All Outputs (34)

Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men (2022)
Journal Article
Abdulla, H., Phillips, B., Wilkinson, D., Gates, A., Limb, M., Jandova, T., …Atherton, P. (2023). Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men. Journal of Clinical Endocrinology and Metabolism, 108(4), 971-978. https://doi.org/10.1210/clinem/dgac613

Introduction Ageing skeletal muscles become both insulin resistant and atrophic. The hormone glucagon-like peptide 1 (GLP-1) facilitates postprandial glucose uptake as well as augmenting muscle perfusion, independent of insulin action. We thus hypot... Read More about Effects of GLP-1 Infusion Upon Whole-body Glucose Uptake and Skeletal Muscle Perfusion During Fed-state in Older Men.

Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults (2021)
Journal Article
Din, U. S. U., Sian, T. S., Deane, C. S., Smith, K., Gates, A., Lund, J. N., …Phillips, B. E. (2021). Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults. Nutrients, 13(11), Article 3895. https://doi.org/10.3390/nu13113895

Postprandial macro-and microvascular blood flow and metabolic dysfunction manifest with advancing age, so vascular transmuting interventions are desirable. In this randomised, singleblind, placebo-controlled, crossover trial, we investigated the impa... Read More about Green Tea Extract Concurrent with an Oral Nutritional Supplement Acutely Enhances Muscle Microvascular Blood Flow without Altering Leg Glucose Uptake in Healthy Older Adults.

Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults (2021)
Journal Article
Herrod, P. J., Atherton, P. J., Smith, K., Williams, J. P., Lund, J. N., & Phillips, B. E. (2021). Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults. GeroScience, 43(6), 2667-2678. https://doi.org/10.1007/s11357-021-00463-6

Impairments in muscle microvascular function are associated with the pathogenesis of sarcopenia and cardiovascular disease. High-intensity interval training (HIIT) is an intervention by which a myriad of beneficial skeletal muscle/cardiovascular adap... Read More about Six weeks of high-intensity interval training enhances contractile activity induced vascular reactivity and skeletal muscle perfusion in older adults.

Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery (2021)
Journal Article
Read, D., Doleman, B., Heinink, T., Selby, N., Lund, J., Phillips, B., & Williams, J. (2021). Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery. Clinical and Experimental Pharmacology and Physiology, 48(7), 971-977. https://doi.org/10.1111/1440-1681.13501

Colorectal surgery is associated with an above‐average mortality rate of ~15%. During surgery, maintenance of vital organ perfusion is essential in order to reduce postoperative mortality and morbidity, with renal perfusion of particular importance.... Read More about Contrast‐enhanced ultrasound assessed renal microvascular perfusion may predict postoperative renal complications following colorectal surgery.

Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age (2020)
Journal Article
Sayda, M. H., Phillips, B. E., Williams, J. P., Greenhaff, P. L., Wilkinson, D. J., Smith, K., & Atherton, P. J. (2020). Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age. Nutrients, 12(10), Article 3029. https://doi.org/10.3390/nu12103029

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Leucine, isoleucine and valine (i.e., the branched chain amino acids, BCAA) play a key role in the support and regulation of tissue protein regulation and also as energy substrates. However, p... Read More about Associations between plasma branched chain amino acids and health biomarkers in response to resistance exercise training across age.

Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle (2020)
Journal Article
Abdulla, H., Phillips, B. E., Wilkinson, D. J., Limb, M., Jandova, T., Bass, J. J., …Atherton, P. J. (2020). Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle. Aging Cell, 19(9), Article e13202. https://doi.org/10.1111/acel.13202

© 2020 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd Background: Despite its known insulin-independent effects, glucagon-like peptide-1 (GLP-1) role in muscle protein turnover has not been explored under fed-stat... Read More about Glucagon-like peptide 1 infusions overcome anabolic resistance to feeding in older human muscle.

Funnel plots may show asymmetry in the absence of publication bias with continuous outcomes dependent on baseline risk: presentation of a new publication bias test (2020)
Journal Article
Doleman, B., Freeman, S. C., Lund, J. N., Williams, J. P., & Sutton, A. J. (2020). Funnel plots may show asymmetry in the absence of publication bias with continuous outcomes dependent on baseline risk: presentation of a new publication bias test. Research Synthesis Methods, 11(4), 522-534. https://doi.org/10.1002/jrsm.1414

This study aimed to determine for continuous outcomes dependent on baseline risk, whether funnel plot asymmetry may be due to statistical artefact rather than publication bias and evaluate a novel test to resolve this. Firstly, we conducted assessmen... Read More about Funnel plots may show asymmetry in the absence of publication bias with continuous outcomes dependent on baseline risk: presentation of a new publication bias test.

