Research Repository

See what's under the surface


High-throughput miniaturized screening of nanoparticle formation via inkjet printing (2018)
Journal Article
Styliari, I. D., Conte, C., Pearce, A. K., Hüsler, A., Cavanagh, R. J., Limo, M. J., …Taresco, V. (in press). High-throughput miniaturized screening of nanoparticle formation via inkjet printing. Macromolecular Materials and Engineering, doi:10.1002/mame.201800146. ISSN 1438-7492

The self‐assembly of specific polymers into well‐defined nanoparticles (NPs) is of great interest to the pharmaceutical industry as the resultant materials can act as drug delivery vehicles. In this work, a high‐throughput method to screen the abilit... Read More

Gate-defined quantum confinement in InSe-based van der Waals heterostructures (2018)
Journal Article
Hamer, M. J., Tovari, E., Zhu, M., Thompson, M., Mayorov, A., Prance, J., …Gorbachev, R. (in press). Gate-defined quantum confinement in InSe-based van der Waals heterostructures. Nano Letters, doi:10.1021/acs.nanolett.8b01376. ISSN 1530-6984

Indium selenide, a post-transition metal chalcogenide, is a novel two-dimensional (2D) semiconductor with interesting electronic properties. Its tunable band gap and high electron mobility have already attracted considerable research interest. Here w... Read More

Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films (2018)
Journal Article
Hüsler, A., Haas, S., Parry, L., Romero, M., Nisisako, T., Williams, P., …Alexander, M. R. (2018). Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films. RSC Advances, 8(28), doi:10.1039/c8ra01491d. ISSN 2046-2069

Micro- and nanoparticles are of great interest because of their potential for trafficking into the body for applications such as low-fouling coatings on medical devices, drug delivery in pharmaceutics and cell carriers in regenerative medicine strate... Read More

Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network (2018)
Journal Article
Scofield, S., Murison, A., Jones, A., Fozard, J., Aida, M., & Band, L. R. (2018). Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network. Development, 145(9), doi:10.1242/dev.157081

The Arabidopsis homeodomain transcription factor SHOOT MERISTEMLESS (STM) is crucial for shoot apical meristem (SAM) function, yet the components and structure of the STMgene regulatory network (GRN) are largely unknown. Here, we show that transcript... Read More

Electrochemically stimulating developments in bioelectronic medicine (2018)
Journal Article
Sanjuan-Alberte, P., Alexander, M. R., Hague, R. J., & Rawson, F. J. (2018). Electrochemically stimulating developments in bioelectronic medicine. Bioelectronic Medicine, 4(1), doi:10.1186/s42234-018-0001-z. ISSN 2332-8886

Cellular homeostasis is in part controlled by biological generated electrical activity. By interfacing biology with electronic devices this electrical activity can be modulated to actuate cellular behaviour. There are current limitations in merging e... Read More

3D extrusion printing of high drug loading immediate release paracetamol tablets (2018)
Journal Article
Khaled, S. A., Alexander, M. R., Wildman, R. D., Wallace, M. J., Sharpe, S., Yoo, J., & Roberts, C. J. (2018). 3D extrusion printing of high drug loading immediate release paracetamol tablets. International Journal of Pharmaceutics, 538(1-2), doi:10.1016/j.ijpharm.2018.01.024. ISSN 0378-5173

The manufacture of immediate release high drug loading paracetamol oral tablets was achieved using an extrusion based 3D printer from a premixed water based paste formulation. The 3D printed tablets demonstrate that a very high drug (paracetamol) loa... Read More

Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells (2017)
Journal Article
Vining, K. H., Scherba, J. C., Bever, A., Alexander, M. R., Celiz, A. D., & Mooney, D. J. (2018). Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells. Advanced Materials, 30(4), doi:10.1002/adma.201704486. ISSN 0935-9648

Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstruct... Read More

Prediction of broad-spectrum pathogen attachment to coating materials for biomedical devices (2017)
Journal Article
Mikulskis, P., Hook, A., Dundas, A., Irvine, D. J., Sanni, O., Anderson, D., …Winkler, D. A. (in press). Prediction of broad-spectrum pathogen attachment to coating materials for biomedical devices. ACS Applied Materials and Interfaces, 10(1), doi:10.1021/acsami.7b14197. ISSN 1944-8244

Bacterial infections in healthcare settings are a frequent accompaniment to both routine procedures such as catheterization and surgical site interventions. Their impact is becoming even more marked as the numbers of medical devices that are used to... Read More

The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power (2017)
Journal Article
Passarelli, M. K., Pirkl, A., Moellers, R., Grinfeld, D., Kollmer, F., Havelund, R., …Gilmore, I. S. (in press). The 3D OrbiSIMS—label-free metabolic imaging with subcellular lateral resolution and high mass-resolving power. Nature Methods, doi:10.1038/NMETH.4504. ISSN 1548-7091

We report the development of a 3D OrbiSIMS instrument for label-free biomedical imaging. It combines the high spatial resolution of secondary ion mass spectrometry (SIMS; under 200 nm for inorganic species and under 2 μm for biomolecules) with the hi... Read More

Water contact angle is not a good predictor of biological responses to materials (2017)
Journal Article
Alexander, M. R., & Williams, P. (in press). Water contact angle is not a good predictor of biological responses to materials. Biointerphases, 12(2), doi:10.1116/1.4989843. ISSN 1934-8630

Often the view is expressed that water contact angle (WCA) or other wettability/surface energy measurements made on a material surface can be used to predict cellular attachment to materials, e.g., bacteria attach to hydrophobic surfaces. In this art... Read More

Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction (2017)
Journal Article
Pearce, A. K., Travanut, A., Couturaud, B., Taresco, V., Howdle, S. M., Alexander, M. R., & Alexander, C. (2017). Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction. ACS Macro Letters, 6(7), doi:10.1021/acsmacrolett.7b00415. ISSN 2161-1653

The widespread adoption of RAFT polymerization stems partly from the ease and utility of installing a functional chain transfer agent onto the ends of the generated polymer chains. In parallel, the Passerini multicomponent reaction offers great versa... Read More

3D printing of tablets using inkjet with UV photoinitiation (2017)
Journal Article
Clark, E. A., Alexander, M. R., Irvine, D. J., Roberts, C. J., Wallace, M. J., Sharpe, S., …Wildman, R. D. (in press). 3D printing of tablets using inkjet with UV photoinitiation. International Journal of Pharmaceutics, doi:10.1016/j.ijpharm.2017.06.085. ISSN 0378-5173

Additive manufacturing (AM) offers significant potential benefits in the field of drug delivery and pharmaceutical/medical device manufacture. Of AM processes, 3D inkjet printing enables precise deposition of a formulation, whilst offering the potent... Read More

Image based machine learning for identification of macrophage subsets (2017)
Journal Article
Rostam, H., Reynolds, P. M., Alexander, M. R., Gadegaard, N., & Ghaemmaghami, A. M. (in press). Image based machine learning for identification of macrophage subsets. Scientific Reports, 7, doi:10.1038/s41598-017-03780-z. ISSN 2045-2322

Macrophages play a crucial rule in orchestrating immune responses against pathogens and foreign materials. Macrophages have remarkable plasticity in response to environmental cues and are able to acquire a spectrum of activation status, best exemplif... Read More