Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?

Corsetti, Maura; Pannemans, Jasper; Whorwell, Peter

Abstract

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term basis. Moreover, they are known to induce paradoxical hyperalgesia as well as alterations of gut function. The analgesic properties of opioids are mediated by receptors located in the brain, but as opioid receptors are also expressed in the gastrointestinal tract, new drugs acting on these receptors have recently been developed to treat two functional disorders, namely irritable bowel syndrome with diarrhoea and opioid-induced constipation. The aim of this article is to highlight some interesting observations resulting from the development of these drugs in the field of functional gastrointestinal disorders.

Citation

Corsetti, M., Pannemans, J., & Whorwell, P. (2019). Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?. F1000Research, 8, Article 257. https://doi.org/10.12688/f1000research.15974.1

• Journal Article Type: Article
• Acceptance Date: Mar 5, 2019
• Online Publication Date: Mar 5, 2019
• Publication Date: Mar 5, 2019
• Deposit Date: Mar 15, 2019
• Publicly Available Date: Mar 18, 2019
• Journal: F1000Research
• Electronic ISSN: 2046-1402
• Publisher: F1000Research
• Peer Reviewed: Peer Reviewed
• Volume: 8
• Article Number: 257
• DOI: https://doi.org/10.12688/f1000research.15974.1
• Keywords: Opioids; Mu opioid receptors; PAMORA; Eluxadoline
• Public URL: https://nottingham-repository.worktribe.com/output/1657899
• Publisher URL: https://f1000research.com/articles/8-257/v1
• Additional Information: Referee status: Indexed; Referee Report: 10.5256/f1000research.17446.r44837, Klaus Bielefeldt, Gastroenterology Section, George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, UT, USA, 05 Mar 2019, version 1, indexed; Referee Report: 10.5256/f1000research.17446.r44836, Eamonn Quigley, Houston Methodist Hospital, Houston, TX, USA, 05 Mar 2019, version 1, indexed; Grant Information: The author(s) declared that no grants were involved in supporting this work; Copyright: This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication).
• Contract Date: Mar 18, 2019