Trainee-led emergency laparotomy operating (2020)
Journal Article
Boyd-Carson, H., Doleman, B., Lockwood, S., Williams, J. P., Tierney, G. M., & Lund, J. N. (2020). Trainee-led emergency laparotomy operating. British Journal of Surgery, 107(10), 1289-1298. https://doi.org/10.1002/bjs.11611

© 2020 BJS Society Ltd Published by John Wiley & Sons Ltd Background: To achieve completion of training in general surgery, trainees are required to demonstrate competency in common procedures performed at emergency laparotomy. The aim of this stud... Read More about Trainee-led emergency laparotomy operating.

Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients (2019)
Journal Article
Thomas, P. W., Blackwell, J. E. M., Herrod, P. J. J., Peacock, O., Singh, R., Williams, J. P., …Lund, J. N. (2019). Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients. Techniques in Coloproctology, 23(8), 761-767. https://doi.org/10.1007/s10151-019-02056-0

Background Current evidence suggests that pelvic floor reconstruction following extralevator abdominoperineal excision of rectum (ELAPER) may reduce the risk of perineal herniation of intra-abdominal contents. Options for reconstruction include mesh... Read More about Long-term outcomes of biological mesh repair following extra levator abdominoperineal excision of the rectum: an observational study of 100 patients.

Association between surgeon special interest and mortality after emergency laparotomy (2019)
Journal Article
Boyd‐Carson, H., Doleman, B., Herrod, P. J. J., Anderson, I. D., Williams, J. P., Lund, J. N., …on behalf of the NELA Collaboration. (2019). Association between surgeon special interest and mortality after emergency laparotomy. British Journal of Surgery, 106(7), 940-948. https://doi.org/10.1002/bjs.11146

© 2019 BJS Society Ltd Published by John Wiley & Sons Ltd Background: Approximately 30 000 emergency laparotomies are performed each year in England and Wales. Patients with pathology of the gastrointestinal tract requiring emergency laparotomy are... Read More about Association between surgeon special interest and mortality after emergency laparotomy.

The acute transcriptional response to resistance exercise: impact of age and contraction mode (2019)
Journal Article
Deane, C. S., Ames, R. M., Phillips, B. E., Weedon, M. N., Willis, C. R., Boereboom, C., …Etheridge, T. (2019). The acute transcriptional response to resistance exercise: impact of age and contraction mode. Aging, 11(7), 2111-2126. https://doi.org/10.18632/aging.101904

Optimization of resistance exercise (RE) remains a hotbed of research for muscle building and maintenance. However, the interactions between the contractile components of RE (i.e. concentric (CON) and eccentric (ECC)) and age, are poorly defined. We... Read More about The acute transcriptional response to resistance exercise: impact of age and contraction mode.

Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection (2019)
Journal Article
Herrod, P. J., Boyd-Carson, H., Doleman, B., Trotter, J., Schlichtemeier, S., Sathanapally, G., …Lund, J. N. (2019). Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection. Techniques in Coloproctology, 23(2), 129–134. https://doi.org/10.1007/s10151-019-1928-0

Purpose: Radiologically-defined sarcopenia has been shown to predict negative outcomes after cancer surgery, however radiological assessment of sarcopenia often requires additional software and standardisation against anthropomorphic data. Measuring... Read More about Quick and simple: psoas density measurement is an independent predictor of anastomotic leak and other complications after colorectal resection.

The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females (2018)
Journal Article
Herrod, P. J. J., Blackwell, J. E. M., Moss, B. F., Gates, A., Atherton, P. J., Lund, J. N., …Phillips, B. E. (2019). The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females. European Journal of Applied Physiology, 119(3), 645-652. https://doi.org/10.1007/s00421-018-4054-1

PURPOSE: Cardiovascular disease (CVD) is the leading cause of death worldwide. Many risk factors for CVD can be modified pharmacologically; however, uptake of medications is low, especially in asymptomatic people. Exercise is also effective at reduc... Read More about The efficacy of ‘static’ training interventions for improving indices of cardiorespiratory fitness in premenopausal females.

Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol) (2018)
Journal Article
Doleman, B., Leonardi-Bee, J., Heinink, T. P., Lund, J., & Williams, J. P. (2018). Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol). Cochrane Database of Systematic Reviews, 3, https://doi.org/10.1002/14651858.CD012978

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate in adult participants undergoing all types of surgery, the effects of pre-emptive and preventive non-steroidal anti-inflammatory drugs (NSAIDs) com... Read More about Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery (Protocol).

Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men (2017)
Journal Article
Mitchell, W. K., Phillips, B. E., Hill, I., Greenhaff, P. L., Lund, J. N., Williams, J. P., …Atherton, P. J. (2017). Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men. Clinical Science, 131(21), https://doi.org/10.1042/CS20171230

Leucine modulates muscle protein synthesis (MPS), with potential to facilitate accrual/maintenance of muscle mass. Animal models suggest that leucine boluses shortly after meals may prolong MPS and delay onset of a “muscle-full” state. However, the e... Read More about Human skeletal muscle is refractory to the anabolic effects of leucine during the postprandial muscle-full period in older men.

Physiological adaptations to resistance exercise as a function of age (2017)
Journal Article
Phillips, B. E., Williams, J. P., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2017). Physiological adaptations to resistance exercise as a function of age. JCI insight, 2(17), Article e95581. https://doi.org/10.1172/jci.insight.95581

BACKGROUND. The impact of resistance exercise training (RE-T) across the life span is poorly defined. METHODS. To resolve this, we recruited three distinct age cohorts of young (18–28 years; n = 11), middle-aged (45–55 years; n = 20), and... Read More about Physiological adaptations to resistance exercise as a function of age.

Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates (2017)
Journal Article
Doleman, B., Sutton, A. J., Sherwin, M., Lund, J. N., & Williams, J. P. (2018). Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates. Anesthesia and Analgesia, 126(2), 648-660. https://doi.org/10.1213/ANE.0000000000002237

BACKGROUND: Statistical heterogeneity can increase the uncertainty of results and reduce the quality of evidence derived from systematic reviews. At present, it is uncertain what the major factors are that account for heterogeneity in meta-analyses o... Read More about Baseline morphine consumption may explain between-study heterogeneity in meta-analyses of adjuvant analgesics and improve precision and accuracy of effect estimates.

Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers (2017)
Journal Article
Heinink, T. P., Read, D. J., Mitchell, W. K., Bhalla, A., Lund, J. N., Phillips, B. E., & Williams, J. P. (2018). Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers. Clinical Physiology and Functional Imaging, 38(2), 213-219. https://doi.org/10.1111/cpf.12401

Background Oesophageal Doppler monitoring (ODM) is used clinically to optimize cardiac output (CO) and guide fluid therapy. Despite limited experimental evidence, it is assumed that increasing CO increases visceral microvascular blood flow (MBF).... Read More about Oesophageal Doppler guided optimization of cardiac output does not increase visceral microvascular blood flow in healthy volunteers.

Fibrin glue for pilonidal sinus disease (2017)
Journal Article
Lund, J. N., Tou, S., Doleman, B., & Williams, J. P. (in press). Fibrin glue for pilonidal sinus disease. Cochrane Database of Systematic Reviews, 2017(1), Article CD011923. https://doi.org/10.1002/14651858.CD011923.pub2

Background Pilonidal sinus disease is a common condition that mainly affects young adults. This condition can cause significant pain and impairment of normal activities. No consensus currently exists on the optimum treatment for pilonidal sinus and... Read More about Fibrin glue for pilonidal sinus disease.

Simulation fails to replicate stress in trainees performing a technical procedure in the clinical environment (2016)
Journal Article
Baker, B., Bhalla, A., Doleman, B., Yarnold, E., Simons, S., Lund, J. N., & Williams, J. P. (in press). Simulation fails to replicate stress in trainees performing a technical procedure in the clinical environment. Medical Teacher, 39(1), https://doi.org/10.1080/0142159X.2016.1230188

Introduction: Simulation-based training (SBT) has become an increasingly important method by which doctors learn. Stress has an impact upon learning, performance, technical, and non-technical skills. However, there are currently no studies that compa... Read More about Simulation fails to replicate stress in trainees performing a technical procedure in the clinical environment.