Image-guided neural activity manipulation with a paramagnetic drug

Bricault, Sarah; Barandov, Ali; Harvey, Peter; DeTienne, Elizabeth; Hai, Aviad; Jasanoff, Alan

doi:10.1038/s41467-019-13933-5

All Outputs (3)

Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates (2020)
Journal Article

Upconverting phosphors (UCPs) convert multiple low energy photons into higher energy emission via the process of photon upconversion and offer an attractive alternative to organic fluorophores for use as luminescent probes. Here, UCPs were capped wit... Read More about Covalent attachment of active enzymes to upconversion phosphors allows ratiometric detection of substrates.

Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems (2020)
Journal Article

Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such... Read More about Pro-organic radical contrast agents (“pro-ORCAs”) for real-time MRI of pro-drug activation in biological systems.

Image-guided neural activity manipulation with a paramagnetic drug (2020)
Journal Article

© 2020, The Author(s). Targeted manipulations of neural activity are essential approaches in neuroscience and neurology, but monitoring such procedures in the living brain remains a significant challenge. Here we introduce a paramagnetic analog of th... Read More about Image-guided neural activity manipulation with a paramagnetic drug.