Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma

Bishton, Mark J; Crooks, Colin J; Card, Timothy R; West, Joe

Abstract

To address the lack of contemporary population-based epidemiological studies of hepatosplenic T-cell lymphoma (HSTCL), we undertook a population-based study of ICD-O-3-coded HSTCL in England. We used the National Cancer Registration Dataset and linked datasets on hospital admissions, Systemic Anti-Cancer Therapy, socio-demographics, comorbidities and death, identifying cases from 1 January 2013 to 31 December 2019 with survival data up to 5 January 2021. Crude and directly age-standardised incidence rates per million persons per year were calculated. Crude and adjusted incidence rate ratios compared incidence between groups using Poisson regression. A Cox proportional hazards model estimated mortality risks adjusted for age, sex, ethnicity, deprivation and allogenic stem cell transplant (allo-SCT; time varying). We identified 44 patients, mean age 42 years. Median survival was 11 months, and 1 and 5 year survivals were 48% (95% CI 29%–43%) and 22% (95% CI 12%–42%) respectively. The age-standardised incidence was 0.1 per million/year. Incidence was higher in areas with greater deprivation (0.15 per million/year), and more cases than expected were in non-White patients (39%). Non-Whites had a twofold increased risk of death (adjusted hazard ratio 2.21 [95% CI 1.03–4.78]) even after adjusting for deprivation, younger age and allo-SCT. In conclusion, ethnicity and socio-economic status affect both the incidence and survival of HSTCL.

Citation

Bishton, M. J., Crooks, C. J., Card, T. R., & West, J. (2024). Ethnicity and socio-economic status affects the incidence and survival of hepatosplenic T-cell lymphoma. British Journal of Haematology, 204(6), 2222-2226. https://doi.org/10.1111/bjh.19371

• Journal Article Type: Article
• Acceptance Date: Feb 19, 2024
• Online Publication Date: Feb 29, 2024
• Publication Date: 2024-06
• Deposit Date: Feb 21, 2024
• Publicly Available Date: Mar 1, 2025
• Journal: British Journal of Haematology
• Print ISSN: 0007-1048
• Electronic ISSN: 1365-2141
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 204
• Issue: 6
• Pages: 2222-2226
• DOI: https://doi.org/10.1111/bjh.19371
• Keywords: Ethnicity; deprivation; Hepatosplenic lymphoma
• Public URL: https://nottingham-repository.worktribe.com/output/31610404
• Publisher URL: https://onlinelibrary.wiley.com/doi/10.1111/bjh.19371
• Additional Information: Received: 2023-12-04; Accepted: 2024-02-19; Published: 2024-02-29