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C=N-containing azaarenes as activating groups in enantioselective catalysis

Best, Daniel; Lam, Hon Wai

Authors

Daniel Best

Hon Wai Lam

Abstract

Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chi-ral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepare chiral azaarene-containing compounds: exploitation of the C=N bond embedded within certain azaarenes to activate adjacent functionality in catalytic asym-metric reactions. Work in this area has resulted in the development of several different types of catalytic enantioselec-tive processes, including reductions, nucleophilic additions, and reductive couplings. It is hoped that this Perspective will encourage more researchers to work in this promising area.

Journal Article Type Article
Publication Date Dec 16, 2013
Journal Journal of Organic Chemistry
Print ISSN 0022-3263
Electronic ISSN 0022-3263
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 79
Issue 3
Institution Citation Best, D., & Lam, H. W. (2013). C=N-containing azaarenes as activating groups in enantioselective catalysis. Journal of Organic Chemistry, 79(3), doi:10.1021/jo402414k
DOI https://doi.org/10.1021/jo402414k
Publisher URL http://pubs.acs.org/doi/abs/10.1021/jo402414k
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
Additional Information This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/pag...lesonrequest/index.html

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0




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