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Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England

Abdul Sultan, Alyshah; West, Joe; Ban, Lu; Humes, David; Tata, Laila J.; Fleming, Kate M.; Nelson-Piercy, Catherine; Card, Timothy R.

Authors

Alyshah Abdul Sultan

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology

Lu Ban

DAVID HUMES david.humes@nottingham.ac.uk
Clinical Associate Professor

Kate M. Fleming

Catherine Nelson-Piercy

Dr TIM CARD tim.card@nottingham.ac.uk
Clinical Associate Professor



Abstract

Background: There is limited contemporary population based evidence on adverse birth outcomes and pregnancy related complications for women with inflammatory bowel disease (IBD). This study provides such estimates of these risks and assesses variation by IBD type and surgical interventions.

Methods: We calculated the proportion of pregnancies in women with and without IBD between 1997 and 2012 throughout England using linked primary (Clinical Practice Research Datalink-CPRD) and secondary care (Hospital Episode Statistics-HES) data. Risk of pregnancy related complications and adverse birth outcome in women with Crohn’s Disease-CD and Ulcerative Colitis-UC were compared to risks in women without IBD using odds ratios (OR).

Results: Of 364,363 singleton pregnancies resulting in live or stillbirths 1,969 (0.5%) were in women with IBD. Women with CD were more likely to have pre-term births (OR=1.42 95%CI;1.12-1.79), babies with low birth weights (OR=1.39;1.05-1.83) and postpartum haemorrhage (OR=1.27;1.04-1.55) whereas women with UC were only at increased risk of pre-term births with an absolute risk difference of

Citation

Abdul Sultan, A., West, J., Ban, L., Humes, D., Tata, L. J., Fleming, K. M., …Card, T. R. (2016). Adverse pregnancy outcomes among women with inflammatory bowel disease: a population based study from England. Inflammatory Bowel Diseases, 22(7), 1621-1630. https://doi.org/10.1097/MIB.0000000000000802

Journal Article Type Article
Acceptance Date Feb 29, 2016
Publication Date Jul 1, 2016
Deposit Date Aug 3, 2016
Publicly Available Date Mar 29, 2024
Journal Inflammatory Bowel Diseases
Print ISSN 1078-0998
Electronic ISSN 1536-4844
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 22
Issue 7
Pages 1621-1630
DOI https://doi.org/10.1097/MIB.0000000000000802
Keywords Inflammatory bowel disease, Adverse birth outcomes
Public URL https://nottingham-repository.worktribe.com/output/975778
Publisher URL http://journals.lww.com/ibdjournal/pages/articleviewer.aspx?year=2016&issue=07000&article=00011&type=abstract
Additional Information This is a non-final version of an article published in final form in Abdul Sultan, Alyshah; West, Joe; Ban, Lu; Humes, David; Tata, Laila J.; Fleming, Kate M.; Nelson-Piercy, Catherine; Card, Timothy (2016) Adverse pregnancy outcomes among women with inflammatory bowel disease: a population-based study from England . Inflammatory Bowel Diseases v. 22 (7). pp. 1621-1630.

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