All Outputs (85)

The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae (2024)
Journal Article

Maximising the yield of product from livestock is common practice in the agriculture industry and there is potential to extend this practice to the emerging insect industry, to produce high-quality, sustainable protein. Tenebrio molitor larvae, commo... Read More about The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae.

Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter (2024)
Journal Article

Background: Skeletal muscle development during embryogenesis depends on proliferation of myoblasts followed by differentiation into myotubes/multinucleated myofibers. Vitamin D (VD) has been shown to affect these processes, but there is conflicting e... Read More about Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter.

Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor) (2023)
Journal Article

Insects are of high interest as a sustainable source of nutrients to be included in the food production system. The larvae of Tenebrio molitor, commonly known as yellow mealworms (MW), have a high protein content, which means potential applications i... Read More about Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor).

In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method. (2023)
Journal Article

There is an urgent need to alleviate protein deficiencies in low-income countries where cereal-based diets dominate. The objective of this study was to use the INFOGEST static digestion method and a recently established analytical workflow to determi... Read More about In vitro determination of the protein quality of maize varieties cultivated in Malawi using the INFOGEST digestion method..

Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review (2023)
Journal Article

Bambara groundnut (BG) offers great potential for sustainable food and nutritional security in the face of a growing population and changing climate. However, its utilization remains restricted by the hard-to-cook phenomenon of seed and the presence... Read More about Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review.

A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation (2022)
Journal Article

Non-alcoholic fatty liver disease (NAFLD) begins with lipid accumulation within hepatocytes, but the relative contributions of different macronutrients is still unclear. We investigated the impact of fatty acids, glucose and fructose on lipid accumul... Read More about A Comparison of Primary Human Hepatocytes and Hepatoma Cell Lines to Model the Effects of Fatty Acids, Fructose and Glucose on Liver Cell Lipid Accumulation.

The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat (2022)
Journal Article

Wheat is a widely used cereal grain for pig and poultry feeds globally. Despite this, there are noticeable differences in its nutritive value, potentially due to varying characteristics like inherent non-starch polysaccharide (NSP) content and compos... Read More about The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat.

The Winged Bean Genome: Winged Bean—One Species Supermarket (2022)
Book Chapter

Climate change, population growth and increasingly homogenised diets are a threat to food security and human nutritional status. There is an urgent need to incorporate highly nutritious crops into the human diet to provide new sources of nutrition, t... Read More about The Winged Bean Genome: Winged Bean—One Species Supermarket.

The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type (2022)
Journal Article

Fibrolytic enzymes are routinely added to non-ruminant livestock feeds to help degrade the non-starch polysaccharide (NSP) contents and thereby improve feed efficiency. This study investigated the range of xylooligosaccharides (XOS) and monosaccharid... Read More about The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type.

Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle (2021)
Journal Article

We previously reported that growth promoter-induced skeletal muscle hypertrophy co-ordinately upregulated expression of genes associated with an integrated stress response (ISR), as well as potential ISR regulators. We therefore used Adeno-Associated... Read More about Effect of AAV-mediated overexpression of ATF5 and downstream targets of an integrated stress response in murine skeletal muscle.

In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review (2021)
Journal Article

Vitamin D (VD) deficiency is associated with muscle weakness. A reduction in the incidence of falls in the elderly following VD supplementation and identification of the VD receptor within muscle cells suggests a direct effect of VD on muscle, but li... Read More about In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review.

Suitability of insects for animal feeding. (2021)
Book Chapter

This chapter explores the nutritional composition of insects and the potential benefits and drawbacks for their inclusion into pet, poultry, pig, ruminant and aquatic animal feeds. Six species are most commonly described for use in animal feed, namel... Read More about Suitability of insects for animal feeding..

98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance (2021)
Journal Article

Application Inclusion of Mezquite pod flour in broiler chicken diets significantly reduced weight gain, this could inform a recommendation against the use of non-processed Mezquite in broiler chicken diets. Introduction Mezquite is an under-utilised... Read More about 98 The effect of mezquite pod flour in a wheat-based diet on broiler chicken growth performance.

Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro (2021)
Journal Article

© 2021 The Authors Myosin heavy chain-IIB (MyHC-IIB; encoded by MYH4 or Myh4) expression is often associated with muscle hypertrophic growth. Unlike other large mammals, domestic pig breeds express MyHC-IIB at both the mRNA and protein level. Aim: To... Read More about Response of the porcine MYH4-promoter and MYH4-expressing myotubes to known anabolic and catabolic agents in vitro.

The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells (2020)
Journal Article

Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells... Read More about The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells.

Insects: A Potential Source of Protein and Other Nutrients for Feed and Food (2020)
Journal Article

© 2021 Annual Reviews Inc.. All rights reserved. Sustainable production of healthy food for a growing global population, in the face of the uncertainties of climate change, represents a major challenge for the coming decade. Livestock provide food wi... Read More about Insects: A Potential Source of Protein and Other Nutrients for Feed and Food.

The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet (2020)
Journal Article

1. This study aimed to quantify xylanase-induced changes in soluble monosaccharides, xylooligosaccharides (XOS) and volatile fatty acid (VFA) contents of the different sections of the GIT and whether these relate to altered bird performance. 2. An... Read More about The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet.

Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes (2020)
Journal Article

© 2020, The Author(s). Chronic mTORc1 hyperactivation via obesity-induced hyperleucinaemia has been implicated in the development of insulin resistance, yet the direct impact of leucine on insulin-stimulated glucose uptake in muscle cells remains unc... Read More about Leucine and mTORc1 act independently to regulate 2-deoxyglucose uptake in L6 myotubes.

Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2019)
Journal Article

© 2019, The Author(s). In the Supplementary Information file originally published with this Article, Table 2 was omitted. This error has been corrected in the Supplementary Information that now accompanies the Article.

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells (2019)
Journal Article

Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is... Read More about Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells.