Skip to main content

Research Repository

Advanced Search

Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway

Tildesley, Zoe; Chalmers, Jane; Harris, Rebecca; West , Joe; Guha , Indra Neil; Morling, Joanne Rebecca

Authors

Zoe Tildesley

Jane Chalmers

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology

NEIL GUHA neil.guha@nottingham.ac.uk
Professor of Hepatology

JOANNE MORLING JOANNE.MORLING@NOTTINGHAM.AC.UK
Clinician Scientist Fellowin Public Health



Abstract

Objectives: There is a lack of understanding of health related quality of life (HRQoL) in chronic liver disease (CLD). With the rising prevalence of alcohol and obesity driven CLD, and the increasing ability to screen for fibrosis, it is important to understand the impact of the diagnostic process for patients.

Study design: Prospective cohort study

Methods: A cohort study conducted utilising the Nottingham Adult Liver Disease Stratification Pathway, UK. All patients referred as high risk for CLD (due to metabolic, alcohol or abnormal liver enzymes) completed the EQ-5D before diagnosis and at three and 12 months after. HRQoL was investigated by domain, CLD severity (transient elastography) and temporally.

Results: 493 patients participated with 300 (60.9%) completing at least one follow-up HRQoL assessment.

Pre-diagnosis the median (IQR) utility index was 0.75 (0.61-0.85) and visual analogue scale was 75/100 (60-90). The median utility index was significantly lower amongst those with advanced liver disease compared to those without at all time points (baseline 0.68 vs 0.77, three-months 0.65 vs 0.79, 12-months 0.69 vs 0.84, all p

Citation

Tildesley, Z., Chalmers, J., Harris, R., West, J., Guha, I. N., & Morling, J. R. (2020). Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway. Public Health In Practice, 1, https://doi.org/10.1016/j.puhip.2020.100033

Journal Article Type Article
Acceptance Date Jul 17, 2020
Online Publication Date Jul 25, 2020
Publication Date Nov 1, 2020
Deposit Date Aug 11, 2020
Publicly Available Date Aug 11, 2020
Journal Public Health in Practice
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 1
Article Number 100033
DOI https://doi.org/10.1016/j.puhip.2020.100033
Public URL https://nottingham-repository.worktribe.com/output/4826184
Publisher URL https://www.sciencedirect.com/science/article/pii/S266653522030032X
Related Public URLs https://www.sciencedirect.com/journal/public-health-in-practice

Files

Health related quality of life in individuals at high risk of chronic liver disease: Impact of a community diagnostic pathway (817 Kb)
PDF

Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/


Appendices PUHiP (449 Kb)
PDF

Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/





You might also like



Downloadable Citations