Marie A. Pezze
Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex
Pezze, Marie A.; Marshall, Hayley J.; Cassaday, Helen J.
Hayley J. Marshall
Helen J. Cassaday
The muscarinic acetylcholine (ACh) receptor is an important modulator of medial prefrontal cortex (mPFC) functions, such as the working memory required to bridge a trace interval in associative leaning. Aversive and appetitive trace conditioning procedures were used to examine the effects of scopolamine (0.1 and 0.5 mg/kg i.p.) in male rats. Follow-up experiments tested the effects of microinfusion of 0.15 μg scopolamine (0.075 μg in 0.5 μL/side) in infralimbic (IL) versus prelimbic (PL) regions of rat mPFC, in appetitive trace and locomotor activity (LMA) procedures. Systemic scopolamine was without effect in an aversive trace conditioning procedure but impaired appetitive conditioning at a 2 s trace interval. This effect was demonstrated as reduced responding during presentations of the conditioned stimulus (CS) as well as during the inter-stimulus-interval (ISI). There was no such effect on responding during food (unconditioned stimulus, US) responding or in the inter-trial-interval (ITI). In contrast, systemic scopolamine dose-relatedly increased LMA. Trace conditioning was similarly impaired at the 2 s trace (shown as reduced responding to the CS and during the ISI, but not during US presentations or in the ITI) after infusion in mPFC, whilst LMA was increased (after infusion in IL only). Thus, results point to the importance of cholinergic modulation in mPFC for trace conditioning and show that the observed effects cannot be attributed to reduced activity.
|Journal Article Type||Article|
|Publication Date||Jun 28, 2017|
|Journal||Journal of Neuroscience|
|Publisher||Society for Neuroscience|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Pezze, M. A., Marshall, H. J., & Cassaday, H. J. (2017). Scopolamine impairs appetitive but not aversive trace conditioning: role of the medial prefrontal cortex. Journal of Neuroscience, 37(26), https://doi.org/10.1523/JNEUROSCI.3308-16.2017|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Pezze et al 2017a FINAL.pdf
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0