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C=N-containing azaarenes as activating groups in enantioselective catalysis

Best, Daniel; Lam, Hon Wai

Authors

Daniel Best

HON LAM Hon.Lam@nottingham.ac.uk
Professor of Sustainable Chemistry



Abstract

Nitrogen-containing aromatic heterocycles (azaarenes) are of widespread chemical significance, and chi-ral compounds containing azaarenes feature prominently in pharmaceuticals, agrochemicals, and natural products. This Perspective highlights the use of a relatively underdeveloped strategy to prepare chiral azaarene-containing compounds: exploitation of the C=N bond embedded within certain azaarenes to activate adjacent functionality in catalytic asym-metric reactions. Work in this area has resulted in the development of several different types of catalytic enantioselec-tive processes, including reductions, nucleophilic additions, and reductive couplings. It is hoped that this Perspective will encourage more researchers to work in this promising area.

Citation

Best, D., & Lam, H. W. (2013). C=N-containing azaarenes as activating groups in enantioselective catalysis. Journal of Organic Chemistry, 79(3), doi:10.1021/jo402414k

Journal Article Type Article
Publication Date Dec 16, 2013
Deposit Date Feb 12, 2016
Publicly Available Date Feb 12, 2016
Journal Journal of Organic Chemistry
Print ISSN 0022-3263
Electronic ISSN 0022-3263
Publisher American Chemical Society
Peer Reviewed Peer Reviewed
Volume 79
Issue 3
DOI https://doi.org/10.1021/jo402414k
Public URL http://eprints.nottingham.ac.uk/id/eprint/31655
Publisher URL http://pubs.acs.org/doi/abs/10.1021/jo402414k
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
Additional Information This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Journal of Organic Chemistry, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/pag...lesonrequest/index.html

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HWL Dan JOC Perspective (Revised).pdf (2.6 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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