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Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study (2020)
Journal Article
Fraser, S. D., Barker, J., Roderick, P. J., Yuen, H. M., Shardlow, A., Morris, J. E., …Taal, M. W. (2020). Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study. BMJ Open, 10, Article e040286. https://doi.org/10.1136/bmjopen-2020-040286

Objectives: To determine the associations between comorbidities, health-related quality of life (HRQoL) and functional impairment in people with mild-to-moderate chronic kidney disease (CKD) in primary care.

Design: Cross-sectional analysis at 5-y... Read More about Health-related quality of life, functional impairment and comorbidity in people with mild-to-moderate chronic kidney disease: a cross-sectional study.

Helping people to live well with chronic kidney disease (2020)
Journal Article
Fraser, S., & Taal, M. (2020). Helping people to live well with chronic kidney disease. British Journal of Hospital Medicine, 81(6), https://doi.org/10.12968/hmed.2020.0069

Reduced glomerular filtration rate and presence of albuminuria are both associated with increased risk of several poor outcomes. People with chronic kidney disease also commonly suffer from lower quality of life than their age-matched peers. The expe... Read More about Helping people to live well with chronic kidney disease.

Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study (2020)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2020). Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study. Journal of Human Nutrition and Dietetics, 33(6), 852-861. https://doi.org/10.1111/jhn.12764

Background

Skin autofluorescence (SAF), which is a measure of accumulation of advanced glycation end‐products (AGE), and malnutrition are each associated with higher mortality in dialysis populations, although no studies have investigated these po... Read More about Skin autofluorescence and malnutrition as predictors of mortality in persons receiving dialysis: a prospective cohort study.

Factors associated with change in skin autofluorescence in persons receiving dialysis (2020)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2020). Factors associated with change in skin autofluorescence in persons receiving dialysis. Kidney International Reports, 5(5), 654-662. https://doi.org/10.1016/j.ekir.2020.02.003

Introduction

An increase over time in skin autofluorescence (SAF), a measure of accumulation of advanced glycation end products (AGE), predicts higher mortality on hemodialysis (HD). However, evidence is lacking regarding factors that contribute t... Read More about Factors associated with change in skin autofluorescence in persons receiving dialysis.

SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk (2020)
Journal Article
Schernthaner, G., Groop, P.-H., Kalra, P. A., Ronco, C., & Taal, M. W. (2020). SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk. Diabetes, Obesity and Metabolism, 22(7), 1024-1034. https://doi.org/10.1111/dom.13994

Data from three completed cardiovascular outcome trials (CVOTs), EMPA‐REG OUTCOME, CANVAS Program and DECLARE‐TIMI 58, add to the evidence supporting the potential renoprotective effects of sodium‐glucose linked transporter‐2 (SGLT2) inhibitors in pa... Read More about SGLT‐2 Inhibitor Renal Outcome Modification in Type‐2 Diabetes: Evidence from Studies in Patients with High or Low Renal Risk.

Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study (2020)
Journal Article
Hörner, D. V., Willingham, F. C., Selby, N. M., & Taal, M. W. (2020). Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study. Journal of Renal Nutrition, 30(6), 540-547. https://doi.org/10.1053/j.jrn.2019.12.006

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from oxidative stress and food consumption. We have previously reported that markers of malnutrition are more important determinants of increased skin autofluorescence (S... Read More about Impact of Dietetic Intervention on Skin Autofluorescence and Nutritional Status in Persons Receiving Dialysis: A Proof of Principle Study.

Biological Variation of Cardiac Troponins in Chronic Kidney Disease (2020)
Journal Article
Jones, R., Barrett, J., Brettell, E., Cockwell, P., Dalton, R. N., Deeks, J., …Lamb, E. J. (2020). Biological Variation of Cardiac Troponins in Chronic Kidney Disease. Annals of Clinical Biochemistry, 57(2), 162-169. https://doi.org/10.1177/0004563220906431

Background
Patients with chronic kidney disease often have increased plasma cardiac troponin concentration in the absence of myocardial infarction. Incidence of myocardial infarction is high in this population, and diagnosis, particularly of non ST-... Read More about Biological Variation of Cardiac Troponins in Chronic Kidney Disease.

A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression (2020)
Journal Article
Ali, I., Ibrahim, S. T., Chinnadurai, R., Green, D., Taal, M., Whetton, T. D., & Kalra, P. A. (2020). A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression. Biomarker Insights, 15, 117727192097614. https://doi.org/10.1177/1177271920976146

Biomarker discovery in the field of risk prediction in chronic kidney disease (CKD) embraces the prospect of improving our ability to risk stratify future adverse outcomes and thereby guide patient care in a new era of personalised medicine. However,... Read More about A Paradigm to Discover Biomarkers Associated With Chronic Kidney Disease Progression.

Coffee Consumption and Kidney Function: A Mendelian Randomization Study (2019)
Journal Article
Kennedy, O. J., Pirastu, N., Poole, R., Fallowfield, J. A., Hayes, P. C., Grzeszkowiak, E. J., …Roderick, P. J. (2019). Coffee Consumption and Kidney Function: A Mendelian Randomization Study. American Journal of Kidney Diseases, https://doi.org/10.1053/j.ajkd.2019.08.025

Rationale & Objective

Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. Coffee is a complex mixture of chemicals, and consumption has been associated with mo... Read More about Coffee Consumption and Kidney Function: A Mendelian Randomization Study.

