All Outputs (13)

ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana (2023)
Journal Article

Oxygen is a key signalling component of plant biology, and whilst an oxygen-sensing mechanism was previously described in Arabidopsis thaliana, key features of the associated PLANT CYSTEINE OXIDASE (PCO) N-degron pathway and Group VII ETHYLENE RESPON... Read More about ERFVII action and modulation through oxygen-sensing in Arabidopsis thaliana.

A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance (2023)
Journal Article

Increasing drought phenomena pose a serious threat to agricultural productivity. Although plants have multiple ways to respond to the complexity of drought stress, the underlying mechanisms of stress sensing and signaling remain unclear. The role of... Read More about A phloem‐localized Arabidopsis metacaspase (AtMC3) improves drought tolerance.

An oxygen-sensing mechanism for angiosperm adaptation to altitude (2022)
Journal Article

Flowering plants (angiosperms) can grow at extreme altitudes, and have been observed growing as high as 6,400 metres above sea level1,2; however, the molecular mechanisms that enable plant adaptation specifically to altitude are unknown. One distingu... Read More about An oxygen-sensing mechanism for angiosperm adaptation to altitude.

Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway (2022)
Journal Article

Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions including uncoupled respiration... Read More about Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway.

A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions (2022)
Journal Article

The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating enzyme 2 (AtUBC2) from Arabi... Read More about A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions.

The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development (2020)
Journal Article

© 2020 The Authors. New Phytologist © 2020 New Phytologist Trust VERNALIZATION2 (VRN2), an angiosperm-specific subunit of the polycomb repressive complex 2 (PRC2), is an oxygen (O2)-regulated target of the PCO branch of the PRT6 N-degron pathway of u... Read More about The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.

Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment (2018)
Journal Article

The Arg/N-end rule pathway of ubiquitin-mediated proteolysis has multiple functions throughout plant development, notably in the transition from dormant seed to photoautotrophic seedling. PROTEOLYSIS6 (PRT6), an N-recognin E3 ligase of the Arg/N-end... Read More about Genetic interactions between ABA signalling and the Arg/N-end rule pathway during Arabidopsis seedling establishment.

Distinct branches of the N‐end rule pathway modulate the plant immune response (2018)
Journal Article

© 2018 The Authors. New Phytologist © 2018 New Phytologist Trust The N-end rule pathway is a highly conserved constituent of the ubiquitin proteasome system, yet little is known about its biological roles. Here we explored the role of the N-end rule... Read More about Distinct branches of the N‐end rule pathway modulate the plant immune response.

Sumoylation and phosphorylation: hidden and overt links (2018)
Journal Article

Post-translational modifications are essential mediators between stimuli from development or the environment and adaptive transcriptional patterns. Recent data allow a first glimpse at how two modifications, phosphorylation and sumoylation, act inter... Read More about Sumoylation and phosphorylation: hidden and overt links.

Finite indentation of highly curved elastic shells (2018)
Journal Article

Experimentally measuring the elastic properties of thin biological surfaces is non-trivial, particularly when they are curved. One technique that may be used is the indentation of a thin sheet of material by a rigid indenter, whilst measuring the app... Read More about Finite indentation of highly curved elastic shells.

N-term 2017: Proteostasis via the N-terminus (2017)
Journal Article

N-term 2017 was the first international meeting to bring together researchers from diverse disciplines with a shared interest in protein N-terminal modifications and the N-end rule pathway of ubiquitin-mediated proteolysis, providing a platform for i... Read More about N-term 2017: Proteostasis via the N-terminus.

From start to finish: amino-terminal protein modifications as degradation signals in plants (2016)
Journal Article

The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated... Read More about From start to finish: amino-terminal protein modifications as degradation signals in plants.

The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm (2016)
Journal Article

The precocious germination of cereal grains before harvest, also known as pre-harvest sprouting, is an important source of yield and quality loss in cereal production. Pre-harvest sprouting is a complex grain defect and is becoming an increasing chal... Read More about The wheat Phs-A1 pre-harvest sprouting resistance locus delays the rate of seed dormancy loss and maps 0.3 cM distal to the PM19 genes in UK germplasm.