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A tool for functional brain imaging with lifespan compliance (2019)
Journal Article
Hill, R. M., Boto, E., Holmes, N., Hartley, C., Seedat, Z. A., Leggett, J., …Brookes, M. J. (2019). A tool for functional brain imaging with lifespan compliance. Nature Communications, 10, https://doi.org/10.1038/s41467-019-12486-x

The human brain undergoes significant functional and structural changes in the first decades of life, as the foundations for human cognition are laid down. However, non-invasive imaging techniques to investigate brain function throughout neurodevelop... Read More about A tool for functional brain imaging with lifespan compliance.

Post-stimulus beta responses are modulated by task duration (2019)
Journal Article
Woolrich, M. W., Pakenham, D. O., Quinn, A. J., Fry, A., Francis, S. T., Woolrich, M. W., …Mullinger, K. J. (2020). Post-stimulus beta responses are modulated by task duration. NeuroImage, 206, https://doi.org/10.1016/j.neuroimage.2019.116288

Modulation of beta-band neural oscillations during and following movement is a robust marker of brain function. In particular, the post-movement beta rebound (PMBR), which occurs on movement cessation, has been related to inhibition and connectivity... Read More about Post-stimulus beta responses are modulated by task duration.

Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography (2019)
Journal Article
Holmes, N., Tierney, T. M., Leggett, J., Boto, E., Mellor, S., Roberts, G., …Bowtell, R. (2019). Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography. Scientific Reports, 9, https://doi.org/10.1038/s41598-019-50697-w

To allow wearable magnetoencephalography (MEG) recordings to be made on unconstrained subjects the spatially inhomogeneous remnant magnetic field inside the magnetically shielded room (MSR) must be nulled. Previously, a large bi-planar coil system wh... Read More about Balanced, bi-planar magnetic field and field gradient coils for field compensation in wearable magnetoencephalography.

How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity? (2019)
Journal Article
Liuzzi, L., Quinn, A. J., O'Neill, G. C., Woolrich, M. W., Brookes, M. J., Hillebrand, A., & Tewarie, P. (2019). How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?. Frontiers in Neuroscience, 13, https://doi.org/10.3389/fnins.2019.00797

Despite advances in the field of dynamic connectivity, fixed sliding window approaches for the detection of fluctuations in functional connectivity are still widely used. The use of conventional connectivity metrics in conjunction with a fixed slidin... Read More about How Sensitive Are Conventional MEG Functional Connectivity Metrics With Sliding Windows to Detect Genuine Fluctuations in Dynamic Functional Connectivity?.

Two spatially distinct posterior alpha sources fulfill different functional roles in attention (2019)
Journal Article
Sokoliuk, R., Mayhew, S., Aquino, K., Wilson, R., Brookes, M., Francis, S., …Mullinger, K. (2019). Two spatially distinct posterior alpha sources fulfill different functional roles in attention. Journal of Neuroscience, 39(36), 7183-7194. https://doi.org/10.1523/jneurosci.1993-18.2019

Directing attention helps extracting relevant information and suppressing distracters. Alpha brain oscillations (8-12Hz) are crucial for this process, with power decreases facilitating processing of important information and power increases inhibitin... Read More about Two spatially distinct posterior alpha sources fulfill different functional roles in attention.

Data‐driven model optimization for optically pumped magnetometer sensor arrays (2019)
Journal Article
Duque‐Muñoz, L., Tierney, T. M., Meyer, S. S., Boto, E., Holmes, N., Roberts, G., …Barnes, G. R. (2019). Data‐driven model optimization for optically pumped magnetometer sensor arrays. Human Brain Mapping, 40(15), 4357-4369. https://doi.org/10.1002/hbm.24707

© 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc. Optically pumped magnetometers (OPMs) have reached sensitivity levels that make them viable portable alternatives to traditional superconducting technology for magnetoenceph... Read More about Data‐driven model optimization for optically pumped magnetometer sensor arrays.

