Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?

Corsetti, Maura; Pannemans, Jasper; Whorwell, Peter

doi:10.12688/f1000research.15974.1

All Outputs (9)

Treatment of Irritable Bowel Syndrome with diarrhoea using Titrated Ondansetron (TRITON): study protocol for a randomised control trial (2019)
Journal Article

Background – Irritable bowel syndrome with diarrhoea (IBS-D) affects up to 4% of the general population. Symptoms include frequent, loose, or watery stools with associated urgency, resulting in marked reduction of quality of life and loss of work pro... Read More about Treatment of Irritable Bowel Syndrome with diarrhoea using Titrated Ondansetron (TRITON): study protocol for a randomised control trial.

How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery) (2019)
Journal Article

Objective: Anti-reflux surgery can be proposed in patients with gastro-esophageal reflux disease, especially when proton pump inhibitor use leads to incomplete symptom improvement. However, to date, international consensus guidelines on the clinical... Read More about How to select patients for anti-reflux surgery? The ICARUS guidelines (International Consensus regarding preoperative examinations and clinical characteristics assessment to select adult patients for AntiReflUx Surgery).

First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques (2019)
Journal Article

Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has revealed that our knowledge of normal motor patterns is limited. Furthermore, various terminol... Read More about First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques.

Letter: limitations of defecography among patients with refractory constipation (2019)
Journal Article

Rectal area as surrogate measure of rectal emptying during MR defecography (2019)
Journal Article

“Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy (2019)
Journal Article

The gastrointestinal (GI) tract is one of the most popular and used routes of drug product administration due to the convenience for better patient compliance and reduced costs to the patient compared to other routes. However, its complex nature pose... Read More about “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy.

Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers (2019)
Journal Article

Background: Past research has demonstrated that moderate urge to urinate improves inhibitory control, specifically among participants with higher behavioral inhibition sensitivity (BIS). The effect was absent when the urge exceeded intolerable level.... Read More about Defecatory urge increases cognitive control and intertemporal patience in healthy volunteers.

The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group (2019)
Journal Article

The simultaneous intake of food and drugs can have a strong impact on drug release, absorption, distribution, metabolism and/or elimination and consequently, on the efficacy and safety of pharmacotherapy. As such, food-drug interactions are one of th... Read More about The mechanisms of pharmacokinetic food-drug interactions: A perspective from the UNGAP group.

Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders? (2019)
Journal Article

Opioids have recently received much attention because of the epidemic in their use in some countries such as the USA and the UK. Concerns have been raised about the possibility that they can increase mortality in patients when used on a long-term bas... Read More about Targeting mu opioid receptors to modulate gastrointestinal function: what have we learnt so far from the studies in functional bowel disorders?.