Research Repository

See what's under the surface


Imaging human cortical responses to intraneural microstimulation using magnetoencephalography (2019)
Journal Article
O'Neill, G. C., Watkins, R. H., Ackerley, R., Barratt, E. L., Sengupta, A., Asghar, M., …Francis, S. T. (2019). Imaging human cortical responses to intraneural microstimulation using magnetoencephalography. NeuroImage, 189, 329-340. doi:10.1016/j.neuroimage.2019.01.017

The sensation of touch in the glabrous skin of the human hand is conveyed by thousands of fast-conducting mechanoreceptive afferents, which can be categorised into four distinct types. The spiking properties of these afferents in the periphery in re... Read More

Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit (2018)
Journal Article
Siau, K., Hodson, J., Ingram, R., Baxter, A., Widlak, M. M., Sharratt, C., …Major, G. (2018). Time to endoscopy for acute upper gastrointestinal bleeding: results from a prospective multicentre trainee-led audit. United European Gastroenterology Journal, doi:10.1177/2050640618811491

Background: Endoscopy within 24 hours of admission (early endoscopy) is a quality standard in acute upper gastrointestinal bleeding (AUGIB). We aimed to audit time to endoscopy outcomes and identify factors affecting delayed endoscopy (>24h of admiss... Read More

Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks (2018)
Journal Article
Vidaurre, D., Hunt, L. T., Quinn, A. J., Hunt, B. A. E., Brookes, M. J., Nobre, A. C., & Woolrich, M. W. (2018). Spontaneous cortical activity transiently organises into frequency specific phase-coupling networks. Nature Communications, 9, doi:10.1038/s41467-018-05316-z

Frequency-specific oscillations and phase-coupling of neuronal populations are essential mechanisms for the coordination of activity between brain areas during cognitive tasks. Therefore, the ongoing activity ascribed to the different functional brai... Read More

Changes in electrophysiological markers of cognitive control after administration of galantamine (2018)
Journal Article
Gascoyne, L., Mullinger, K., Robson, S., Kumar, J., O'Neill, G. C., Palaniyappan, L., …Liddle, P. F. (2018). Changes in electrophysiological markers of cognitive control after administration of galantamine. NeuroImage: Clinical, 20, (228-235). doi:10.1016/j.nicl.2018.07.019

The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this. Disruption of this balance could contribute to symptoms o... Read More

Cognitive neuroscience using wearable magnetometer arrays: non-invasive assessment of language function (2018)
Journal Article
Tierney, T. M., Holmes, N., Meyer, S. S., Boto, E., Roberts, G., Leggett, J., …Barnes, G. R. (2018). Cognitive neuroscience using wearable magnetometer arrays: non-invasive assessment of language function. NeuroImage, 181, (513-520). doi:10.1016/j.neuroimage.2018.07.035. ISSN 1053-8119

Recent work has demonstrated that Optically Pumped Magnetometers (OPMs) can be utilised to create a wearable Magnetoencephalography (MEG) system that is motion robust. In this study, we use this system to map eloquent cortex using a clinically valida... Read More

A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography (2018)
Journal Article
Holmes, N., Leggett, J., Boto, E., Roberts, G., Hill, R. M., Tierney, T. M., …Bowtell, R. (2018). A bi-planar coil system for nulling background magnetic fields in scalp mounted magnetoencephalography. NeuroImage, 181, (760-774). doi:10.1016/j.neuroimage.2018.07.028. ISSN 1053-8119

Small, commercially-available Optically Pumped Magnetometers (OPMs) can be used to construct a wearable Magnetoencephalography (MEG) system that allows large head movements to be made during recording. The small dynamic range of these sensors however... Read More

Mapping the topological organisation of beta oscillations in motor cortex using MEG (2018)
Journal Article
Barratt, E., Francis, S. T., Morris, P. G., & Brookes, M. J. (2018). Mapping the topological organisation of beta oscillations in motor cortex using MEG. NeuroImage, doi:10.1016/j.neuroimage.2018.06.041. ISSN 1053-8119

The spatial topology of the human motor cortex has been well studied, particularly using functional Magnetic Resonance Imaging (fMRI) which allows spatial separation of haemodynamic responses arising from stimulation of different body parts, individu... Read More

Glutathione and glutamate in schizophrenia: a 7T MRS study (2018)
Journal Article
Kumar, J., Liddle, E. B., Fernandes, C. C., Palaniyappan, L., Hall, E. L., Robson, S. E., …Liddle, P. F. (2018). Glutathione and glutamate in schizophrenia: a 7T MRS study. Molecular Psychiatry, doi:10.1038/s41380-018-0104-7

In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage following neuroinflammatory processes implicated in acute episodes. Inflammation is associated with increased glutamate, whereas the antioxidant glutathione ma... Read More

