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All Outputs (110)

A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink (2018)
Journal Article

Purpose: The CirCom score has been developed from Danish data as a specific measure of comorbidity for cirrhosis to predict all-cause mortality. We compared its performance with the Charlson Comorbidity Index (CCI) in an English cirrhosis population.... Read More about A validation study of the CirCom comorbidity score in an English cirrhosis population using the Clinical Practice Research Datalink.

Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly? (2017)
Journal Article

Objectives: Mortality due to liver disease (of which cirrhosis is the end‐stage) is increasing more than any other chronic condition in the UK. This study aims to demonstrate that (i) exclusive reliance on mortality rates may not reveal the true burd... Read More about Liver cirrhosis in England--an observational study: are we measuring its burden occurrence correctly?.

Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry (2017)
Journal Article

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs... Read More about Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry.

Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study (2017)
Journal Article

Background: Among patients with cirrhosis, only those determined to be at risk for hepatocellular carcinoma (HCC) should undergo surveillance. However, little is known about how different aetiologies of cirrhosis affect risk for HCC. Aim: To quantif... Read More about Risk of hepatocellular carcinoma among individuals with different aetiologies of cirrhosis: a population-based cohort study.

Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study (2016)
Journal Article

Objective: To develop and validate a risk prediction model for venous thromboembolism in the first six weeks after delivery (early postpartum). Design: Cohort study. Setting: Records from England based Clinical Practice Research Datalink (CPRD)... Read More about Development and validation of risk prediction model for venous thromboembolism in postpartum women: multinational cohort study.

The use of a bayesian hierarchy to develop and validate a co-morbidity score to predict mortality for linked primary and secondary care data from the NHS in England (2016)
Journal Article

Background: We have assessed whether the linkage between routine primary and secondary care records provided an opportunity to develop an improved population based co-morbidity score with the combined information on co-morbidities from both health ca... Read More about The use of a bayesian hierarchy to develop and validate a co-morbidity score to predict mortality for linked primary and secondary care data from the NHS in England.

Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England (2016)
Journal Article

Background: There is limited contemporary population based evidence on adverse birth outcomes and pregnancy related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variatio... Read More about Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England.

The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study (2016)
Journal Article

Background: Patients with coeliac disease are considered as individuals for whom pneumococcal vaccination is advocated. Aim: To quantify the risk of community-acquired pneumonia among patients with coeliac disease, assessing whether vaccination ag... Read More about The risk of community-acquired pneumonia among 9803 patients with coeliac disease compared to the general population: a cohort study.

Alcohol-attributable healthcare attendances up to 10 years prior to diagnosis of alcoholic cirrhosis: a population based case-control study (2015)
Journal Article

BACKGROUND & AIMS: Cirrhosis because of alcohol could be avoided if drinking behaviour could be altered earlier in the disease course. Our aim was to quantify the burden of morbidities in patients prior to alcoholic cirrhosis diagnosis, as this may... Read More about Alcohol-attributable healthcare attendances up to 10 years prior to diagnosis of alcoholic cirrhosis: a population based case-control study.

When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English healthcare data (2015)
Journal Article

Breast cancer patients are at increased risk of VTE, particularly in the peri-diagnosis period. However, no previous epidemiological studies have investigated the relative impact of breast cancer treatments in a time-dependent manner. We aimed to det... Read More about When are breast cancer patients at highest risk of venous thromboembolism? A cohort study using English healthcare data.

Defining venous thromboembolism and measuring its incidence using Swedish health registries: a nationwide pregnancy cohort study (2015)
Journal Article

Objective: To accurately define venous thromboembolism (VTE) in the routinely collected Swedish health registers and quantify its incidence in and around pregnancy. Study design: Cohort study using data from the Swedish Medical Birth Registry (MBR)... Read More about Defining venous thromboembolism and measuring its incidence using Swedish health registries: a nationwide pregnancy cohort study.

Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment (2015)
Journal Article

INTRODUCTION: Health economic models are increasingly important in funding decisions but most are based on data, which may therefore not represent the general population. We sought to establish the potential of real-world data available within the Cl... Read More about Calculating total health service utilisation and costs from routinely collected electronic health records using the example of patients with irritable bowel syndrome before and after their first gastroenterology appointment.

Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study (2015)
Journal Article

BACKGROUND: Irritable bowel syndrome (IBS), a chronic functional condition, considerably reduces quality of life (QoL) and referral to gastroenterology is common. Until now, however, the impact of seeing a gastroenterologist for IBS on patients’ QoL... Read More about Change in quality of life for patients with irritable bowel syndrome following referral to a gastroenterologist: a cohort study.

Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis (2015)
Journal Article

Aim: To estimate sex differences in health-care utilization among harmful/hazardous drinkers in the period before alcoholic cirrhosis diagnosis, and estimate sex differences in the extent to which alcohol use and brief alcohol interventions were docu... Read More about Sex and age differences in the early identification and treatment of alcohol use: a population-based study of patients with alcoholic cirrhosis.

Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study (2015)
Journal Article

Introduction Liver cirrhosis is increasing worldwide and associated with high mortality. Precise estimates of cause-specific mortality compared to the general population, by underlying aetiology, are lacking. Such information may demonstrate areas w... Read More about Causes of death in people with liver cirrhosis in England compared to the general population: a population-based cohort study.

Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis (2015)
Journal Article

INTRODUCTION: Quantifying excess cause-specific mortality among people with coeliac disease (CD) compared with the general population accounting for competing risks will allow accurate information to be given on risk of death from specific causes.... Read More about Causes of death in people with coeliac disease in England compared with the general population: a competing risk analysis.

A comparison of the recording of comorbidity in primary and secondary care by using the Charlson Index to predict short-term and long-term survival in a routine linked data cohort (2015)
Journal Article

OBJECTIVE: Hospital admission records provide snapshots of clinical histories for a subset of the population admitted to hospital. In contrast, primary care records provide continuous clinical histories for complete populations, but might lack detail... Read More about A comparison of the recording of comorbidity in primary and secondary care by using the Charlson Index to predict short-term and long-term survival in a routine linked data cohort.