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All Outputs (72)

In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal (2020)
Journal Article
Maruca, A., Lupia, A., Rocca, R., Keszthelyi, D., Corsetti, M., & Alcaro, S. (2020). In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal. International Journal of Molecular Sciences, 21(23), Article 9127. https://doi.org/10.3390/ijms21239127

Food-drug interaction is an infrequently considered aspect in clinical practice. Usually, drugs are taken together with meals and what follows may adversely affect pharmacokinetic and pharmacodynamic properties, and hence, the therapeutic effects. In... Read More about In Silico Food-Drug Interaction: A Case Study of Eluxadoline and Fatty Meal.

Irritable Bowel Syndrome (2020)
Journal Article
Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020). Irritable Bowel Syndrome. Lancet, 396(10263), 1675-1688. https://doi.org/10.1016/S0140-6736%2820%2931548-8

Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder whose symptoms include abdominal pain associated with a change in stool form or frequency. The condition affects between 5% and 10% of otherwise healthy individuals in the commu... Read More about Irritable Bowel Syndrome.

Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test? (2020)
Journal Article
Basilisco, B., & Corsetti, M. (2020). Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test?. Neurogastroenterology and Motility, 32(10), Article e14001. https://doi.org/10.1111/nmo.14001

Symptoms such as a feeling of incomplete evacuation, straining, absence of the call to stool, anal blockage or digitation suggest the presence a functional defecation disorder. As symptoms do not distinguish between patients with and without function... Read More about Seated anorectal manometry during simulated evacuation. A physiological exercise or a new clinically useful diagnostic test?.

Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications (2020)
Journal Article
Augustijns, P., Vertzoni, M., Reppas, C., Langguth, P., Lennernäs, H., Abrahamsson, B., …Hens, B. (2020). Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications. European Journal of Pharmaceutical Sciences, 155, Article 105517. https://doi.org/10.1016/j.ejps.2020.105517

Fluid sampling from the gastrointestinal (GI) tract has been applied as a valuable tool to gain more insight into the fluids present in the human GI tract and to explore the dynamic interplay of drug release, dissolution, precipitation and absorption... Read More about Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications.

The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge (2020)
Journal Article
Wilkinson-Smith, V., Menys, A., Bradley, C., Corsetti, M., Marciani, L., Atkinson, D., …Hoad, C. (2020). The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge. Neurogastroenterology and Motility, 32(11), Article e13942. https://doi.org/10.1111/nmo.13942

Background

Magnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intra-subject reproducibility of MRI measures of colonic funct... Read More about The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.

Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study (2020)
Journal Article
Vork, L., Keszthelyi, D., van Kuijk, S. M., Quetglas, E. G., Törnblom, H., Simrén, M., …Masclee, A. A. (2020). Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study. Clinical and Translational Gastroenterology, 11(7), Article e00209. https://doi.org/10.14309/ctg.0000000000000209

INTRODUCTION:

Gastrointestinal symptoms in irritable bowel syndrome (IBS) have been correlated with psychological factors using retrospective symptom assessment. However, real-time symptom assessment might reveal the interplay between abdominal a... Read More about Patient-Specific Stress–Abdominal Pain Interaction in Irritable Bowel Syndrome: An Exploratory Experience Sampling Method Study.

Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism (2020)
Journal Article
Dent, J., Dinning, P., Corsetti, M., Rommel, N., Tack, J., Wiklendt, L., …Deloose, E. (2020). Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism. Neurogastroenterology and Motility, 32(10), Article e13835. https://doi.org/10.1111/nmo.13835

© 2020 John Wiley & Sons Ltd Background: High-resolution manometric studies below the stomach are rare due to technical limitations of traditional manometry catheters. Consequently, specific motor patterns and their impact on gastric and small bowe... Read More about Manometric demonstration of duodenal/jejunal motor function consistent with the duodenal brake mechanism.

