living antibiotics – where are we now?. Microbiology, 167(1), Article 001025. https://doi.org/10.1099/mic.0.001025

Antimicrobial resistance (AMR) is a global health and economic crisis. With too few antibiotics in development to meet current and anticipated needs, there is a critical need for new therapies to treat Gram-negative infections. One potential approach... Read More about Predatory bacteria as living antibiotics – where are we now?.

Viruses of protozoan parasites and viral therapy: Is the time now right? (2020)
Journal Article
Barrow, P., Dujardin, J. C., Fasel, N., Greenwood, A. D., Osterrieder, K., Lomonossoff, G., …Lalle, M. (2020). Viruses of protozoan parasites and viral therapy: Is the time now right?. Virology Journal, 17, Article 142. https://doi.org/10.1186/s12985-020-01410-1

Infections caused by protozoan parasites burden the world with huge costs in terms of human and animal health. Most parasitic diseases caused by protozoans are neglected, particularly those associated with poverty and tropical countries, but the pauc... Read More about Viruses of protozoan parasites and viral therapy: Is the time now right?.

Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius (2020)
Journal Article
Brown, H. L., Metters, G., Hitchings, M. D., Wilkinson, T. S., Sousa, L., Cooper, J., …Jenkins, R. (2020). Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius. Applied and Environmental Microbiology, 86(20), Article e01768-20. https://doi.org/10.1128/aem.01768-20

Staphylococcus pseudintermedius causes opportunistic infections in dogs. It also has significant zoonotic potential, with the emergence of multidrug-resistance leading to difficulty treating both animal and human infections. Manuka honey has previous... Read More about Antibacterial and anti-virulence activity of manuka honey against genetically diverse Staphylococcus pseudintermedius.

Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage (2020)
Journal Article
Atterbury, R. J., Gigante, A. M., Rubio Lozano, M. D. L. S., Méndez Medina, R. D., Robinson, G., Alloush, H., …Allen, V. M. (2020). Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage. Virology Journal, 17, Article 98. https://doi.org/10.1186/s12985-020-01368-0

Background: Enteric infections caused by Salmonella spp. remain a major public health burden worldwide. Chickens are known to be a major reservoir for this zoonotic pathogen. The presence of Salmonella in poultry farms and abattoirs is associated wit... Read More about Reduction of Salmonella contamination on the surface of chicken skin using bacteriophage.

An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom (2020)
Journal Article
Atterbury, R., Gigante, A., Tinker, D., Howell, M., & Allen, V. (2020). An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom. Journal of Applied Microbiology, 128(6), 1776-1784. https://doi.org/10.1111/jam.14576

© 2020 The Society for Applied Microbiology Aim: Following previous research on improving the cleaning of crates used to transport broiler chickens from the farm to the abattoir, a demonstration project was undertaken to investigate improvements in c... Read More about An improved cleaning system to reduce microbial contamination of poultry transport crates in the United Kingdom.

Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot (2020)
Journal Article
Hobley, L., Summers, J. K., Till, R., Milner, D. S., Atterbury, R. J., Stroud, A., …Sockett, R. E. (2020). Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot. Journal of Bacteriology, 202(6), Article e00629-19. https://doi.org/10.1128/JB.00629-19

Copyright © 2020 Hobley et al. Bacteria are preyed upon by diverse microbial predators, including bacteriophage and predatory bacteria, such as Bdellovibrio bacteriovorus. While bacteriophage are used as antimicrobial therapies in Eastern Europe and... Read More about Dual predation by bacteriophage and bdellovibrio bacteriovorus can eradicate escherichia coli prey in situations where single predation cannot.

Veterinary use of bacteriophage therapy in intensively-reared livestock (2019)
Journal Article
Gigante, A., & Atterbury, R. J. (2019). Veterinary use of bacteriophage therapy in intensively-reared livestock. Virology Journal, 16(1), Article 155. https://doi.org/10.1186/s12985-019-1260-3

Zoonoses are infectious diseases transmitted directly or indirectly between animals and humans. Several important zoonotic pathogens colonize farm animals asymptomatically, which may lead to contamination of the food chain and public health hazards.... Read More about Veterinary use of bacteriophage therapy in intensively-reared livestock.

Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal (2018)
Journal Article
Sarkar, B., Sarkar, S., Das, M., Bhowmick, T., Koley, H., Atterbury, R., & Chakrabarti, A. (2018). Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal. Journal of Global Infectious Diseases, 10(2), https://doi.org/10.4103/jgid.jgid_37_17

Objectives: We have isolated a total of five newer cholera phages which are novel broad host range to incorporate with the existing phage typing schemes for an extended typing scheme. Materials and Methods: These newly isolated phages were well chara... Read More about Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal.

