Circulation of prions within dust on a scrapie affected farm

Gough, Kevin C.; Baker, Claire A.; Simmons, Hugh A.; Hawkins, Steve A.; Maddison, Ben C.

Abstract

Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises.

Citation

Gough, K. C., Baker, C. A., Simmons, H. A., Hawkins, S. A., & Maddison, B. C. (2015). Circulation of prions within dust on a scrapie affected farm. Veterinary Research, 46, https://doi.org/10.1186/s13567-015-0176-1

• Journal Article Type: Article
• Publication Date: Apr 16, 2015
• Deposit Date: Sep 24, 2015
• Publicly Available Date: Sep 24, 2015
• Journal: Veterinary Research
• Print ISSN: 0928-4249
• Electronic ISSN: 1297-9716
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 46
• DOI: https://doi.org/10.1186/s13567-015-0176-1
• Public URL: https://nottingham-repository.worktribe.com/output/749595
• Publisher URL: http://www.veterinaryresearch.org/content/46/1/40