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All Outputs (12)

Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults (2021)
Journal Article
Din, U. S. U., Sian, T. S., Deane, C. S., Smith, K., Gates, A., Lund, J. N., …Phillips, B. E. (2021). Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults. Nutrients, 13(11), Article 3895. https://doi.org/10.3390/nu13113895

Postprandial macro-and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, singleblind, placebo-controlled, crossover trial, we investigated the impa... Read More about Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults.

Omega-3 supplementation during unilateral resistance exercise training in older women: A within subject and double-blind placebo-controlled trial (2021)
Journal Article
Brook, M. S., Din, U., Tarum, J., Selby, A., Quinlan, J., Bass, J. J., …Smith, K. (2021). Omega-3 supplementation during unilateral resistance exercise training in older women: A within subject and double-blind placebo-controlled trial. Clinical Nutrition ESPEN, 46, 394-404. https://doi.org/10.1016/j.clnesp.2021.09.729

Background & aims: The skeletal muscle anabolic effects of n-3 polyunsaturated fatty acids (n-3 PUFA) appear favoured towards women; a property that could be exploited in older women who typically exhibit poor muscle growth responses to resistance ex... Read More about Omega-3 supplementation during unilateral resistance exercise training in older women: A within subject and double-blind placebo-controlled trial.

Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults (2021)
Journal Article
Herrod, P. J., Atherton, P. J., Smith, K., Williams, J. P., Lund, J. N., & Phillips, B. E. (2021). Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults. GeroScience, 43(6), 2667-2678. https://doi.org/10.1007/s11357-021-00463-6

Impairments in muscle microvascular function are associated with the pathogenesis of sarcopenia and cardiovascular disease. High-intensity interval training (HIIT) is an intervention by which a myriad of beneficial skeletal muscle/cardiovascular adap... Read More about Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults.

Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans (2021)
Journal Article
Willis, C. R., Gallagher, I. J., Wilkinson, D. J., Brook, M. S., Bass, J. J., Phillips, B. E., …Atherton, P. J. (2021). Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans. FASEB Journal, 35(9), Article e21830. https://doi.org/10.1096/fj.202100276RR

Muscle disuse leads to a rapid decline in muscle mass, with reduced muscle protein synthesis (MPS) considered the primary physiological mechanism. Here, we employed a systems biology approach to uncover molecular networks and key molecular candidates... Read More about Transcriptomic links to muscle mass loss and declines in cumulative muscle protein synthesis during short-term disuse in healthy younger humans.

Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males (2021)
Journal Article
Quinlan, J. I., Franchi, M. V., Gharahdaghi, N., Badiali, F., Francis, S., Hale, A., …Narici, M. V. (2021). Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males. GeroScience, 43(4), 1567-1584. https://doi.org/10.1007/s11357-021-00396-0

Resistance exercise training (RET) is well-known to counteract negative age-related changes in both muscle and tendon tissue. Traditional RET consists of both concentric (CON) and eccentric (ECC) contractions; nevertheless, isolated ECC contractions... Read More about Muscle and tendon adaptations to moderate load eccentric vs. concentric resistance exercise in young and older males.

Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers (2021)
Journal Article
Deane, C. S., Gates, A., Traviss-Turner, G. D., Wilkinson, D. J., Smith, K., Atherton, P. J., & Phillips, B. E. (2021). Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers. Applied Physiology, Nutrition, and Metabolism, 46(9), 1147-1151. https://doi.org/10.1139/apnm-2021-0204

We explored the views of older (≥65 years) past and potential volunteers in regard to participating in physiology research during the COVID-19 pandemic. Using an online questionnaire and focus groups, we found that past volunteers (n=55) were more li... Read More about Exploring the impact of COVID-19 on the willingness of older adults to participate in physiology research: views from past and potential volunteers.

Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential (2021)
Journal Article
Farrash, W. F., Phillips, B. E., Britton, S. L., Qi, N., Koch, L. G., Wilkinson, D. J., …Atherton, P. J. (2021). Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential. Frontiers in Endocrinology, 12, 1-10. https://doi.org/10.3389/fendo.2021.645881

Introduction: Assuming myokines underlie some of the health benefits of exercise, we hypothesised that ‘high responder trainer’ (HRT) rats would exhibit distinct myokine profiles to ‘low responder trainers’ (LRT), reflecting distinct health and adapt... Read More about Myokine Responses to Exercise in a Rat Model of Low/High Adaptive Potential.

The physiological impact of high‐intensity interval training in octogenarians with comorbidities (2021)
Journal Article
Blackwell, J. E., Gharahdaghi, N., Brook, M. S., Watanabe, S., Boereboom, C. L., Doleman, B., …Phillips, B. E. (2021). The physiological impact of high‐intensity interval training in octogenarians with comorbidities. Journal of Cachexia, Sarcopenia and Muscle, 12(4), 866-879. https://doi.org/10.1002/jcsm.12724

Background Declines in cardiorespiratory fitness (CRF) and fat-free mass (FFM) with age are linked to mortality, morbidity and poor quality of life. High-intensity interval training (HIIT) has been shown to improve CRF and FFM in many groups, but it... Read More about The physiological impact of high‐intensity interval training in octogenarians with comorbidities.

Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach (2021)
Journal Article
Cegielski, J., Wilkinson, D. J., Brook, M. S., Boereboom, C., Phillips, B. E., Gladman, J. F. R., …Atherton, P. J. (2021). Combined in vivo muscle mass, muscle protein synthesis and muscle protein breakdown measurement: a ‘Combined Oral Stable Isotope Assessment of Muscle (COSIAM)’ approach. GeroScience, https://doi.org/10.1007/s11357-021-00386-2

Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy (2021)
Journal Article
Hardy, E., Inns, T., Wilkinson, D., Piasecki, M., Atherton, P., Phillips, B., …Smith, K. (2021). Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy. Frontiers in Psychology, 12, Article 653060. https://doi.org/10.3389/fphys.2021.653060

Objective: Disuse atrophy (DA) describes inactivity-induced skeletal muscle loss, through incompletely defined mechanisms. An intriguing observation is that individual muscles exhibit differing degrees of atrophy, despite exhibiting similar anatomica... Read More about Atrophy Resistant vs. Atrophy Susceptible skeletal muscles: “aRaS” as a novel experimental paradigm to study the mechanisms of human disuse atrophy.

A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men (2021)
Journal Article
Brook, M., Scaife, P., Bass, J., Cegielski, J., Watanabe, S., Wilkinson, D., …Atherton, P. (2021). A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men. Clinical Nutrition, 40(6), 4456-4464. https://doi.org/10.1016/j.clnu.2021.01.002

Background & aims: Nutritional composition is key for skeletal muscle maintenance into older age. Yet the acute effects of collagen protein blended with other protein sources, in relation to skeletal muscle anabolism, are ill-defined. We investigated... Read More about A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men.