Towards OPM-MEG in a virtual reality environment (2019)
Journal Article
Roberts, G., Holmes, N., Alexander, N., Boto, E., Leggett, J., Hill, R. M., …Brookes, M. J. (2019). Towards OPM-MEG in a virtual reality environment. NeuroImage, 199, 408-417. doi:10.1016/j.neuroimage.2019.06.010

Virtual reality (VR) provides an immersive environment in which a participant can experience a feeling of presence in a virtual world. Such environments generate strong emotional and physical responses and have been used for wide-ranging applications... Read More about Towards OPM-MEG in a virtual reality environment.

Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography (2019)
Journal Article
Tierney, T. M., Holmes, N., Mellor, S., López, J. D., Roberts, G., Hill, R. M., …Barnes, G. R. (2019). Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography. NeuroImage, 199, 598-608. doi:10.1016/j.neuroimage.2019.05.063

Optically Pumped Magnetometers (OPMs) have emerged as a viable and wearable alternative to cryogenic, superconducting MEG systems. This new generation of sensors has the advantage of not requiring cryogenic cooling and as a result can be flexibly pla... Read More about Optically pumped magnetometers: From quantum origins to multi-channel magnetoencephalography.

Imaging human cortical responses to intraneural microstimulation using magnetoencephalography (2019)
Journal Article
O'Neill, G. C., Watkins, R. H., Ackerley, R., Barratt, E. L., Sengupta, A., Asghar, M., …Francis, S. T. (2019). Imaging human cortical responses to intraneural microstimulation using magnetoencephalography. NeuroImage, 189, 329-340. doi:10.1016/j.neuroimage.2019.01.017

The sensation of touch in the glabrous skin of the human hand is conveyed by thousands of fast-conducting mechanoreceptive afferents, which can be categorised into four distinct types. The spiking properties of these afferents in the periphery in re... Read More about Imaging human cortical responses to intraneural microstimulation using magnetoencephalography.

Updating dynamic noise models with moving magnetoencephalographic (MEG) systems (2019)
Journal Article
Lopez, J. D., Tierney, T. M., Sucerquia, A., Valencia, F., Holmes, N., Mellor, S., …Barnes, G. R. (2019). Updating dynamic noise models with moving magnetoencephalographic (MEG) systems. IEEE Access, 7(1), 10093-10102. doi:10.1109/access.2019.2891162

Optically pumped magnetometers have opened many possibilities for the study of human brain function using wearable moveable technology. In order to fully exploit this capability, a stable low-field environment at the sensors is required. One way to a... Read More about Updating dynamic noise models with moving magnetoencephalographic (MEG) systems.

Development of human electrophysiological brain networks (2018)
Journal Article
Briley, P. M., Liddle, E. B., Groom, M. J., Smith, H. J. F., Morris, P. G., Colclough, G. L., …Liddle, P. F. (2018). Development of human electrophysiological brain networks. Journal of Neurophysiology, 120(6), 3122-3130. doi:10.1152/jn.00293.2018

Functional activity in the human brain is intrinsically organized into independently active, connected brain regions. These networks include sensorimotor systems, as well as higher-order cognitive networks such as the default mode network (DMN), whic... Read More about Development of human electrophysiological brain networks.

How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes (2018)
Journal Article
Tewarie, P., Abeysuriya, R., Byrne, Á., O'Neill, G. C., Sotioropoulos, S. N., Brookes, M. J., & Coombes, S. (2019). How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes. NeuroImage, 186, 211-220. doi:10.1016/j.neuroimage.2018.10.079

Functional networks obtained from magnetoencephalography (MEG) from different frequency bands show distinct spatial patterns. It remains to be elucidated how distinct spatial patterns in MEG networks emerge given a single underlying structural networ... Read More about How do spatially distinct frequency specific MEG networks emerge from one underlying structural connectome? The role of the structural eigenmodes.

Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit (2018)
Journal Article
Siau, K., Hodson, J., Ingram, R., Baxter, A., Widlak, M. M., Sharratt, C., …Major, G. (2018). Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit. United European Gastroenterology Journal, doi:10.1177/2050640618811491

Background: Endoscopy within 24 hours of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time to endoscopy outcomes and identify factors affecting delayed endoscopy (>24h of admiss... Read More about Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit.

Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks (2018)
Journal Article
Vidaurre, D., Hunt, L. T., Quinn, A. J., Hunt, B. A. E., Brookes, M. J., Nobre, A. C., & Woolrich, M. W. (2018). Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks. Nature Communications, 9, doi:10.1038/s41467-018-05316-z

Frequency-specific oscillations and phase-coupling of neuronal populations are essential mechanisms for the coordination of activity between brain areas during cognitive tasks. Therefore, the ongoing activity ascribed to the different functional brai... Read More about Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks.

Changes in electrophysiological markers of cognitive control after administration of galantamine (2018)
Journal Article
Gascoyne, L., Mullinger, K., Robson, S., Kumar, J., O'Neill, G. C., Palaniyappan, L., …Liddle, P. F. (2018). Changes in electrophysiological markers of cognitive control after administration of galantamine. NeuroImage: Clinical, 20, (228-235). doi:10.1016/j.nicl.2018.07.019

The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to symptoms o... Read More about Changes in electrophysiological markers of cognitive control after administration of galantamine.

Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function (2018)
Journal Article
Tierney, T. M., Holmes, N., Meyer, S. S., Boto, E., Roberts, G., Leggett, J., …Barnes, G. R. (2018). Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function. NeuroImage, 181, 513-520. https://doi.org/10.1016/j.neuroimage.2018.07.035

Recent work has demonstrated that Optically Pumped Magnetometers (OPMs) can be utilised to create a wearable Magnetoencephalography (MEG) system that is motion robust. In this study, we use this system to map eloquent cortex using a clinically valida... Read More about Cognitive neuroscience using wearable magnetometer arrays: Non-invasive assessment of language function.

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography (2018)
Journal Article
Holmes, N., Leggett, J., Boto, E., Roberts, G., Hill, R. M., Tierney, T. M., …Bowtell, R. (2018). A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography. NeuroImage, 181, 760-774. https://doi.org/10.1016/j.neuroimage.2018.07.028

Small, commercially-available Optically Pumped Magnetometers (OPMs) can be used to construct a wearable Magnetoencephalography (MEG) system that allows large head movements to be made during recording. The small dynamic range of these sensors however... Read More about A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography.

Mapping the topological organisation of beta oscillations in motor cortex using MEG (2018)
Journal Article
Barratt, E., Francis, S. T., Morris, P. G., & Brookes, M. J. (2018). Mapping the topological organisation of beta oscillations in motor cortex using MEG. NeuroImage, doi:10.1016/j.neuroimage.2018.06.041. ISSN 1053-8119

The spatial topology of the human motor cortex has been well studied, particularly using functional Magnetic Resonance Imaging (fMRI) which allows spatial separation of haemodynamic responses arising from stimulation of different body parts, individu... Read More about Mapping the topological organisation of beta oscillations in motor cortex using MEG.

Glutathione and glutamate in schizophrenia: a 7T MRS study (2018)
Journal Article
Kumar, J., Liddle, E. B., Fernandes, C. C., Palaniyappan, L., Hall, E. L., Robson, S. E., …Liddle, P. F. (2018). Glutathione and glutamate in schizophrenia: a 7T MRS study. Molecular Psychiatry, doi:10.1038/s41380-018-0104-7

In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes. Inflammation is associated with increased glutamate, whereas the antioxidant glutathione ma... Read More about Glutathione and glutamate in schizophrenia: a 7T MRS study.