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Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study

Henry, M.L.; Abdul-Sultan, A.; Walker, A.J.; West, J.; Humes, D.J.

Authors

M.L. Henry

A. Abdul-Sultan

A.J. Walker

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology

DAVID HUMES david.humes@nottingham.ac.uk
Clinical Associate Professor



Abstract

Background:
This study aimed to identify burden and risk of VTE associated with cholecystectomy in England.

Methods:
An historical cohort study of cholecystectomy patients from 2001-2011 was undertaken using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data. Crude rates and adjusted hazard ratios (HRs) were calculated for risk of VTE following cholecystectomy using Cox regression.

Results:
24 677 patients were identified with a rate of VTE in the first year following cholecystectomy of 2.80 per 1000 person years (95% CI 2.18-3.59). Patients aged >/=70 vs aged 30 vs BMI less than 0 had 2.4-fold increase in risk (HR 2.42, 95% CI 1.40–4.18); open vs. laparoscopic operation had 3-fold increase in risk (HR 2.94, 95% CI 1.55–5.55). Compared to general population, VTE risk was the highest in the first 30 days post-operatively with 9.9-fold risk following emergency cholecystectomy and 4.5-fold risk after inpatient cholecystectomy (HR 9.90, 95% CI 4.42–22.21; HR 4.54, 95% CI 2.85–7.21).

Conclusions: Cholecystectomy is associated with a low absolute risk of VTE and we have identified high risk groups including the elderly, obese and those having open surgery.

Journal Article Type Article
Publication Date Apr 3, 2019
Journal Digestive Surgery
Print ISSN 0253-4886
Electronic ISSN 1421-9883
Publisher Karger Publishers
Peer Reviewed Peer Reviewed
Pages 1-7
APA6 Citation Henry, M., Abdul-Sultan, A., Walker, A., West, J., & Humes, D. (2019). Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study. Digestive Surgery, 1-7. https://doi.org/10.1159/000496435
DOI https://doi.org/10.1159/000496435
Keywords Surgery; Gastroenterology
Publisher URL https://www.karger.com/Article/Abstract/496435

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