Yunfei Luo
Enantioselective synthesis of allylboronates and allylic alcohols by copper-catalyzed 1,6-boration
Luo, Yunfei; Roy, Iain D.; Madec, Ama�l G.E.; Lam, Hon Wai
Authors
Abstract
Chiral secondary allylboronates are obtained in high enantioselectivities by the copper-catalyzed 1,6-boration of electron-deficient dienes with B2(pin)2. The reactions proceed efficiently using catalyst loadings as low as 0.0049 mol%. The allylboronates may be oxidized to the allylic alcohols, and can be used in stereoselective aldehyde allylborations. This process was applied to a concise synthesis of atorvastatin.
Citation
Luo, Y., Roy, I. D., Madec, A. G., & Lam, H. W. (2014). Enantioselective synthesis of allylboronates and allylic alcohols by copper-catalyzed 1,6-boration. Angewandte Chemie International Edition, 53(16), https://doi.org/10.1002/anie.201310380
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 5, 2014 |
Online Publication Date | Mar 12, 2014 |
Publication Date | Apr 14, 2014 |
Deposit Date | Feb 12, 2016 |
Publicly Available Date | Feb 12, 2016 |
Journal | Angewandte Chemie International Edition |
Print ISSN | 1433-7851 |
Electronic ISSN | 1521-3773 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 53 |
Issue | 16 |
DOI | https://doi.org/10.1002/anie.201310380 |
Public URL | https://nottingham-repository.worktribe.com/output/725135 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1002/anie.201310380/abstract |
Additional Information | This is the peer reviewed version of the following article: Luo, Y., Roy, I. D., Madec, A. G. E. and Lam, H. W. (2014), Enantioselective Synthesis of Allylboronates and Allylic Alcohols by Copper-Catalyzed 1,6-Boration. Angew. Chem. Int. Ed., 53: 4186–4190. doi:10.1002/anie.201310380, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/anie.201310380/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Contract Date | Feb 12, 2016 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
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