Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway

Tildesley, Zoe; Chalmers, Jane; Harris, Rebecca; West , Joe; Guha , Indra Neil; Morling, Joanne Rebecca

Abstract

Objectives: There is a lack of understanding of health related quality of life (HRQoL) in chronic liver disease (CLD). With the rising prevalence of alcohol and obesity driven CLD, and the increasing ability to screen for fibrosis, it is important to understand the impact of the diagnostic process for patients.

Study design: Prospective cohort study

Methods: A cohort study conducted utilising the Nottingham Adult Liver Disease Stratification Pathway, UK. All patients referred as high risk for CLD (due to metabolic, alcohol or abnormal liver enzymes) completed the EQ-5D before diagnosis and at three and 12 months after. HRQoL was investigated by domain, CLD severity (transient elastography) and temporally.

Results: 493 patients participated with 300 (60.9%) completing at least one follow-up HRQoL assessment.

Pre-diagnosis the median (IQR) utility index was 0.75 (0.61-0.85) and visual analogue scale was 75/100 (60-90). The median utility index was significantly lower amongst those with advanced liver disease compared to those without at all time points (baseline 0.68 vs 0.77, three-months 0.65 vs 0.79, 12-months 0.69 vs 0.84, all p

Citation

Tildesley, Z., Chalmers, J., Harris, R., West, J., Guha, I. N., & Morling, J. R. (2020). Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway. Public Health In Practice, 1, Article 100033. https://doi.org/10.1016/j.puhip.2020.100033

• Journal Article Type: Article
• Acceptance Date: Jul 17, 2020
• Online Publication Date: Jul 25, 2020
• Publication Date: Nov 1, 2020
• Deposit Date: Aug 11, 2020
• Publicly Available Date: Aug 11, 2020
• Journal: Public Health in Practice
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 1
• Article Number: 100033
• DOI: https://doi.org/10.1016/j.puhip.2020.100033
• Keywords: Public Health, Environmental and Occupational Health; Health Policy
• Public URL: https://nottingham-repository.worktribe.com/output/4826184
• Publisher URL: https://www.sciencedirect.com/science/article/pii/S266653522030032X
• Related Public URLs: https://www.sciencedirect.com/journal/public-health-in-practice