Investigation of colonic motility (2019)
Book Chapter
CORSETTI, M., & GUNN, D. (2019). Investigation of colonic motility. In S. Rao, Y. Lee, & U. Ghosal (Eds.), Clinical and Basic Neurogastroenterology and Motility. Elsevier

How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery) (2019)
Journal Article
Pauwels, A., Boecxstaens, V., Andrews, C., Attwood, S. E., Berrisford, R., Bisschops, R., …Tack, J. F. (2019). How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery). Gut, 68(11), 1928-1941. https://doi.org/10.1136/gutjnl-2019-318260

Objective: Anti-reflux surgery can be proposed in patients with gastro-esophageal reflux disease, especially when proton pump inhibitor use leads to incomplete symptom improvement. However, to date, international consensus guidelines on the clinical... Read More about How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery).

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques (2019)
Journal Article
Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P., …Tack, J. (2019). First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nature Reviews Gastroenterology and Hepatology, 16(9), 559-579. https://doi.org/10.1038/s41575-019-0167-1

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminol... Read More about First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.

“Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy (2019)
Journal Article
Hens, B., Corsetti, M., Bermejo, M., Löbenberg, R., González, P. M., Mitra, A., …Aceituno, A. (2019). “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy. AAPS Journal, 21(4), 1-16. https://doi.org/10.1208/s12248-019-0346-6

The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature pose... Read More about “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy.

Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers (2019)
Journal Article
Zhao, D., Corsetti, M., Moeini-Jazani, M., Weltens, N., Tuk, M., Tack, J., …Van Oudenhove, L. (2019). Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers. Neurogastroenterology and Motility, 31(7), Article e13600. https://doi.org/10.1111/nmo.13600

Background: Past research has demonstrated that moderate urge to urinate improves inhibitory control, specifically among participants with higher behavioral inhibition sensitivity (BIS). The effect was absent when the urge exceeded intolerable level.... Read More about Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers.

The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group (2019)
Journal Article
Koziolek, M., Alcaro, S., Augustijns, P., Basit, A. W., Grimm, M., Hens, B., …Corsetti, M. (2019). The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group. European Journal of Pharmaceutical Sciences, 134, 31-59. https://doi.org/10.1016/j.ejps.2019.04.003

The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of th... Read More about The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group.

Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders? (2019)
Journal Article
Corsetti, M., Pannemans, J., & Whorwell, P. (2019). Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research, 8, Article 257. https://doi.org/10.12688/f1000research.15974.1

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term bas... Read More about Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?.

Prevalence and impact of self-reported irritable bowel symptoms in the general population (2018)
Journal Article
Van den Houte, K., Carbone, F., Pannemans, J., Corsetti, M., Fischler, B., Piessevaux, H., & Tack, J. (2019). Prevalence and impact of self-reported irritable bowel symptoms in the general population. United European Gastroenterology Journal, 7(2), 307-315. https://doi.org/10.1177/2050640618821804

Background and aims
The symptom-based diagnostic criteria for irritable bowel syndrome (IBS) have recently been revised in the Rome IV consensus. On the other hand, with rising public awareness of IBS, self-diagnosis and self-management is also incr... Read More about Prevalence and impact of self-reported irritable bowel symptoms in the general population.

Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI? (2018)
Journal Article
Hoad, C., Clarke, C., Marciani, L., Graves, M. J., & Corsetti, M. (2018). Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI?. British Journal of Radiology, 92(1093), https://doi.org/10.1259/bjr.20180433

Cine cardiac MRI is generally accepted as the “gold-standard” for functional myocardial assessment. It only took a few years after the development of commercial MRI systems for functional cardiac imaging to be developed, with electrocardiogram (ECG)-... Read More about Will MRI of gastrointestinal function parallel the clinical success of cine cardiac MRI?.

Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders? (2018)
Journal Article
Pannemans, J., & Corsetti, M. (2018). Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?. Current Opinion in Pharmacology, 43, 53-58. https://doi.org/10.1016/j.coph.2018.08.008

Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on... Read More about Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?.

Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome (2018)
Journal Article
Barbara, G., Grover, M., Bercik, P., Corsetti, M., Ghoshal, U. C., Ohman, L., & Rajilić-Stojanović, M. (2019). Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome. Gastroenterology, 156(1), 46-58.e7. https://doi.org/10.1053/j.gastro.2018.07.011

Background & Aims: The existence of postinfection irritable bowel syndrome (PI-IBS) has been substantiated by epidemiology studies conducted in diverse geographic and clinical settings. However, the available evidence has not been well summarized, an... Read More about Rome Foundation Working Team Report on Post-Infection Irritable Bowel Syndrome.