All Outputs (44)

Synthesis of spirocyclic enones by rhodium-catalyzed dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes (2014)
Journal Article
Kujawa, S., Best, D., Burns, D. J., & Lam, H. W. (2014). Synthesis of spirocyclic enones by rhodium-catalyzed dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes. Chemistry - A European Journal, 20(28), https://doi.org/10.1002/chem.201403454

The dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes proceeds with high yields and regioselectivities under Rh(III) catalysis. These reactions are successful using Cu(OAc)2 or air as the stoichiometric oxidant, and provi... Read More about Synthesis of spirocyclic enones by rhodium-catalyzed dearomatizing oxidative annulation of 2-alkenylphenols with alkynes and enynes.

Enantioselective synthesis of allylboronates and allylic alcohols by copper-catalyzed 1,6-boration (2014)
Journal Article
Luo, Y., Roy, I. D., Madec, A. G., & Lam, H. W. (2014). Enantioselective synthesis of allylboronates and allylic alcohols by copper-catalyzed 1,6-boration. Angewandte Chemie International Edition, 53(16), https://doi.org/10.1002/anie.201310380

Chiral secondary allylboronates are obtained in high enantioselectivities by the copper-catalyzed 1,6-boration of electron-deficient dienes with B2(pin)2. The reactions proceed efficiently using catalyst loadings as low as 0.0049 mol%. The allylboron... Read More about Enantioselective synthesis of allylboronates and allylic alcohols by copper-catalyzed 1,6-boration.

A second-generation ligand for the enantioselective rhodium-catalyzed addition of arylboronic acids to alkenylazaarenes (2014)
Journal Article
Roy, I. D., Burns, A. R., Pattison, G., Michel, B., Parker, A. J., & Lam, H. W. (2014). A second-generation ligand for the enantioselective rhodium-catalyzed addition of arylboronic acids to alkenylazaarenes. Chemical Communications, 50(22), https://doi.org/10.1039/C4CC00340C

A 2,4,6-trialkylanilide-containing chiral diene has been identified as a superior ligand for the enantioselective rhodiumcatalyzed arylation of alkenylazaarenes with arylboronic acids.

C=N-containing azaarenes as activating groups in enantioselective catalysis (2013)
Journal Article
Best, D., & Lam, H. W. (2013). C=N-containing azaarenes as activating groups in enantioselective catalysis. Journal of Organic Chemistry, 79(3), https://doi.org/10.1021/jo402414k

Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chi-ral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use... Read More about C=N-containing azaarenes as activating groups in enantioselective catalysis.