All Outputs (48)

Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults (2024)
Journal Article

Although muscle atrophy may partially account for age-related strength decline, it is further influenced by alterations of neural input to muscle. Persistent inward currents (PIC) and the level of common synaptic inputs to motoneurons influence neuro... Read More about Common synaptic inputs and persistent inward currents of vastus lateralis motor units are reduced in older male adults.

The effects of neuromuscular electrical stimulation on hospitalised adults: systematic review and meta-analysis of randomised controlled trials (2023)
Journal Article

Introduction Neuromuscular electrical stimulation (NMES) is a treatment to prevent or reverse acquired disability in hospitalised adults. We conducted a systematic review and meta-analysis of its effectiveness. Method We searched MEDLINE, EMBASE, Cum... Read More about The effects of neuromuscular electrical stimulation on hospitalised adults: systematic review and meta-analysis of randomised controlled trials.

Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function (2023)
Journal Article

Background: Estrogen and progesterone are the primary female sex hormones and have net excitatory and inhibitory effects, respectively, on neuronal function. Fluctuating concentrations across the menstrual cycle has led to several lines of research i... Read More about Menstrual Cycle Associated Alteration of Vastus Lateralis Motor Unit Function.

Acute adaptation of central and peripheral motor unit features to exercise‐induced fatigue differs with concentric and eccentric loading (2023)
Journal Article

New Findings: What is the central question of this study? Conflicting evidence exists on motor unit (MU) firing rate in response to exercise‐induced fatigue, possibly due to the contraction modality used: Do MU properties adapt similarly following co... Read More about Acute adaptation of central and peripheral motor unit features to exercise‐induced fatigue differs with concentric and eccentric loading.

Contrast‐enhanced ultrasound repeatability for the measurement of skeletal muscle microvascular blood flow (2023)
Journal Article

Contrast-enhanced ultrasound (CEUS) can be used to directly assess skeletal muscle perfusion. However, its repeatability over time has not yet been validated and therefore its use in longitudinal measures (i.e., exploring the impact of a chronic inte... Read More about Contrast‐enhanced ultrasound repeatability for the measurement of skeletal muscle microvascular blood flow.

Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy (2022)
Journal Article

Mutations in the dystrophin gene cause Duchenne muscular dystrophy (DMD), a common muscle disease that manifests with muscle weakness, wasting, and degeneration. An emerging theme in DMD pathophysiology is an intramuscular deficit in the gasotransmit... Read More about Sulfur amino acid supplementation displays therapeutic potential in a C. elegans model of Duchenne muscular dystrophy.

Motor unit dysregulation following 15 days of unilateral lower limb immobilisation (2022)
Journal Article

Abstract: Disuse atrophy, caused by situations of unloading such as limb immobilisation, causes a rapid yet diverging reduction in skeletal muscle function when compared to muscle mass. While mechanistic insight into the loss of mass is well studied,... Read More about Motor unit dysregulation following 15 days of unilateral lower limb immobilisation.

Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability (2022)
Journal Article

New Findings: What is the central question of this study? Can bilateral knee extensor force accuracy be improved following 4 weeks of unilateral force accuracy training and are there any subsequent alterations to central and/or peripheral motor unit... Read More about Training-induced improvements in knee extensor force accuracy are associated with reduced vastus lateralis motor unit firing variability.

NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022 (2022)
Working Paper

This paper gives summaries of the keynote lectures given and the research abstracts presented at the NIHR Nottingham Biomedical Research Centre Musculoskeletal theme virtual conference held on 24th and 25th February 2022. The purpose of the confere... Read More about NIHR Nottingham Biomedical Research Centre (BRC) Musculoskeletal theme: virtual conference proceedings 24 th & 25 th February 2022.

Ageing and exercise-induced motor unit remodelling (2022)
Journal Article

A motor unit (MU) comprises the neuron cell body, its corresponding axon and each of the muscle fibres it innervates. Many studies highlight age-related reductions in the number of MUs, yet the ability of a MU to undergo remodelling and to expand to... Read More about Ageing and exercise-induced motor unit remodelling.

Neuromuscular recruitment strategies of the vastus lateralis according to sex (2022)
Journal Article

Aim: Despite males typically exhibiting greater muscle strength and fatigability than females, it remains unclear if there are sex-based differences in neuromuscular recruitment strategies e.g. recruitment and modulation of motor unit firing rate (MU... Read More about Neuromuscular recruitment strategies of the vastus lateralis according to sex.

Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men (2021)
Journal Article

Long-term exercise training has been considered as an effective strategy to counteract age-related hormonal declines and minimise muscle atrophy. However, human data relating circulating hormone levels with motor nerve function are scant. The aims of... Read More about Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men.

Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol (2021)
Working Paper

East Midlands Research into Ageing Network (EMRAN) is a research collaboration across the East Midlands to facilitate collaborative applied clinical research into ageing and the care of older people. EMRAN was set up by NIHR CLAHRC East Midlands and... Read More about Feasibility RCT of neuromuscular electrical stimulation; an Intervention to Maintain and improve neuroMuscular function during periods of Immobility (IMMI): Protocol.

Effects of neuromuscular electrical stimulation (NMES) in acutely hospitalised adult patients -protocol for a systematic review of randomised controlled trials (RCTs) (2021)
Working Paper

Motor Unit Remodelling (2021)
Book Chapter

Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy (2021)
Journal Article

The nematode worm Caenorhabditis elegans has been used extensively to enhance our understanding of the human neuromuscular disorder Duchenne Muscular Dystrophy (DMD). With new arising clinically relevant models, technologies and treatments, there is... Read More about Caenorhabditis elegans as a Model System for Duchenne Muscular Dystrophy.

Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy (2021)
Journal Article

Objective: Disuse atrophy (DA) describes inactivity-induced skeletal muscle loss, through incompletely defined mechanisms. An intriguing observation is that individual muscles exhibit differing degrees of atrophy, despite exhibiting similar anatomica... Read More about Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy.

Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis (2021)
Journal Article

Motor unit (MU) expansion enables rescue of denervated muscle fibres helping to ameliorate age-relatedmuscle atrophy, with evidence to suggest master athletes are more successful at this remodelling. Electrophysiological data has suggested MUs locate... Read More about Lifelong exercise is associated with more homogeneous motor unit potential features across deep and superficial areas of vastus lateralis.

Near-Fiber Electromyography (2021)
Journal Article

Objective Describe and evaluate the concepts of near fiber electromyography (NFEMG), the features used, including near fiber motor unit potential (NFMUP) duration and dispersion, which relate to motor unit distal axonal branch and muscle fiber con... Read More about Near-Fiber Electromyography.

Factors associated with electrical stimulation?induced performance fatigability are dependent upon stimulation location (2021)
Journal Article

Neuromuscular electrical stimulation (NMES) is increasingly viewed as a central tenet to minimise muscle loss during periods of disuse/illness – typically applied directly over a muscle belly. Peripheral nerve stimulation (PNS) is afforded less atten... Read More about Factors associated with electrical stimulation?induced performance fatigability are dependent upon stimulation location.