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A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis

Azimi, Sheyda; Wheldon, Lee M.; Oldfield, Neil J.; Ala'Aldeen, Dlawer A.A.; Wooldridge, Karl G.

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Authors

Sheyda Azimi

Lee M. Wheldon

Dlawer A.A. Ala'Aldeen



Abstract

Neisseria meningitidis (the meningococcus) remains an important cause of human disease, including meningitis and sepsis. Adaptation to the host environment includes many interactions with specific cell surface receptors, resulting in intracellular signalling and cytoskeletal rearrangements that contribute to pathogenesis. Here, we assessed the interactions between meningococci and Fibroblast Growth Factor Receptor 1-IIIc (FGFR1-IIIc): a receptor specific to endothelial cells of the microvasculature, including that of the blood-brain barrier. We show that the meningococcus recruits FGFR1-IIIc onto the surface of human blood microvascular endothelial cells (HBMECs). Furthermore, we demonstrate that expression of FGFR1-IIIc is required for optimal invasion of HBMECs by meningococci. We show that the ability of N. meningitidis to interact with the ligand-binding domain of FGFR1-IIIc is shared with the other pathogenic Neisseria species, N. gonorrhoeae, but not with commensal bacteria including non-pathogenic Neisseria species.

Citation

Azimi, S., Wheldon, L. M., Oldfield, N. J., Ala'Aldeen, D. A., & Wooldridge, K. G. (2020). A role for fibroblast growth factor receptor 1 in the pathogenesis of Neisseria meningitidis. Microbial Pathogenesis, 149, Article 104534. https://doi.org/10.1016/j.micpath.2020.104534

Journal Article Type Article
Acceptance Date Sep 21, 2020
Online Publication Date Oct 9, 2021
Publication Date Dec 1, 2020
Deposit Date Dec 8, 2021
Publicly Available Date Mar 28, 2024
Journal Microbial Pathogenesis
Print ISSN 0882-4010
Electronic ISSN 1096-1208
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 149
Article Number 104534
DOI https://doi.org/10.1016/j.micpath.2020.104534
Keywords Microbiology; Infectious Diseases
Public URL https://nottingham-repository.worktribe.com/output/4950078
Publisher URL https://www.sciencedirect.com/science/article/abs/pii/S0882401020309001

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