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Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex

Pezze, Marie A.; Marshall, H.J.; Cassaday, H.J.

Authors

Marie A. Pezze

H.J. Marshall

HELEN CASSADAY HELEN.CASSADAY@NOTTINGHAM.AC.UK
Professor of Behavioural Neuroscience



Abstract

Rationale: Trace conditioning may provide a behavioural model suitable to examine the maintenance of ‘on line’ information and its underlying neural substrates.
Objectives: Experiment la was run to establish trace conditioning in a shortened procedure which would be suitable to test the effects of dopamine (DA) D1 receptor agents administered by microinjection directly into the brain. Experiment lb examined the effects of the DA D1 agonist SKF81297 and the DA D1 antagonist SCH23390 following systemic administration in pre-trained animals. Experiment 2 went on to test the effects of systemically administered SKF81297 on the acquisition of trace conditioning. In experiment 3, SKF81297 was administered directly in prelimbic (PL) and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC) to compare the role of different mPFC sub-regions.
Results: Whilst treatment with SCH23390 impaired motor responding and/or motivation, SKF81297 had relatively little effect in the pre-trained animals tested in experiment 1b. However, systemic SKF81297 depressed the acquisition function at the 2-s trace interval in experiment 2. Similarly, in experiment 3, SKF81297 (0.1 μg in 1.0 μl) microinjected into either PL or IL mPFC impaired appetitive conditioning at the 2-s trace interval.
Conclusions: Impaired trace conditioning under SKF81297 is likely to be mediated in part (but not exclusively) within the IL and PL mPFC sub-regions. The finding that trace conditioning was impaired rather than enhanced under SKF81297 provides further evidence for the inverse U-function which has been suggested to be characteristic of mPFC DA function.

Journal Article Type Article
Journal Psychopharmacology
Print ISSN 0033-3158
Electronic ISSN 1432-2072
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 232
Issue 15
APA6 Citation Pezze, M. A., Marshall, H., & Cassaday, H. (in press). Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex. Psychopharmacology, 232(15), https://doi.org/10.1007/s00213-015-3903-4
DOI https://doi.org/10.1007/s00213-015-3903-4
Publisher URL http://link.springer.com/article/10.1007%2Fs00213-015-3903-4
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s00213-015-3903-4.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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