Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?

Pannemans, J.; Corsetti, M.

Abstract

Opioids have been used for centuries, mostly as a sedative and to treat pain. Currently, they are used on a global scale for the treatment of acute and chronic pain in diseases as osteoarthritis, fibromyalgia, and low back pain. Binding of opioids on opioid receptors can cause a range of different effects such as changes in stress response, analgesia, motor activity and autonomic functions. This review provide a synthetic summary of the most recent literature on the use of drugs acting on mu-receptors to treat two prevalent functional bowel disorders, presenting with opposite bowel habit. Eluxadoline and naloxegol, methylnaltrexone and naldemedine are recently FDA and/or EMA approved drugs demonstrated to be effective and safe for treatment respectively of irritable bowel syndrome subtype diarrhea and opioid induced constipation.

Citation

Pannemans, J., & Corsetti, M. (2018). Opioid receptors in the GI tract: targets for treatment of both diarrhea and constipation in functional bowel disorders?. Current Opinion in Pharmacology, 43, 53-58. doi:10.1016/j.coph.2018.08.008

• Journal Article Type: Article
• Acceptance Date: Sep 3, 2018
• Online Publication Date: Sep 3, 2018
• Publication Date: 2018-12
• Deposit Date: Dec 21, 2018
• Journal: Current Opinion in Pharmacology
• Print ISSN: 1471-4892
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 43
• Pages: 53-58
• DOI: https://doi.org/10.1016/j.coph.2018.08.008
• Keywords: Pharmacology; Drug Discovery
• Public URL: https://nottingham-repository.worktribe.com/output/1438410
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S1471489218300146?via%3Dihub