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Circulation of prions within dust on a scrapie affected farm

Gough, Kevin C.; Baker, Claire A.; Simmons, Hugh A.; Hawkins, Steve A.; Maddison, Ben C.

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Authors

KEVIN GOUGH KEVIN.GOUGH@NOTTINGHAM.AC.UK
Professor of Biochemistry and Pathology

Claire A. Baker

Hugh A. Simmons

Steve A. Hawkins

Ben C. Maddison



Abstract

Prion diseases are fatal neurological disorders that affect humans and animals. Scrapie of sheep/goats and Chronic Wasting Disease (CWD) of deer/elk are contagious prion diseases where environmental reservoirs have a direct link to the transmission of disease. Using protein misfolding cyclic amplification we demonstrate that scrapie PrPSc can be detected within circulating dusts that are present on a farm that is naturally contaminated with sheep scrapie. The presence of infectious scrapie within airborne dusts may represent a possible route of infection and illustrates the difficulties that may be associated with the effective decontamination of such scrapie affected premises.

Citation

Gough, K. C., Baker, C. A., Simmons, H. A., Hawkins, S. A., & Maddison, B. C. (2015). Circulation of prions within dust on a scrapie affected farm. Veterinary Research, 46, https://doi.org/10.1186/s13567-015-0176-1

Journal Article Type Article
Publication Date Apr 16, 2015
Deposit Date Sep 24, 2015
Publicly Available Date Mar 28, 2024
Journal Veterinary Research
Print ISSN 0928-4249
Electronic ISSN 0928-4249
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 46
DOI https://doi.org/10.1186/s13567-015-0176-1
Public URL https://nottingham-repository.worktribe.com/output/749595
Publisher URL http://www.veterinaryresearch.org/content/46/1/40

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