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The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals

Lea, Richard G.; Amezaga, Maria R.; Loup, Benoit; Mandon- Pépin, Béatrice; Stefansdottir, Agnes; Filis, Panagiotis; Kyle, Carol; Zhang, Zulin; Allen, Ceri; Purdie, Laura; Jouneau, Luc; Cotinot, Corinne; Rhind, Stewart M.; Sinclair, Kevin; Fowler, Paul A.

Authors

RICHARD LEA richard.lea@nottingham.ac.uk
Associate Professor and Reader Inreproductive Biology

Maria R. Amezaga

Benoit Loup

Béatrice Mandon- Pépin

Agnes Stefansdottir

Panagiotis Filis

Carol Kyle

Zulin Zhang

Ceri Allen

Laura Purdie

Luc Jouneau

Corinne Cotinot

Stewart M. Rhind

KEVIN SINCLAIR kevin.sinclair@nottingham.ac.uk
Professor of Developmental Biology

Paul A. Fowler



Abstract

The development of fetal ovarian follicles is a critical determinant of adult female reproductive competence. Prolonged exposure to environmental chemicals (ECs) can perturb this process with detrimental consequences for offspring. Here we report on the exposure of pregnant ewes to an environmental mixture of ECs derived from pastures fertilized with sewage sludge (biosolids): a common global agricultural practice. Exposure of pregnant ewes to ECs over 80 day periods during early, mid or late gestation reduced the proportion of healthy early stage fetal follicles comprising the ovarian reserve. Mid and late gestation EC exposures had the most marked effects, disturbing maternal and fetal liver chemical profiles, masculinising fetal anogenital distance and greatly increasing the number of altered fetal ovarian genes and proteins. In conclusion, differential temporal sensitivity of the fetus and its ovaries to EC mixtures has implications for adult ovarian function following adverse exposures during pregnancy.

Journal Article Type Article
Publication Date Mar 2, 2016
Journal Scientific Reports
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 6
Pages 22279
APA6 Citation Lea, R. G., Amezaga, M. R., Loup, B., Mandon- Pépin, B., Stefansdottir, A., Filis, P., …Fowler, P. . A. (2016). The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals. Scientific Reports, 6, 22279. doi:10.1038/srep22279
DOI https://doi.org/10.1038/srep22279
Publisher URL https://www.nature.com/articles/srep22279

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