All Outputs (96)

A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data (2021)
Preprint / Working Paper
Bishton, M., Stilwell, P., Card, T. R., Lanyon, P., Ban, L., Elliss-Brookes, L., …Bythell, M. A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data

We assessed the validity of coded health care data to identify cases of haemophagocytic lymphohistiocytosis (HLH). Hospital Episode Statistics (HES) identified 127 cases within five hospital Trusts 2013-2018 using ICD-10 codes D76.1, D76.2 and D76.3.... Read More about A validation study of the identification of haemophagocytic lymphohistiocytosis in England using population-based health data.

Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study (2021)
Journal Article
Adiamah, A., Ban, L., Otete, H., Crooks, C. J., West, J., & Humes, D. J. (2021). Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study. BJS Open, 5(2), Article zraa073. https://doi.org/10.1093/bjsopen/zraa073

BACKGROUND: The management of perforated diverticular disease has changed in the past 10 years with a move towards less surgical intervention. This population-based cohort study aimed to define the risk of death and readmission following non-operativ... Read More about Outcomes after non-operative management of perforated diverticular disease: a population-based cohort study.

We need stronger evidence for (or against) hepatocellular carcinoma surveillance (2021)
Journal Article
Jepsen, P., & West, J. (2021). We need stronger evidence for (or against) hepatocellular carcinoma surveillance. Journal of Hepatology, 74(5), 1234-1239. https://doi.org/10.1016/j.jhep.2020.12.029

Current guidelines from EASL recommend that most patients with cirrhosis are offered surveillance for hepatocellular carcinoma (HCC), but fewer than expected patients actually receive it. The recommendation is based on observational studies and simul... Read More about We need stronger evidence for (or against) hepatocellular carcinoma surveillance.

Long term health related quality of life following colorectal cancer surgery: patient reported outcomes in a remote follow-up population (2020)
Journal Article
Malcolm, F., Adiamah, A., Banerjea, A., Whitehead, D., Gupta, A., West, J., & Humes, D. (2021). Long term health related quality of life following colorectal cancer surgery: patient reported outcomes in a remote follow-up population. Colorectal Disease, 23(1), 213-225. https://doi.org/10.1111/codi.15393

Background: Remote follow-up (RFU) after colorectal cancer (CRC) surgery allows delivery of surveillance tests without the need for regular outpatient clinical appointments. However, little is known about health related quality of life (HRQoL) in RFU... Read More about Long term health related quality of life following colorectal cancer surgery: patient reported outcomes in a remote follow-up population.

COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study (2020)
Journal Article
Manson, J. J., Crooks, C., Naja, M., Ledlie, A., Goulden, B., Liddle, T., …Tattersall, R. (2020). COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study. The Lancet Rheumatology, 2(10), e594-e602. https://doi.org/10.1016/S2665-9913%2820%2930275-7

Background: A subset of patients with severe COVID-19 develop a hyperinflammatory syndrome, which might contribute to morbidity and mortality. This study explores a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associa... Read More about COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.

Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway (2020)
Journal Article
Tildesley, Z., Chalmers, J., Harris, R., West, J., Guha, I. N., & Morling, J. R. (2020). Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway. Public Health In Practice, 1, Article 100033. https://doi.org/10.1016/j.puhip.2020.100033

Objectives: There is a lack of understanding of health related quality of life (HRQoL) in chronic liver disease (CLD). With the rising prevalence of alcohol and obesity driven CLD, and the increasing ability to screen for fibrosis, it is important to... Read More about Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway.

Risk of hepatocellular carcinoma in Danish outpatients with alcohol-related cirrhosis (2020)
Journal Article
Jepsen, P., Kraglund, F., West, J., Villadsen, G. E., Toft Sørensen, H., & Vilstrup, H. (2020). Risk of hepatocellular carcinoma in Danish outpatients with alcohol-related cirrhosis. Journal of Hepatology, 73(5), 1030-1036. https://doi.org/10.1016/j.jhep.2020.05.043

Background and aims: Accurate estimates of the risk of hepatocellular carcinoma (HCC) in patients with cirrhosis are important for clinical decisions about HCC surveillance. We described HCC risk among outpatients with alcoholic cirrhosis and contras... Read More about Risk of hepatocellular carcinoma in Danish outpatients with alcohol-related cirrhosis.

Editorial: how widespread and serious is non-alcoholic fatty liver disease in the real world? (2020)
Journal Article
Harris, R., West, J., & Morling, J. R. (2020). Editorial: how widespread and serious is non-alcoholic fatty liver disease in the real world?. Alimentary Pharmacology and Therapeutics, 51(11), 1199-1200. https://doi.org/10.1111/apt.15714

Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study (2020)
Journal Article
Grønbæk, L., Otete, H., Ban, L., Crooks, C., Card, T., Jepsen, P., & West, J. (2020). Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study. Liver International, 40(7), 1634-1644. https://doi.org/10.1111/liv.14480

© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background & Aims: There are few population-based studies of the incidence and mortality of autoimmune hepatitis. The burden of the disease and how it has changed over time have not... Read More about Incidence, prevalence and mortality of autoimmune hepatitis in England 1997-2015. A population-based cohort study.

Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study (2019)
Journal Article
West, J., Otete, H., Sultan, A. A., & Crooks, C. J. (2019). Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study. Epidemiology, 30(4), e23-e24. https://doi.org/10.1097/EDE.0000000000001006

The diagnosis rates of coeliac disease differ substantially between countries. Intriguingly, there has been recent evidence from Olmstead County, USA and Finland that in the last 5-10 years incidence has plateaued or even declined. In most population... Read More about Changes in the testing for and incidence of celiac disease in the UK 2005-2015: a population based cohort study.

Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study (2019)
Journal Article
Henry, M., Abdul-Sultan, A., Walker, A., West, J., & Humes, D. (2019). Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study. Digestive Surgery, 37(1), 32-38. https://doi.org/10.1159/000496435

Background:
This study aimed to identify burden and risk of VTE associated with cholecystectomy in England.

Methods:
An historical cohort study of cholecystectomy patients from 2001-2011 was undertaken using linked primary (Clinical Practice... Read More about Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study.

Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort (2018)
Journal Article
Quarpong, W., Card, T. R., West, J., Solaymani-Dodaran, M., Logan, R. F., & Grainge, M. J. (2019). Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort. United European Gastroenterology Journal, 7(3), 377-387. https://doi.org/10.1177/2050640618814662

Background: Few studies have determined the very long-term mortality risks in adult and childhood-diagnosed coeliac disease.

Objective: We quantified mortality risks in coeliac disease and determined whether age at diagnosis, or time following di... Read More about Mortality in people with coeliac disease: long-term follow-up from a Scottish cohort.

Time out of general surgery specialty training in the UK: a national database study (2018)
Journal Article
Elsey, E. J., West, J., Griffiths, G., & Humes, D. J. (2019). Time out of general surgery specialty training in the UK: a national database study. Journal of Surgical Education, 76(1), 55-64. https://doi.org/10.1016/j.jsurg.2018.06.011

Objective:General surgery specialty training in the UK takes 6 years and allows trainees to take time out of training. Studies from the USA have highlighted an increasing trend for taking time out of surgical training for research. This study aimed t... Read More about Time out of general surgery specialty training in the UK: a national database study.

Injury among children and young people with and without attention deficit-hyperactivity disorder in the community: the risk of fractures, thermal injuries and poisonings (2018)
Journal Article
Prasad, V., West, J., Sayal, K., & Kendrick, D. (2018). Injury among children and young people with and without attention deficit-hyperactivity disorder in the community: the risk of fractures, thermal injuries and poisonings. Child: Care, Health and Development, 44(6), 871-878. https://doi.org/10.1111/cch.12591

Background: Injuries commonly cause morbidity and mortality in children and young people (CYP). Attention deficit-hyperactivity disorder (ADHD) is the commonest neurobehavioural disorder in CYP and is associated with increased injury risk. However, l... Read More about Injury among children and young people with and without attention deficit-hyperactivity disorder in the community: the risk of fractures, thermal injuries and poisonings.

Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data (2018)
Journal Article
Otete, H. E., Deleuran, T., Fleming, K. M., Card, T. R., Aithal, G. P., Jepsen, P., & West, J. (2018). Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data. Journal of Hepatology, 69(3), 697-704. https://doi.org/10.1016/j.jhep.2018.04.002

Background & aims: Cirrhosis is a risk factor for osteoporosis and fractures. However, little is known of the actual risk of hip fractures in patients with alcoholic cirrhosis. Using linked primary and secondary care data from the English and Danish... Read More about Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data.

Attention-deficit/hyperactivity disorder: variation by socio-economic deprivation (2018)
Journal Article
Prasad, V., West, J., Kendrick, D., & Sayal, K. (2019). Attention-deficit/hyperactivity disorder: variation by socio-economic deprivation. Archives of Disease in Childhood, 104(8), 802-805. https://doi.org/10.1136/archdischild-2017-314470

Background: In England, there is a discrepancy between the prevalence of Attention-deficit/hyperactivity disorder (ADHD) ascertained from medical records and community surveys. There is also a lack of data on variation in recorded prevalence by depri... Read More about Attention-deficit/hyperactivity disorder: variation by socio-economic deprivation.

A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink (2018)
Journal Article
Crooks, C. J., West, J., & Jepson, P. (2018). A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink. Clinical Epidemiology, 2018:10, https://doi.org/10.2147/CLEP.S147535

Purpose: The CirCom score has been developed from Danish data as a specific measure of comorbidity for cirrhosis to predict all-cause mortality. We compared its performance with the Charlson Comorbidity Index (CCI) in an English cirrhosis population.... Read More about A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink.

Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly? (2017)
Journal Article
Ratib, S., West, J., & Fleming, K. M. (2017). Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?. BMJ Open, 7(7), Article e013752. https://doi.org/10.1136/bmjopen-2016-013752

Objectives: Mortality due to liver disease (of which cirrhosis is the end‐stage) is increasing more than any other chronic condition in the UK. This study aims to demonstrate that (i) exclusive reliance on mortality rates may not reveal the true burd... Read More about Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?.

Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry (2017)
Journal Article
Davies, M., West, J., Williams, C., & Gardner, D. S. (in press). Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry. Veterinary Record, 180(18), https://doi.org/10.1136/vr.103953

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs... Read More about Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry.

Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study (2017)
Journal Article
West, J., Card, T. R., Aithal, G. P., & Fleming, K. M. (2017). Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study. Alimentary Pharmacology and Therapeutics, 45(7), 983-990. https://doi.org/10.1111/apt.13961

Background: Among patients with cirrhosis, only those determined to be at risk for hepatocellular carcinoma (HCC) should undergo surveillance. However, little is known about how different aetiologies of cirrhosis affect risk for HCC.
Aim: To quantif... Read More about Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study.