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Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice

Watkins, Adam J.; Sinclair, Kevin D.

Authors

ADAM WATKINS Adam.Watkins@nottingham.ac.uk
Assistant Professor in Reproductivebiology

KEVIN SINCLAIR kevin.sinclair@nottingham.ac.uk
Professor of Developmental Biology



Abstract

Whilst the association between maternal periconceptional diet and adult offspring health is well characterised, our understanding of the impact of paternal nutrition at the time of conception on offspring phenotype remains poorly defined. Therefore, we determined the effect of a paternal preconception low protein diet (LPD) on adult offspring cardiovascular and metabolic health in mice. Male C57BL/6 mice were fed either normal protein diet (18% casein; NPD) or LPD (9% casein) for 7 weeks prior to mating. At birth, a reduced male:female ratio (P=0.03) and increased male offspring weight (P=0.009) were observed in litters from LPD compared to NPD stud males with no differences in mean litter size. LPD offspring were heavier than NPD offspring at 2 and 3 weeks of age (P

Journal Article Type Article
Publication Date May 15, 2014
Journal American Journal of Physiology – Heart and Circulatory Physiology
Print ISSN 0363-6135
Electronic ISSN 1522-1539
Publisher American Physiological Society
Peer Reviewed Peer Reviewed
Volume 306
Issue 10
Article Number H1444-H1452
APA6 Citation Watkins, A. J., & Sinclair, K. D. (2014). Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice. AJP - Heart and Circulatory Physiology, 306(10), https://doi.org/10.1152/ajpheart.00981.2013
DOI https://doi.org/10.1152/ajpheart.00981.2013
Keywords Adult offspring health, Cardiovascular dysfunction, Developmental programming, Metabolic homeostasis, Paternal diet
Publisher URL http://ajpheart.physiology.org/content/306/10/H1444
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Watkins et al 2014, Am J Phys.pdf (543 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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