All Outputs (30)

Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses (2023)
Journal Article

Non-structural protein 4 (NS4) of insect-borne and tick-borne orbiviruses is encoded by genome segment 9, from a secondary open reading frame. Though a protein dispensable for bluetongue virus (BTV) replication, it has been shown to counter the inter... Read More about Orbivirus NS4 Proteins Play Multiple Roles to Dampen Cellular Responses.

Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells (2023)
Journal Article

At least 12 serotypes of ‘atypical’ bluetongue virus (BTV-25 to BTV-36) have been identified to date. These atypical serotypes fail to infect/replicate in Culicoides-derived cell lines and/or adult Culicoides vectors and hence can no longer be transm... Read More about Uncovering the Underlying Mechanisms Blocking Replication of Bluetongue Virus Serotype 26 (BTV-26) in Culicoides Cells.

Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype (2023)
Journal Article

Bluetongue is an economically important disease of domesticated and wild ruminants caused by bluetongue virus (BTV). There are at least 36 different serotypes of BTV (the identity of which is determined by its outer-capsid protein VP2), most of which... Read More about Increased Clinical Signs and Mortality in IFNAR(−/−) Mice Immunised with the Bluetongue Virus Outer-Capsid Proteins VP2 or VP5, after Challenge with an Attenuated Heterologous Serotype.

Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells (2023)
Journal Article

Bioinformatic analyses have predicted that orbiviruses encode an additional, small non-structural protein (NS5) from a secondary open reading frame on genome segment 10. However, this protein has not previously been detected in infected mammalian or... Read More about Identification of Orbivirus Non-Structural Protein 5 (NS5), Its Role and Interaction with RNA/DNA in Infected Cells.

Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search (2022)
Journal Article

African horse sickness (AHS) is a vector-borne disease transmitted by Culicoides spp., endemic to sub-Saharan Africa. There have been many examples of historic and recent outbreaks in the Middle East, Asia and Europe. However, not much is known about... Read More about Re‐parameterization of a mathematical model of African horse sickness virus using data from a systematic literature search.

Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model (2021)
Journal Article

Bluetongue virus serotypes 1 to 24 are transmitted primarily by infected Culicoides midges, in which they also replicate. However, “atypical” BTV serotypes (BTV‐25, ‐26, ‐27 and ‐28) have recently been identified that do not infect and replicate in a... Read More about Identification of the Genome Segments of Bluetongue Virus Type 26/Type 1 Reassortants Influencing Horizontal Transmission in a Mouse Model.

Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes (2021)
Journal Article

Bluetongue (BT) is a severe and economically important disease of ruminants that is widely distributed around the world, caused by the bluetongue virus (BTV). More than 28 different BTV serotypes have been identified in serum neutralisation tests (SN... Read More about Serological Cross-Reactions between Expressed VP2 Proteins from Different Bluetongue Virus Serotypes.

Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved (2021)
Journal Article

Statin derivatives can inhibit the replication of a range of viruses, including hepatitis C virus (HCV, Hepacivirus), dengue virus (Flavivirus), African swine fever virus (Asfarviridae) and poliovirus (Picornaviridae). We assess the antiviral effect... Read More about Inhibition of Orbivirus Replication by Fluvastatin and Identification of the Key Elements of the Mevalonate Pathway Involved.

An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins (2021)
Journal Article

Arboviruses such as bluetongue virus (BTV) replicate in arthropod vectors involved in their transmission between susceptible vertebrate-hosts. The “classical” BTV strains infect and replicate effectively in cells of their insect-vectors (Culicoides b... Read More about An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins.

The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells (2020)
Journal Article

Mosquitoes are responsible for the transmission of many clinically important arboviruses that cause significant levels of annual mortality and socioeconomic health burden worldwide. Deciphering the mechanisms by which mosquitoes modulate arbovirus in... Read More about The SUMOylation pathway suppresses arbovirus replication in Aedes aegypti cells.

Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8 (2020)
Journal Article

Bluetongue virus (BTV) causes an economically important disease, bluetongue (BT), in susceptible ruminants and is transmitted primarily by species of Culicoides biting midges (Diptera: Ceratopogonidae). Since 2006, northern Europe has experienced mul... Read More about Diversity of Transmission Outcomes Following Co-Infection of Sheep with Strains of Bluetongue Virus Serotype 1 and 8.

Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830) (2020)
Journal Article

Culicoides biting midges (Diptera: Ceratopogonidae) transmit arboviruses of veterinary or medical importance, including bluetongue virus (BTV) and Schmallenberg virus, as well as causing severe irritation to livestock and humans. Arthropod cell lines... Read More about Continuous Cell Lines from the European Biting Midge Culicoides nubeculosus (Meigen, 1830).

“Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence (2020)
Journal Article

© 2020 Pascall et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cr... Read More about “Frozen evolution” of an RNA virus suggests accidental release as a potential cause of arbovirus re-emergence.

Virological, immunological and pathological findings of transplacentally transmitted bluetongue virus serotype 1 in IFNAR1-blocked mice during early and mid gestation (2020)
Journal Article

© 2020, The Author(s). Transplacental transmission (TPT) of wild-type Indian BTV-1 had never been experimentally proved. This study was first time investigated TPT of Indian BTV-1 (isolated from aborted and stillborn goat fetal spleens). The sequenti... Read More about Virological, immunological and pathological findings of transplacentally transmitted bluetongue virus serotype 1 in IFNAR1-blocked mice during early and mid gestation.

Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot (2019)
Journal Article

For segmented viruses, rapid genomic and phenotypic changes can occur through the process of reassortment, whereby co-infecting strains exchange entire segments creating novel progeny virus genotypes. However, for many viruses with segmented genomes,... Read More about Contrasting selective patterns across the segmented genome of bluetongue virus in a global reassortment hotspot.

Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice (2019)
Journal Article

Bluetongue is a severe, economically important disease of ruminants that is widely distributed in tropical and temperate regions around the world. It is associated with major production losses, restrictions of animal movements and trade, as well as c... Read More about Bluetongue virus outer-capsid protein VP2 expressed in Nicotiana Nicotiana benthamiana raises neutralising antibodies and a protective immune response in IFNAR -/- mice.

A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host (2019)
Journal Article

Bluetongue virus (BTV) causes an economically important disease in domestic and wildlife ruminants and is transmitted by Culicoides biting midges. In ruminants, BTV has a wide cell tropism that includes endothelial cells of vascular and lymphatic ves... Read More about A low-passage insect-cell isolate of bluetongue virus uses a macropinocytosis-like entry pathway to infect natural target cells derived from the bovine host.

Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus (2018)
Journal Article

© 2018, Sociedade Brasileira de Microbiologia. Equine encephalosis (EE) is an acute, arthropod-borne, noncontagious, febrile disease of equids. The clinical signs of EE are similar to milder forms of African horse sickness (AHS) and the two diseases... Read More about Quantitative RT-PCR assays for identification and typing of the Equine encephalosis virus.

Bird-biting mosquitoes on farms in southern England (2018)
Journal Article

Comparative neuropathology of major Indian Bluetongue virus serotypes in a neonatal BALB/c mouse model (2018)
Journal Article

Bluetongue virus (BTV) is neurotropic in nature, especially in ruminant fetuses and in-utero infection results in abortion and congenital brain malformations. The aim of the present study was to compare the neuropathogenicity of major Indian BTV sero... Read More about Comparative neuropathology of major Indian Bluetongue virus serotypes in a neonatal BALB/c mouse model.