Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study

Anand-Ivell, Ravinder; Cohen, Arieh; Norgaard-Pedersen, Bent; Joenssen, Bo; Bonde, Jens-Peter; Hougaard, David M.; Lindh, Christian; Toft, Gunnar; Lindhard, Morten; Ivell, Richard

doi:10.3389/fphys.2018.00406

All Outputs (4)

Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology (2018)
Journal Article

BACKGROUND Insulin-like peptide 3 (INSL3) is a member of the relaxin family of neohormones which has evolved to address specifically mammalian aspects of reproduction related to viviparity and internal fertilization. It was originally identified as... Read More about Insulin-like peptide 3 (INSL3) is a major regulator of female reproductive physiology.

Testicular function and bone in young men with severe childhood-onset obesity. (2018)
Journal Article

Background: Previous studies suggest increased risk for hypoandrogenism and fractures in men with obesity. We aimed to describe the effects of severe childhood-onset obesity on the cross talk between metabolic state, testes and skeleton at late puber... Read More about Testicular function and bone in young men with severe childhood-onset obesity..

Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum (2018)
Journal Article

BACKGROUND: The circulating level of the peptide hormone insulin-like factor 3 (INSL3) is a promising diagnostic marker reflecting Leydig cell function in the male. Few commercial immunoassays of varying quality exist. Therefore, we decided to devel... Read More about Development and validation of a mass spectrometry-based assay for quantification of insulin-like factor 3 in human serum.

Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study (2018)
Journal Article

The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccess... Read More about Amniotic fluid INSL3 measured during the critical time window in human pregnancy relates to cryptorchidism, hypospadias and phthalate load: a large case-control study.