Skin autofluorescence: an emerging biomarker in persons with kidney disease (2019)
Journal Article
Viramontes Horner, D., & Taal, M. W. (2019). Skin autofluorescence: an emerging biomarker in persons with kidney disease. Current Opinion in Nephrology and Hypertension, 28(6), 507–512. https://doi.org/10.1097/MNH.0000000000000549

Purpose of review: Skin autofluorescence (SAF) is a measure of the accumulation of advanced glycation end-products (AGEs) proposed to act as a marker of “cumulative metabolic stress”. This paper discusses mechanisms of AGE formation and reviews publi... Read More about Skin autofluorescence: an emerging biomarker in persons with kidney disease.

Chronic Kidney Disease: call for an age-adapted definition (2019)
Journal Article
Delanaye, P., Jager, K. J., Bökenkamp, A., Christensson, A., Dubourg, L., Eriksen, B. O., …van den Brand, J. A. (2019). Chronic Kidney Disease: call for an age-adapted definition. Journal of the American Society of Nephrology, 30(9), 1785-1805. https://doi.org/10.1681/ASN.2019030238

Current criteria for the diagnosis of chronic kidney disease (CKD) in adults include persistent signs of kidney damage; for example, increased urine albumin-to-creatinine ratio or a glomerular filtration rate (GFR) below the threshold of 60 mL/min pe... Read More about Chronic Kidney Disease: call for an age-adapted definition.

Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease (2019)
Journal Article
Alencar de Pinho, N., Levin, A., Fukagawa, M., Hoy, W. E., Pecoits-Filho, R., Reichel, H., …Stengel, B. (2019). Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease. Kidney International, 96(4), 983-994. https://doi.org/10.1016/j.kint.2019.04.032

Although blood pressure control is a major goal in chronic kidney disease, no worldwide overview of either its achievement or antihypertensive prescriptions is currently available. To evaluate this we compared crude prevalence of uncontrolled blood p... Read More about Considerable international variation exists in blood pressure control and antihypertensive prescription patterns in chronic kidney disease.

Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging (2019)
Journal Article
Buchanan, C. E., Mahmoud, H., Cox, E. F., McCulloch, T., Prestwich, B. L., Taal, M. W., …Francis, S. T. (2020). Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging. Nephrology Dialysis Transplantation, 35(6), 955-964. https://doi.org/10.1093/ndt/gfz129

BACKGROUND:
Multi-parametric magnetic resonance imaging (MRI) provides the potential for a more comprehensive non-invasive assessment of organ structure and function than individual MRI measures, but has not previously been comprehensively evaluated... Read More about Quantitative assessment of renal structural and functional changes in chronic kidney disease using multi-parametric magnetic resonance imaging.

Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease (2019)
Journal Article
Rowe, C., Sitch, A. J., Barratt, J., Brettell, E. A., Cockwell, P., Dalton, R. N., …Lamb, E. J. (2019). Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease. Kidney International, 96(2), 429-435. https://doi.org/10.1016/j.kint.2019.02.021

When assessing changes in glomerular filtration rate (GFR) it is important to differentiate pathological change from intrinsic biological and analytical variation. GFR is measured using complex reference methods (e.g., iohexol clearance). In clinical... Read More about Biological variation of measured and estimated glomerular filtration rate in patients with chronic kidney disease.

Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial (2018)
Journal Article
Haynes, R., Judge, P. K., Staplin, N., Herrington, W. G., Storey, B. C., Bethel, A., …Baigent, C. (2018). Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial. Circulation, 138(15), 1505-1514. https://doi.org/10.1161/CIRCULATIONAHA.118.034818

Background: Sacubitril/valsartan reduces the risk of cardiovascular mortality among patients with heart failure with reduced ejection fraction, but its effects on kidney function and cardiac biomarkers in people with moderate-to-severe chronic kidney... Read More about Effects of Sacubitril/Valsartan Versus Irbesartan in Patients With Chronic Kidney Disease: A Randomized Double-Blind Trial.

The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis (2018)
Journal Article
Viramontes Hörner, D., Selby, N. M., & Taal, M. W. (2019). The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis. Journal of Renal Nutrition, 29(2), 149-155. https://doi.org/10.1053/j.jrn.2018.07.004+hideArticle+Info

Objective: Advanced glycation end-products (AGEs) are uremic toxins that result from hyperglycemia, oxidative stress and systemic inflammation. AGEs are also formed in food during cooking. On the other hand, malnutrition may contribute to AGE formati... Read More about The association of nutritional factors and skin autofluorescence in persons receiving hemodialysis.

The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study (2017)
Journal Article
Shardlow, A., McIntyre, N. J., Fraser, S. D., Roderick, P., Raftery, J., Fluck, R. J., …Taal, M. W. (2017). The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study. PLoS Medicine, 14(10), Article e1002400. https://doi.org/10.1371/journal.pmed.1002400

© 2017 Shardlow et al. Background: To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK and international guidelines recommend that cystatin-C-bas... Read More about The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study.

Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease (2017)
Journal Article
Cox, E. F., Buchanan, C. E., Bradley, C. R., Prestwich, B., Mahmoud, H., Taal, M., Selby, N. M., & Francis, S. T. (2017). Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease. Frontiers in Physiology, 8, Article 696. https://doi.org/10.3389/fphys.2017.00696

Background: This paper outlines a multiparametric renal MRI acquisition and analysis protocol to allow non-invasive assessment of hemodynamics (renal artery blood flow and perfusion), oxygenation (BOLD T2*), and microstructure (diffusion, T1 mapping)... Read More about Multiparametric renal magnetic resonance imaging: validation, interventions, and alterations in chronic kidney disease.