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Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data

Otete, Harmony E.; Deleuran, T.; Fleming, Kate M.; Card, Timothy R.; Aithal, Guruprasad P.; Jepsen, P.; West, Joe

Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data Thumbnail


Authors

Harmony E. Otete

T. Deleuran

Kate M. Fleming

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor

P. Jepsen

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology



Abstract

© 2018 European Association for the Study of the Liver Background & Aims: Cirrhosis, the prevalence of which is increasing, is a risk factor for osteoporosis and fractures. However, little is known of the actual risk of hip fractures in patients with alcoholic cirrhosis. Using linked primary and secondary care data from the English and Danish nationwide registries, we quantified the hip fracture risk in two national cohorts of patients with alcoholic cirrhosis. Methods: We followed 3,706 English and 17,779 Danish patients with a diagnosis of alcoholic cirrhosis, and we identified matched controls from the general populations. We estimated hazard ratios (HR) of hip fracture for patients vs. controls, adjusted for age, sex and comorbidity. Results: The five-year hip fracture risk was raised both in England (2.9% vs. 0.8% for controls) and Denmark (4.6% vs. 0.9% for controls). With confounder adjustment, patients with cirrhosis had fivefold (adjusted HR 5.5; 95% CI 4.3–6.9), and 8.5-fold (adjusted HR 8.5; 95% CI 7.8–9.3) increased rates of hip fracture, in England and Denmark, respectively. This association between alcoholic cirrhosis and risk of hip fracture showed significant interaction with age (p

Citation

Otete, H. E., Deleuran, T., Fleming, K. M., Card, T. R., Aithal, G. P., Jepsen, P., & West, J. (2018). Hip fracture risk in patients with alcoholic cirrhosis: a population-based study using English and Danish data. Journal of Hepatology, 69(3), 697-704. https://doi.org/10.1016/j.jhep.2018.04.002

Journal Article Type Article
Acceptance Date Apr 4, 2018
Online Publication Date Apr 17, 2018
Publication Date Sep 1, 2018
Deposit Date Apr 6, 2018
Publicly Available Date Mar 28, 2024
Journal Journal of Hepatology
Electronic ISSN 1600-0641
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 69
Issue 3
Pages 697-704
DOI https://doi.org/10.1016/j.jhep.2018.04.002
Keywords Hip fracture, alcoholic liver disease, cirrhosis, mortality, epidemiology
Public URL https://nottingham-repository.worktribe.com/output/926245
Publisher URL https://www.sciencedirect.com/science/article/pii/S0168827818319780

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