Relationships between neuronal oscillatory amplitude and dynamic functional connectivity (2018)
Journal Article
Tewarie, P. K., Hunt, B. A. E., O'Neill, G. C., Byrne, A., Aquino, K., Bauer, M., …Brookes, M. J. (in press). Relationships between neuronal oscillatory amplitude and dynamic functional connectivity. Cerebral Cortex, doi:10.1093/cercor/bhy136. ISSN 1047-3211

Event related fluctuations of neural oscillatory amplitude are reported widely in the context of cognitive processing and are typically interpreted as a marker of brain ‘activity’. However, the precise nature of these effects remains unclear; in part... Read More

Moving magnetoencephalography towards real-world applications with a wearable system (2018)
Journal Article
Boto, E., Holmes, N., Leggett, J., Roberts, G., Shah, V., Meyer, S. S., …Brookes, M. J. (2018). Moving magnetoencephalography towards real-world applications with a wearable system. Nature, 555, doi:10.1038/nature26147. ISSN 0028-0836

Imaging human brain function with techniques such as magnetoencephalography1 (MEG) typically requires a subject to perform tasks whilst their head remains still within a restrictive scanner. This artificial environment makes the technique inaccessibl... Read More

Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment (2018)
Journal Article
Brookes, M. J., Groom, M. J., Liuzzi, L., Hill, R. M., Smith, H. J., Briley, P. M., …Liddle, E. B. (2018). Altered temporal stability in dynamic neural networks underlies connectivity changes in neurodevelopment. NeuroImage, 174, doi:10.1016/j.neuroimage.2018.03.008. ISSN 1053-8119

Network connectivity is an integral feature of human brain function, and characterising its maturational trajectory is a critical step towards understanding healthy and atypical neurodevelopment. Here, we used magnetoencephalography (MEG) to investig... Read More

Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations (2017)
Journal Article
Mandke, K., Meier, J., Brookes, M. J., O'Dea, R. D., Van Mieghem, P., Stam, C. J., …Tewarie, P. K. (2018). Comparing multilayer brain networks between groups: Introducing graph metrics and recommendations. NeuroImage, 166, doi:10.1016/j.neuroimage.2017.11.016. ISSN 1053-8119

There is an increasing awareness of the advantages of multi-modal neuroimaging. Networks obtained from different modalities are usually treated in isolation, which is however contradictory to accumulating evidence that these networks show non-trivial... Read More

Dynamics of large-scale electrophysiological networks: a technical review (2017)
Journal Article
O'Neill, G. C., Tewarie, P. K., Vidaurre, D., Liuzzi, L., Woolrich, M. W., & Brookes, M. J. (2017). Dynamics of large-scale electrophysiological networks: a technical review. NeuroImage, doi:10.1016/j.neuroimage.2017.10.003. ISSN 1053-8119

For several years it has been argued that neural synchronisation is crucial for cognition. The idea that synchronised temporal patterns between different neural groups carries information above and beyond the isolated activity of these groups has ins... Read More

A mean field model for movement induced changes in the beta rhythm (2017)
Journal Article
Byrne, Á., Brookes, M. J., & Coombes, S. (2017). A mean field model for movement induced changes in the beta rhythm. Journal of Computational Neuroscience, 43(2), doi:10.1007/s10827-017-0655-7. ISSN 0929-5313

In electrophysiological recordings of the brain, the transition from high amplitude to low amplitude signals are most likely caused by a change in the synchrony of underlying neuronal population firing patterns. Classic examples of such modulations... Read More

Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study (2017)
Journal Article
Barratt, E. L., Tewarie, P. K., Clarke, M. A., Hall, E. L., Gowland, P. A., Morris, P. G., …Brookes, M. J. (2017). Abnormal task driven neural oscillations in multiple sclerosis: a visuomotor MEG study. Human Brain Mapping, 38(5), doi:10.1002/hbm.23531. ISSN 1065-9471

Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observ... Read More

The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex (2017)
Journal Article
Fry, A., Mullinger, K. J., O'Neill, G. C., Brookes, M. J., & Folland, J. P. (2018). The effect of physical fatigue on oscillatory dynamics of the sensorimotor cortex. Acta Physiologica, 220(3), doi:10.1111/apha.12843. ISSN 1748-1708

Aim: While physical fatigue is known to arise in part from supraspinal mechanisms within the brain exactly how brain activity is modulated during fatigue is not well understood. Therefore, this study examined how typical neural oscillatory responses... Read More

A new generation of magnetoencephalography: room temperature measurements using optically-pumped magnetometers (2017)
Journal Article
Boto, E., Meyer, S. S., Shah, V., Alem, O., Knappe, S., Kruger, P., …Brookes, M. J. (2017). A new generation of magnetoencephalography: room temperature measurements using optically-pumped magnetometers. NeuroImage, 149, doi:10.1016/j.neuroimage.2017.01.034. ISSN 1053-8119

Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperature magnetoencephalog... Read More