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Circulation of prions within dust on a scrapie affected farm

Gough, Kevin C.; Baker, Claire A.; Simmons, Hugh A.; Hawkins, Steve A.; Maddison, Ben C.

Authors

KEVIN GOUGH kevin.gough@nottingham.ac.uk
Professor of Biochemistry and Pathology

Claire A. Baker

Hugh A. Simmons

Steve A. Hawkins

Ben C. Maddison



Abstract

Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises.

Journal Article Type Article
Publication Date Apr 16, 2015
Journal Veterinary Research
Print ISSN 0928-4249
Electronic ISSN 0928-4249
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 46
APA6 Citation Gough, K. C., Baker, C. A., Simmons, H. A., Hawkins, S. A., & Maddison, B. C. (2015). Circulation of prions within dust on a scrapie affected farm. Veterinary Research, 46, doi:10.1186/s13567-015-0176-1
DOI https://doi.org/10.1186/s13567-015-0176-1
Publisher URL http://www.veterinaryresearch.org/content/46/1/40
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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