Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates

Contreas, Leonardo; Hook, Andrew L.; Winkler, David A.; Figueredo, Grazziela; Williams, Paul; Laughton, Charles A.; Alexander, Morgan R.; Williams, Philip M.

Abstract

Bacterial infections are increasingly problematic due to the rise of antimicrobial resistance. Consequently, the rational design of materials naturally resistant to biofilm formation is an important strategy for preventing medical device-associated infections. Machine learning (ML) is a powerful method to find useful patterns in complex data from a wide range of fields. Recent reports showed how ML can reveal strong relationships between bacterial adhesion and the physicochemical properties of polyacrylate libraries. These studies used robust and predictive nonlinear regression methods that had better quantitative prediction power than linear models. However, as nonlinear models’ feature importance is a local rather than global property, these models were hard to interpret and provided limited insight into the molecular details of material-bacteria interactions. Here, we show that the use of interpretable mass spectral molecular ions and chemoinformatic descriptors and a linear binary classification model of attachment of three common nosocomial pathogens to a library of polyacrylates can provide improved guidance for the design of more effective pathogen-resistant coatings. Relevant features from each model were analyzed and correlated with easily interpretable chemoinformatic descriptors to derive a small set of rules that give model features tangible meaning that elucidate relationships between the structure and function. The results show that the attachment of Pseudomonas aeruginosa and Staphylococcus aureus can be robustly predicted by chemoinformatic descriptors, suggesting that the obtained models can predict the attachment response to polyacrylates to identify anti-attachment materials to synthesize and test in the future.

Citation

Contreas, L., Hook, A. L., Winkler, D. A., Figueredo, G., Williams, P., Laughton, C. A., Alexander, M. R., & Williams, P. M. (2023). Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates. ACS Applied Materials and Interfaces, 15(11), 14155-14163. https://doi.org/10.1021/acsami.2c23182

• Journal Article Type: Article
• Acceptance Date: Feb 23, 2023
• Online Publication Date: Mar 7, 2023
• Publication Date: Mar 22, 2023
• Deposit Date: Mar 8, 2023
• Publicly Available Date: Mar 10, 2023
• Journal: ACS Applied Materials and Interfaces
• Print ISSN: 1944-8244
• Electronic ISSN: 1944-8252
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• Volume: 15
• Issue: 11
• Pages: 14155-14163
• DOI: https://doi.org/10.1021/acsami.2c23182
• Keywords: Bacteria, Infectious diseases, Ions, Molecular modeling, Polymers
• Public URL: https://nottingham-repository.worktribe.com/output/18229486
• Publisher URL: https://pubs.acs.org/doi/10.1021/acsami.2c23182