Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice

Watkins, Adam J.; Sinclair, Kevin D.

Abstract

Whilst the association between maternal periconceptional diet and adult offspring health is well characterised, our understanding of the impact of paternal nutrition at the time of conception on offspring phenotype remains poorly defined. Therefore, we determined the effect of a paternal preconception low protein diet (LPD) on adult offspring cardiovascular and metabolic health in mice. Male C57BL/6 mice were fed either normal protein diet (18% casein; NPD) or LPD (9% casein) for 7 weeks prior to mating. At birth, a reduced male:female ratio (P=0.03) and increased male offspring weight (P=0.009) were observed in litters from LPD compared to NPD stud males with no differences in mean litter size. LPD offspring were heavier than NPD offspring at 2 and 3 weeks of age (P

Citation

Watkins, A. J., & Sinclair, K. D. (2014). Paternal low protein diet affects adult offspring cardiovascular and metabolic function in mice. AJP - Heart and Circulatory Physiology, 306(10), Article H1444-H1452. https://doi.org/10.1152/ajpheart.00981.2013

• Journal Article Type: Article
• Acceptance Date: Mar 21, 2014
• Publication Date: May 15, 2014
• Deposit Date: Nov 4, 2016
• Publicly Available Date: Nov 4, 2016
• Journal: American Journal of Physiology – Heart and Circulatory Physiology
• Print ISSN: 0363-6135
• Electronic ISSN: 1522-1539
• Publisher: American Physiological Society
• Peer Reviewed: Peer Reviewed
• Volume: 306
• Issue: 10
• Article Number: H1444-H1452
• DOI: https://doi.org/10.1152/ajpheart.00981.2013
• Keywords: Adult offspring health, Cardiovascular dysfunction, Developmental programming, Metabolic homeostasis, Paternal diet
• Public URL: https://nottingham-repository.worktribe.com/output/728728
• Publisher URL: http://ajpheart.physiology.org/content/306/10/H1444