Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study

Anand-Ivell, Ravinder; Cohen, Arieh; Norgaard-Pedersen, Bent; Joenssen, Bo; Bonde, Jens-Peter; Hougaard, David M.; Lindh, Christian; Toft, Gunnar; Lindhard, Morten; Ivell, Richard

doi:10.3389/fphys.2018.00406

All Outputs (6)

Insulin-Like Peptide 3 (INSL3) (2018)
Book Chapter

© 2019 Elsevier Inc. Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excell... Read More about Insulin-Like Peptide 3 (INSL3).

Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology (2018)
Journal Article

BACKGROUND Insulin-like peptide 3 (INSL3) is a member of the relaxin family of neohormones which has evolved to address specifically mammalian aspects of reproduction related to viviparity and internal fertilization. It was originally identified as... Read More about Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology.

Testicular function and bone in young men with severe childhood-onset obesity. (2018)
Journal Article

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puber... Read More about Testicular function and bone in young men with severe childhood-onset obesity..

Oxytocin (2018)
Book Chapter

The small peptide hormone oxytocin has long been recognized as a key factor in the natural induction of the birth process at the end of pregnancy, as well as in the release of milk upon suckling by the infant. It has additional roles within the brain... Read More about Oxytocin.

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum (2018)
Journal Article

BACKGROUND: The circulating level of the peptide hormone insulin-like factor 3 (INSL3) is a promising diagnostic marker reflecting Leydig cell function in the male. Few commercial immunoassays of varying quality exist. Therefore, we decided to devel... Read More about Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum.

Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study (2018)
Journal Article

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccess... Read More about Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study.