All Outputs (215)

Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review (2009)
Journal Article

Background: Granulocyte-colony stimulating factor (G-CSF) shows promise as a treatment for stroke. This systematic review assesses G-CSF in experimental ischaemic stroke. Methods: Relevant studies were identified with searches of Medline, Embase and... Read More about Granulocyte-colony stimulating factor in experimental stroke and its effects on infarct size and functional outcome: a systematic review.

Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression (2009)
Journal Article

Both low and high blood pressure (BP) during the acute phase of stroke are associated independently with a poor outcome. Several small clinical trials have involved the alteration of BP and this study assessed the relationship between change in BP an... Read More about Relationship between therapeutic changes in blood pressure and outcomes in acute stroke: a metaregression.

Antiplatelet activity should be measured routinely: no (2009)
Journal Article

Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration (2009)
Journal Article

Background and Purpose—High blood pressure (BP) is associated independently with poor outcome after acute ischemic stroke, although in most analyses “baseline” BP was measured 24 hours or more postictus, and not during the hyperacute period. Methods... Read More about Relationship between hyperacute blood pressure and outcome after ischemic stroke: data from the VISTA Collaboration.

Thigh-length compression stockings and DVT after stroke (2009)
Journal Article

Speeding stroke recovery? A systematic review of amphetamine after stroke (2009)
Journal Article

Introduction: The use of drugs to enhance recovery (“rehabilitation pharmacology”) has been assessed. Amphetamine can improve outcome in experimental models of stroke, and several small clinical trials have assessed its use in stroke. Methods: Elec... Read More about Speeding stroke recovery? A systematic review of amphetamine after stroke.

Need for ethics approval and patient consent in clinical research (2009)
Journal Article

Interventions for deliberately altering blood pressure in acute stroke (2009)
Journal Article

Good laboratory practice: preventing introduction of bias at the bench (2009)
Journal Article

Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Summary of Review—Accumulating evidence sugge... Read More about Good laboratory practice: preventing introduction of bias at the bench.

The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST) (2009)
Journal Article

Background and Purpose—High blood pressure (BP) is present in 80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the relationship between admission BP and acute CT findings. M... Read More about The relationship between baseline blood pressure and computed tomography findings in acute stroke: data from the Tinzaparin in Acute Ischaemic Stroke Trial (TAIST).

Systematic reviews as a tool for planning and interpreting trials (2009)
Journal Article

Background Systematic reviews followed by ameta-analysis are carried out in medical research to combine the results of two or more related studies. Stroke trials have struggled to show beneficial effects and meta-analysis should be used more widely... Read More about Systematic reviews as a tool for planning and interpreting trials.

Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk (2008)
Journal Article

Objectives: Our aim was to study the effect of combination therapy with aspirin and dipyridamole (A+D) over aspirin alone (ASA) in secondary prevention after transient ischemic attack or minor stroke of presumed arterial origin and to perform subgr... Read More about Dipyridamole plus aspirin versus aspirin alone in the secondary prevention after TIA or stroke: a meta-analysis by risk.

Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events (2008)
Journal Article

Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate of subsequent cardiovascular events, including str... Read More about Telmisartan to Prevent Recurrent Stroke and Cardiovascular Events.

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke (2008)
Journal Article

Background: Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extended release dipyridamole (ASA–ERDP) versus clopidogrel. Methods: In this... Read More about Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke.

Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials (2008)
Journal Article

Background and Purpose—Vascular prevention trials mostly count “yes/no” (binary) outcome events, eg, stroke/no stroke. Analysis of ordered categorical vascular events (eg, fatal stroke/nonfatal stroke/no stroke) is clinically relevant and could be... Read More about Use of ordinal outcomes in vascular prevention trials: comparison with binary outcomes in published trials.

Ordinal reanalysis of the SHEP Trial (2008)
Journal Article

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach (2008)
Journal Article

Background and Purpose: At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of experimental stroke studies. Using a metaepidemiolog... Read More about Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach.

Stroke outcome in clinical trial patients deriving from different countries (2008)
Journal Article

Background and Purpose—Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality, and stroke outcome across geographical locations rem... Read More about Stroke outcome in clinical trial patients deriving from different countries.

A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility (2008)
Journal Article

Background: Aspirin, dipyridamole and clopidogrel are effective in secondary vascular prevention. Combination therapy with three antiplatelet agents might maximise the benefit of antiplatelet treatment in the secondary prevention of ischaemic stroke.... Read More about A randomised controlled trial of triple antiplatelet therapy (Aspirin, Clopidogrel and Dipyridamole) in the secondary prevention of stroke: safety, tolerability and feasibility.

Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials (2008)
Journal Article

Background and Purpose—An early and reliable prognosis for recovery in stroke patients is important for initiation of individual treatment and for informing patients and relatives. We recently developed and validated models for predicting survival a... Read More about Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials.