All Outputs (60)

Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning (2019)
Journal Article

Rationale Dopamine D1 receptor (D1R) signalling is involved in contextual fear conditioning. The D1R antagonist SCH23390 impairs the acquisition of contextual fear when administered systemically or infused locally into the dorsal hippocampus or ba... Read More about Dopamine D1-like receptors in the dorsomedial prefrontal cortex regulate contextual fear conditioning.

The neuropharmacology of what, where, when: how dopamine modulates recognition memory for objects and their contexts (2018)
Book Chapter

Recognition of objects and their contexts is demonstrated based on the intrinsic features of objects (‘what’), as well as for spatial (‘where’) or temporal presentation (‘when’) cues. A network of structures identified in lesion studies forms a neura... Read More about The neuropharmacology of what, where, when: how dopamine modulates recognition memory for objects and their contexts.

Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure (2018)
Journal Article

Trace conditioning is impaired by lesions to dorsal hippocampus, as well as by treatment with the muscarinic acetylcholine antagonist scopolamine. However, the role of muscarinic receptors within hippocampus has received little attention. The present... Read More about Infusions of scopolamine in dorsal hippocampus reduce anticipatory responding in an appetitive trace conditioning procedure.

Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay (2017)
Journal Article

Previous in vivo electrophysiological studies suggest that the anterior cingulate cortex (ACgx) is an important substrate of novel object recognition (NOR) memory. However, intervention studies are needed to confirm this conclusion and permanent lesi... Read More about Role of the anterior cingulate cortex in the retrieval of novel object recognition memory after a long delay.

Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex (2017)
Journal Article

The muscarinic acetylcholine (ACh) receptor is an important modulator of medial prefrontal cortex (mPFC) functions, such as the working memory required to bridge a trace interval in associative leaning. Aversive and appetitive trace conditioning proc... Read More about Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex.

Overshadowing depends on cue and reinforcement sensitivity but not schizotypy (2016)
Journal Article

There is evidence for impaired selective learning mechanisms in individuals high in schizotypy. Overshadowing provides a direct test of selective learning based on cue salience and has previously been reported to be impaired in relation to schizotypy... Read More about Overshadowing depends on cue and reinforcement sensitivity but not schizotypy.

Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare (2016)
Journal Article

Improving laboratory animal science and welfare requires both new scientific research and insights from enquiry in the humanities and social sciences. Whilst scientific research provides evidence to replace, reduce and refine procedures involving lab... Read More about Developing a Collaborative Agenda for Humanities and Social Scientific Research on Laboratory Animal Science and Welfare.

The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials (2016)
Journal Article

In an appetitively motivated procedure, we have previously reported that systemic treatment with the dopamine (DA) D1 receptor agonist SKF81297 (0.4 and 0.8 mg/kg) depressed acquisition at a 2s inter-stimulus-interval (ISI), suitable to detect trace... Read More about The dopamine D1 receptor agonist SKF81297 has dose-related effects on locomotor activity but is without effect in a CER trace conditioning procedure conducted with two versus four trials.

Potentiation rather than distraction in a trace fear conditioning procedure (2016)
Journal Article

Trace conditioning procedures are defined by the introduction of a trace interval between conditioned stimulus (CS, e.g. noise or light) offset and unconditioned stimulus (US, e.g. footshock). The introduction of an additional stimulus as a distracto... Read More about Potentiation rather than distraction in a trace fear conditioning procedure.

Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes (2015)
Journal Article

Conditioned inhibition occurs when a stimulus inhibits the responses that would normally occur to a conditioned stimulus that previously predicted an outcome of interest (the unconditioned stimulus, which elicits responding unconditionally). The pres... Read More about Conditioned inhibition of emotional responses: retardation and summation with cues for IAPS outcomes.

Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure (2015)
Journal Article

The anterior cingulate cortex (AC) component of the medial prefrontal cortex (mPFC) has been implicated in attention and working memory as measured by trace conditioning. Since dopamine (DA) is a key modulator of mPFC function, the present study eval... Read More about Effects of dopamine D1 modulation of the anterior cingulate cortex in a fear conditioning procedure.

Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex. (2015)
Journal Article

© 2015 The Authors. Previous studies have shown that dopamine D1 receptor antagonists impair novel object recognition memory but the effects of dopamine D1 receptor stimulation remain to be determined. This study investigated the effects of the selec... Read More about Dopamine D1 receptor stimulation modulates the formation and retrieval of novel object recognition memory: role of the prelimbic cortex..

Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with ??-tetrahydrocannabinol (THC) (2015)
Journal Article

Rats’ performance on a progressive-ratio schedule maintained by sucrose (0.6 M, 50 μl) and corn oil (100%, 25 μl) reinforcers was assessed using a model derived from Killeen’s (1994) theory of scheduled-controlled behaviour, ‘Mathematical Principles... Read More about Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with ??-tetrahydrocannabinol (THC).

Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex (2015)
Journal Article

Rationale: Trace conditioning may provide a behavioural model suitable to examine the maintenance of ‘on line’ information and its underlying neural substrates. Objectives: Experiment la was run to establish trace conditioning in a shortened proced... Read More about Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.

Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population (2015)
Journal Article

Attention-Deficit/Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, they show comorbidity and inhibitory control deficits have been proposed to underlie both. The role of reinforcement sensit... Read More about Gray’s revised Reinforcement Sensitivity Theory in relation to Attention-Deficit/Hyperactivity and Tourette-like behaviors in the general population.

Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues (2015)
Journal Article

Treatment with selective serotonin reuptake inhibitors (SSRIs) can reduce contextual conditioning. Since contexts present a variety of potentially competing cues, impaired overshadowing may provide an account of such effects. The present study theref... Read More about Intraperitoneal sertraline and fluvoxamine increase contextual fear conditioning but are without effect on overshadowing between cues.

Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats (2014)
Journal Article

The evidence for cognitively enhancing effects of 5-hydroxytryptamine6 (5-HT6) receptor antagonists such as Ro 04-6790 is inconsistent and seems to depend on the behavioural test variant in use. Trace conditioning holds promise as a behavioral assay... Read More about Ro 04-6790-induced cognitive enhancement: No effect in trace conditioning and novel object recognition procedures in adult male Wistar rats.

From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations (2014)
Journal Article

Distinctions along the dorsal-ventral axis of medial prefrontal cortex (mPFC), between anterior cingulate (AC), prelimbic (PL) and infralimbic (IL) sub-regions, have been proposed on a variety of neuroanatomical and neurophysiological grounds. Conven... Read More about From attention to memory along the dorsal-ventral axis of the medial prefrontal cortex: some methodological considerations.

Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition (2014)
Journal Article

Attention-Deficit Hyperactivity Disorder (ADHD) and Tourette Syndrome (TS) present as distinct conditions clinically; however, comorbidity and inhibitory control deficits have been proposed for both. Whilst such deficits have been studied widely with... Read More about Tourette-like behaviors in the normal population are associated with hyperactive/impulsive ADHD-like behaviors but do not relate to deficits in conditioned inhibition or response inhibition.

Do personality traits predict individual differences in excitatory and inhibitory learning? (2013)
Journal Article

Conditioned inhibition (CI) is demonstrated in classical conditioning when a stimulus is used to signal the omission of an otherwise expected outcome. This basic learning ability is involved in a wide range of normal behavior – and thus its disruptio... Read More about Do personality traits predict individual differences in excitatory and inhibitory learning?.