Harmony E. Otete
Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data
Otete, Harmony E.; Deleuran, T.; Fleming, Kate M.; Card, Timothy R.; Aithal, Guruprasad P.; Jepsen, P.; West, Joe
Authors
T. Deleuran
Kate M. Fleming
Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor
GURUPRASAD AITHAL Guru.Aithal@nottingham.ac.uk
Professor of Hepatology
P. Jepsen
JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology
Abstract
© 2018 European Association for the Study of the Liver Background & Aims: Cirrhosis, the prevalence of which is increasing, is a risk factor for osteoporosis and fractures. However, little is known of the actual risk of hip fractures in patients with alcoholic cirrhosis. Using linked primary and secondary care data from the English and Danish nationwide registries, we quantified the hip fracture risk in two national cohorts of patients with alcoholic cirrhosis. Methods: We followed 3,706 English and 17,779 Danish patients with a diagnosis of alcoholic cirrhosis, and we identified matched controls from the general populations. We estimated hazard ratios (HR) of hip fracture for patients vs. controls, adjusted for age, sex and comorbidity. Results: The five-year hip fracture risk was raised both in England (2.9% vs. 0.8% for controls) and Denmark (4.6% vs. 0.9% for controls). With confounder adjustment, patients with cirrhosis had fivefold (adjusted HR 5.5; 95% CI 4.3–6.9), and 8.5-fold (adjusted HR 8.5; 95% CI 7.8–9.3) increased rates of hip fracture, in England and Denmark, respectively. This association between alcoholic cirrhosis and risk of hip fracture showed significant interaction with age (p
Citation
Otete, H. E., Deleuran, T., Fleming, K. M., Card, T. R., Aithal, G. P., Jepsen, P., & West, J. (2018). Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data. Journal of Hepatology, 69(3), 697-704. https://doi.org/10.1016/j.jhep.2018.04.002
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 4, 2018 |
Online Publication Date | Apr 17, 2018 |
Publication Date | Sep 1, 2018 |
Deposit Date | Apr 6, 2018 |
Publicly Available Date | Mar 28, 2024 |
Journal | Journal of Hepatology |
Electronic ISSN | 1600-0641 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 69 |
Issue | 3 |
Pages | 697-704 |
DOI | https://doi.org/10.1016/j.jhep.2018.04.002 |
Keywords | Hip fracture, alcoholic liver disease, cirrhosis, mortality, epidemiology |
Public URL | https://nottingham-repository.worktribe.com/output/926245 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0168827818319780 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
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