Daniel J. Gibbs
From start to finish: amino-terminal protein modifications as degradation signals in plants
Gibbs, Daniel J.; Bailey, Mark; Tedds, Hannah M.; Holdsworth, Michael J.
Authors
Mark Bailey
Hannah M. Tedds
Professor MICHAEL HOLDSWORTH michael.holdsworth@nottingham.ac.uk
Professor of Crop Science
Abstract
The amino- (N-) terminus (Nt) of a protein can undergo a diverse array of co- and posttranslational modifications. Many of these create degradation signals (N-degrons) that mediate protein destruction via the N-end rule pathway of ubiquitin-mediated proteolysis. In plants, the N-end rule pathway has emerged as a major system for regulated control of protein stability. Nt-arginylation-dependent degradation regulates multiple growth, development and stress responses, and recently identified functions of Nt-acetylation can also be linked to effects on the in vivo half-lives of Nt-acetylated proteins. There is also increasing evidence that N-termini could act as important protein stability determinants in plastids. Here we review recent advances in our understanding of the relationship between the nature of protein N-termini, Nt-processing events and proteolysis in plants.
Citation
Gibbs, D. J., Bailey, M., Tedds, H. M., & Holdsworth, M. J. (2016). From start to finish: amino-terminal protein modifications as degradation signals in plants. New Phytologist, 211(4), 1188-1194. https://doi.org/10.1111/nph.14105
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 7, 2016 |
Online Publication Date | Jul 21, 2016 |
Publication Date | Sep 1, 2016 |
Deposit Date | Nov 25, 2016 |
Publicly Available Date | Mar 29, 2024 |
Journal | New Phytologist |
Print ISSN | 0028-646X |
Electronic ISSN | 1469-8137 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 211 |
Issue | 4 |
Pages | 1188-1194 |
DOI | https://doi.org/10.1111/nph.14105 |
Keywords | N-terminus, proteolysis, N-end rule, N-degron, protein modification, Nt-12 acetylation, protease, ubiquitin proteasome system |
Public URL | https://nottingham-repository.worktribe.com/output/800005 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1111/nph.14105/full |
Additional Information | This is the peer reviewed version of the following article: Gibbs, D. J., Bailey, M., Tedds, H. M. and Holdsworth, M. J. (2016), From start to finish: amino-terminal protein modifications as degradation signals in plants. New Phytologist, 211: 1188–1194., which has been published in final form at http://dx.doi.org/10.1111/nph.14105. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
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