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Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry

Davies, M.; West, J.; Williams, C.; Gardner, David S.

Authors

M. Davies

J. West

C. Williams

David S. Gardner



Abstract

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85-7.70] v MCPD, 4.30 [3.25-6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P

Journal Article Type Article
Journal Veterinary Record
Print ISSN 0042-4900
Electronic ISSN 0042-4900
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 180
Issue 18
APA6 Citation Davies, M., West, J., Williams, C., & Gardner, D. S. (in press). Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry. Veterinary Record, 180(18), doi:10.1136/vr.103953
DOI https://doi.org/10.1136/vr.103953
Keywords copper; medial coronoid process disease; minerals; zinc
Publisher URL http://veterinaryrecord.bmj.com/content/180/18/448
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Hair mineral status in dogs with MCPD. FINAL ACCEPTED 23-01-17.pdf (846 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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