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Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma

Bishton, Mark J; Crooks, Colin J; Card, Timothy R; West, Joe

Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma Thumbnail


Authors

Mark J Bishton

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology



Abstract

To address the lack of contemporary population-based epidemiological studies of hepatosplenic T-cell lymphoma (HSTCL), we undertook a population-based study of ICD-O-3-coded HSTCL in England. We used the National Cancer Registration Dataset and linked datasets on hospital admissions, Systemic Anti-Cancer Therapy, socio-demographics, comorbidities and death, identifying cases from 1 January 2013 to 31 December 2019 with survival data up to 5 January 2021. Crude and directly age-standardised incidence rates per million persons per year were calculated. Crude and adjusted incidence rate ratios compared incidence between groups using Poisson regression. A Cox proportional hazards model estimated mortality risks adjusted for age, sex, ethnicity, deprivation and allogenic stem cell transplant (allo-SCT; time varying). We identified 44 patients, mean age 42 years. Median survival was 11 months, and 1 and 5 year survivals were 48% (95% CI 29%–43%) and 22% (95% CI 12%–42%) respectively. The age-standardised incidence was 0.1 per million/year. Incidence was higher in areas with greater deprivation (0.15 per million/year), and more cases than expected were in non-White patients (39%). Non-Whites had a twofold increased risk of death (adjusted hazard ratio 2.21 [95% CI 1.03–4.78]) even after adjusting for deprivation, younger age and allo-SCT. In conclusion, ethnicity and socio-economic status affect both the incidence and survival of HSTCL.

Journal Article Type Article
Acceptance Date Feb 19, 2024
Online Publication Date Feb 29, 2024
Publication Date 2024-06
Deposit Date Feb 21, 2024
Publicly Available Date Mar 1, 2025
Journal British Journal of Haematology
Print ISSN 0007-1048
Electronic ISSN 1365-2141
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 204
Issue 6
Pages 2222-2226
DOI https://doi.org/10.1111/bjh.19371
Keywords Ethnicity; deprivation; Hepatosplenic lymphoma
Public URL https://nottingham-repository.worktribe.com/output/31610404
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/bjh.19371
Additional Information Received: 2023-12-04; Accepted: 2024-02-19; Published: 2024-02-29

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Br J Haematol - 2024 - Bishton - Ethnicity and socio‐economic status affects the incidence and survival of hepatosplenic (335 Kb)
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Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/

Copyright Statement
© 2024 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.





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