Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study
Henry, M.L.; Abdul-Sultan, A.; Walker, A.J.; West, J.; Humes, D.J.
JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology
DAVID HUMES firstname.lastname@example.org
Clinical Associate Professor
This study aimed to identify burden and risk of VTE associated with cholecystectomy in England.
An historical cohort study of cholecystectomy patients from 2001-2011 was undertaken using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data. Crude rates and adjusted hazard ratios (HRs) were calculated for risk of VTE following cholecystectomy using Cox regression.
24 677 patients were identified with a rate of VTE in the first year following cholecystectomy of 2.80 per 1000 person years (95% CI 2.18-3.59). Patients aged >/=70 vs aged 30 vs BMI less than 0 had 2.4-fold increase in risk (HR 2.42, 95% CI 1.40–4.18); open vs. laparoscopic operation had 3-fold increase in risk (HR 2.94, 95% CI 1.55–5.55). Compared to general population, VTE risk was the highest in the first 30 days post-operatively with 9.9-fold risk following emergency cholecystectomy and 4.5-fold risk after inpatient cholecystectomy (HR 9.90, 95% CI 4.42–22.21; HR 4.54, 95% CI 2.85–7.21).
Conclusions: Cholecystectomy is associated with a low absolute risk of VTE and we have identified high risk groups including the elderly, obese and those having open surgery.
|Journal Article Type||Article|
|Publication Date||Apr 3, 2019|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Henry, M., Abdul-Sultan, A., Walker, A., West, J., & Humes, D. (2019). Duration and Magnitude of Postoperative Risk of Venous Thromboembolism after Cholecystectomy: A Population-Based Cohort Study. Digestive Surgery, 1-7. https://doi.org/10.1159/000496435|
Cholecystectomy VTE Paper Revised Word Doc.docx
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