Molecular epidemiology of nontyphoidal Salmonella in poultry and poultry products in India: implications for human health (2015)
Journal Article
Saravanan, S., Purushothaman, V., Murthy, T. R. G., Sukumar, K., Srinivasan, P., Gowthaman, V., …Kuchipudi, S. V. (2015). Molecular epidemiology of nontyphoidal Salmonella in poultry and poultry products in India: implications for human health. Indian Journal of Microbiology, 55(3), https://doi.org/10.1007/s12088-015-0530-z

Human infections with non-typhoidal Salmonella (NTS) serovars are increasingly becoming a threat to human health globally. While all motile Salmonellae have zoonotic potential, Salmonella Enteritidis and Salmonella Typhimurium are most commonly assoc... Read More about Molecular epidemiology of nontyphoidal Salmonella in poultry and poultry products in India: implications for human health.

Investigation into the animal species contents of popular wet pet foods (2015)
Journal Article
Maine, I. R., Atterbury, R. J., & Chang, K.-C. (2015). Investigation into the animal species contents of popular wet pet foods. Acta Veterinaria Scandinavica, 57(1), https://doi.org/10.1186/s13028-015-0097-z

Background: The use of the generic term “meat and animal derivatives” in declared ingredient lists of pet foods in the European Union is virtually universal. In the wake of the 2013 “horse meat scandal” in the human food chain, we examined the presen... Read More about Investigation into the animal species contents of popular wet pet foods.

Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria (2012)
Journal Article
Hobley, L., Lerner, T. R., Williams, L. E., Lambert, C., Till, R., Milner, D. S., …Sockett, R. E. (2012). Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria. BMC Genomics, 13(670), https://doi.org/10.1186/1471-2164-13-670

Background:

Evolution equipped Bdellovibrio bacteriovorus predatory bacteria to invade other bacteria, digesting and replicating, sealed within them thus preventing nutrient-sharing with organisms in the surrounding environment. Bdellovibrio were... Read More about Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria.

Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks (2011)
Journal Article
Atterbury, R. J., Hobley, L., Till, R., Lambert, C., Capeness, M. J., Lerner, T. R., …Sockett, R. E. (2011). Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks. Applied and Environmental Microbiology, 77(16), https://doi.org/10.1128/AEM.00426-11

Bdellovibrio bacteriovorus is a bacterium which preys upon and kills Gram-negative bacteria, including the zoonotic pathogens Escherichia coli and Salmonella. Bdellovibrio has potential as a biocontrol agent, but no reports of it being tested in livi... Read More about Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks.

Effect of delivery method on the efficacy of Salmonella vaccination in chickens (2010)
Journal Article
Atterbury, R. J., Morris, V., Harrison, D., Tucker, V., Allen, V., Davies, R., & Carrique-Mas, J. (2010). Effect of delivery method on the efficacy of Salmonella vaccination in chickens. Veterinary Record, 167(5), https://doi.org/10.1136/vr.b4884

To investigate whether the efficacy of live vaccines is influenced by the mode of vaccine delivery, a widely-used UK live commercial Salmonella Enteritidis vaccine was delivered to pullet chicks either by spray, in drinking water, or in combination w... Read More about Effect of delivery method on the efficacy of Salmonella vaccination in chickens.

An inside job: Bdellovibrio bacteriovorus (2008)
Journal Article
Sockett, L., Hobley, L., Fenton, A., Woods, R., Lambert, C., Chang, C. Y., …King, S. (2008). An inside job: Bdellovibrio bacteriovorus. Microbiology Today, 35(4), 184-187

Bacteriophage therapy to reduce Salmonella colonization of broiler chickens (2007)
Journal Article
Atterbury, R. J., Van Bergen, M., Ortiz, F., Lovell, M., Harris, J., De Boer, A., …Barrow, P. (2007). Bacteriophage therapy to reduce Salmonella colonization of broiler chickens. Applied and Environmental Microbiology, 73(14), https://doi.org/10.1128/AEM.00049-07

Acute enteric infections caused by salmonellas remain a major public health burden worldwide. Poultry, particularly chickens, are known to be the main reservoir for this zoonotic pathogen. Although some progress has been made in reducing Salmonella c... Read More about Bacteriophage therapy to reduce Salmonella colonization of broiler chickens.

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