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First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques

Corsetti, Maura; Costa, Marcello; Bassotti, Gabrio; Bharucha, Adil E.; Borrelli, Osvaldo; Dinning, Phil; Lorenzo, Carlo Di; Huizinga, Jan D.; Jimenez, Marcel; Rao, Satish; Spiller, Robin; Spencer, Nick J; Lentle, Roger; Pannemans, Jasper; Thys, Alexander; Benninga, Marc; Tack, Jan


Marcello Costa

Gabrio Bassotti

Adil E. Bharucha

Osvaldo Borrelli

Phil Dinning

Carlo Di Lorenzo

Jan D. Huizinga

Marcel Jimenez

Satish Rao

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Professor of Gastroenterology

Nick J Spencer

Roger Lentle

Jasper Pannemans

Alexander Thys

Marc Benninga

Jan Tack


Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminologies and definitions have been used to describe colonic motor patterns in children, adults and animals. An example is the distinction between the high-amplitude propagating contractions in humans and giant contractions in animals. Harmonized terminology and definitions are required that are applicable to the study of colonic motility performed by basic scientists and clinicians, as well as adult and paediatric gastroenterologists. As clinical studies increasingly require adequate animal models to develop and test new therapies, there is a need for rational use of terminology to describe those motor patterns that are equivalent between animals and humans. This Consensus Statement provides the first harmonized interpretation of commonly used terminology to describe colonic motor function and delineates possible similarities between motor patterns observed in animal models and humans in vitro (ex vivo) and in vivo. The consolidated terminology can be an impetus for new research that will considerably improve our understanding of colonic motor function and will facilitate the development and testing of new therapies for colonic motility disorders.


Corsetti, M., Costa, M., Bassotti, G., Bharucha, A. E., Borrelli, O., Dinning, P., …Tack, J. (2019). First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nature Reviews Gastroenterology and Hepatology, 16(9), 559-579.

Journal Article Type Article
Acceptance Date May 31, 2019
Online Publication Date Jul 11, 2019
Publication Date Jul 11, 2019
Deposit Date Jun 13, 2019
Publicly Available Date Jul 15, 2019
Journal Nature Reviews Gastroenterology & Hepatology
Print ISSN 1759-5045
Electronic ISSN 1759-5053
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 16
Issue 9
Pages 559-579
Keywords Hepatology; Gastroenterology
Public URL
Publisher URL
Additional Information Accepted: 30 May 2019; First Online: 11 July 2019; : The authors declare no competing interests.


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