Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation
(2023)
Journal Article
Kopycka, K., Maddison, B. C., & Gough, K. C. (2023). Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation. Scientific Reports, 13(1), Article 3452. https://doi.org/10.1038/s41598-023-30202-0
Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. The central event leading to the pathology in the diseases is the conversion of PrPC into PrPSc and its accumulation in the central nervous system. Previous st... Read More about Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation.