Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage

Green, Luke R.; Al-Rubaiawi, Ali A.; Al-Maeni, Mohammad A.R.M.; Harrison, Odile B.; Blades, Matthew; Oldfield, Neil J.; Turner, David P.J.; Maiden, Martin C.J.; Bayliss, Christopher D.

doi:10.1128/mBio.03068-19

All Outputs (4)

Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders (2020)
Journal Article

© Copyright © 2020 Holmes, Green, Oldfield, Turner and Bayliss. Rapid transmission, a critical contributory factor in outbreaks of invasive meningococcal disease, requires naïve populations of sufficient size and intermingling. We examined genomic va... Read More about Rapid Transmission of a Hyper-Virulent Meningococcal Clone Due to High Effective Contact Numbers and Super Spreaders.

A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis (2020)
Journal Article

Neisseria meningitidis (the meningococcus) remains an important cause of human disease, including meningitis and sepsis. Adaptation to the host environment includes many interactions with specific cell surface receptors, resulting in intracellular si... Read More about A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis.

Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage (2020)
Journal Article

Host persistence of bacteria is facilitated by mutational and recombina-torial processes that counteract loss of genetic variation during transmission and selection from evolving host responses. Genetic variation was investigated during persistent as... Read More about Localized Hypermutation is the Major Driver of Meningococcal Genetic Variability during Persistent Asymptomatic Carriage.

Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage (2020)
Journal Article

© 2020 Green et al. Host persistence of bacteria is facilitated by mutational and recombina-torial processes that counteract loss of genetic variation during transmission and selection from evolving host responses. Genetic variation was investigated... Read More about Localized hypermutation is the major driver of meningococcal genetic variability during persistent asymptomatic carriage.