All Outputs (34)

Added dietary cobalt or vitamin B12, or injecting vitamin B12 does not improve performance or indicators of ketosis in pre- and post-partum Holstein-Friesian dairy cows (2018)
Journal Article

Vitamin B12 is synthesised in the rumen from cobalt (Co) and has a major role in metabolism in the peri-paturient period, although few studies have evaluated the effect of the dietary inclusion of Co, vitamin B12 or injecting vitamin B12 on the metab... Read More about Added dietary cobalt or vitamin B12, or injecting vitamin B12 does not improve performance or indicators of ketosis in pre- and post-partum Holstein-Friesian dairy cows.

Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice (2018)
Journal Article

© 2018 National Academy of Sciences. All rights reserved. The association between poor paternal diet, perturbed embryonic development, and adult offspring ill health represents a new focus for the Developmental Origins of Health and Disease hypothesi... Read More about Paternal diet programs offspring health through sperm- and seminal plasma-specific pathways in mice.

When maternal periconceptional diet affects neurological development, it’s time to think (2018)
Journal Article

There is increasing awareness that the nutritional status of women at the onset of pregnancy can have a profound effect on the general health and well-being of children. However, recent analyses indicate that the majority of women from different soci... Read More about When maternal periconceptional diet affects neurological development, it’s time to think.

Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis (2017)
Journal Article

Our recent report detailing the health status of cloned sheep concluded that the animals had aged normally. This is in stark contrast to reports on Dolly (first animal cloned from adult cells) whose diagnoses of osteoarthritis (OA) at 5½ years of age... Read More about Radiographic assessment of the skeletons of Dolly and other clones finds no abnormal osteoarthritis.

Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells (2017)
Journal Article

In storing and transmitting epigenetic information, organisms must balance the need to maintain information about past conditions with the capacity to respond to information in their current and future environments. Some of this information is encode... Read More about Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells.

Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin (2017)
Journal Article

Our understanding of the effects of temperature on granulosa cell (GC) physiology is primarily limited to in vitro studies conducted under atmospheric (approx 20% O2) conditions. In the current series of factorial experiments we identify important ef... Read More about Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin.

Healthy ageing of cloned sheep (2016)
Journal Article

The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detri... Read More about Healthy ageing of cloned sheep.

Epigenetics and developmental programming of welfare and production traits in farm animals (2016)
Journal Article

The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referr... Read More about Epigenetics and developmental programming of welfare and production traits in farm animals.

Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles (2016)
Journal Article

Reproductive management in cattle requires the synchrony of follicle development and oestrus before insemination. However, ovulation of follicles that have not undergone normal physiological maturation can lead to suboptimal luteal function. Here, we... Read More about Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles.

The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals (2016)
Journal Article

The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on... Read More about The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals.

In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver (2015)
Journal Article

Background: Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the levels of the methyl donor vita... Read More about In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver.

Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development (2014)
Journal Article

This paper identifies a common nutritional pathway relating maternal through to fetal protein-energy malnutrition (PEM) and compromised fetal kidney development. Thirty-one twin-bearing sheep were fed either a control (n=15) or low-protein diet (n=16... Read More about Maternal protein-energy malnutrition during early pregnancy in sheep impacts the fetal ornithine cycle to reduce fetal kidney microvascular development.

Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice (2014)
Journal Article

Whilst the association between maternal periconceptional diet and adult offspring health is well characterised, our understanding of the impact of paternal nutrition at the time of conception on offspring phenotype remains poorly defined. Therefore,... Read More about Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice.

Reducing dietary protein in dairy cow diets: implications for nitrogen utilization, milk production, welfare and fertility (2013)
Journal Article

In light of increasing global protein prices and with the need to reduce environmental impact of contemporary systems of milk production, the current review seeks to assess the feasibility of reducing levels of dietary CP in dairy cow diets. At CP le... Read More about Reducing dietary protein in dairy cow diets: implications for nitrogen utilization, milk production, welfare and fertility.